Connective Tissues of the Periodontium: A Summary of Current Work

Narayanan, A. Sampath; C., Page Roy

doi:10.1016/s0174-173x(83)80047-8

Cited by 160 publications

(98 citation statements)

References 114 publications

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“…The bulk of gingival and other periodontal connective tissues consists of collagen fibrils, but a non-collagenous matrix is also present, including proteoglycans (PG), glycoproteins (GP), glycosaminoglycans (GAG) and small amounts of elastin [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Although extensive studies assessing the rate of collagen and protein turnover in periodontal tissues have been performed [6][7][8][9][10], relatively little is known about the non-collagenous matrix of the periodontium [3]. The turnover rate of collagens and non-collagenous proteins in the periodontium has been shown to be high [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…These changes are generally considered to be a consequence, not a cause, of the aging process [11]. Age is considered to be one of the factors affecting the synthesis of collagenr [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] and protein [11] in connective tissues. A marked reduction in protein and collagen production with increasing donor age has been shown in cultures established from normal human gingiva [11].…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyproline and Total Protein Levels in Gingiva and Gingival Crevicular Fluid in Periodontally Healthy Human Subjects.

Akalın

Şengün

Renda

et al. 1992

The Journal of Nihon University School of Dentistry

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Age is known to be one of the factors which affect the rate of collagen and protein turnover in the connective tissues of the periodontium. The aim of the present study was to determine the levels of hydroxyproline (Hyp) and total protein in both the gingiva and gingival crevicular fluid (GCF) of periodontally healthy human subjects of two different age groups. The subjects of the young group were selected from among patients scheduled for extraction of upper and lower first or second premolars for orthodontic reasons. The second (older) group included individuals whose teeth were to be extracted for endodontic reasons. GCF was obtained before gingival sampling. The tissues surrounding the sockets were harvested immediately after extraction of the indicated teeth. All samples were analyzed biochemically. No significant difference was found in gingival and GCF levels of Hyp (which is unique to collagen) between the groups. Total protein levels in gingiva were significantly higher in the young group than in the older group. GCF total protein levels showed no significant difference between the groups. The higher gingival protein levels in the younger group seem to conform to previous findings.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydroxyproline and Total Protein Levels in Gingiva and Gingival Crevicular Fluid in Periodontally Healthy Human Subjects.

Akalın

Şengün

Renda

et al. 1992

The Journal of Nihon University School of Dentistry

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show abstract

“…In the connective tissue, one of the major components of ECM is interstitial collagen. 16 These collagen fibers are functionally arranged to surround the teeth and thereby contribute to their support. In addition, the collagen provides mechanical properties and the scaffolding to the gingiva.…”

Section: Discussionmentioning

confidence: 99%

Occlusal Hypofunction Induces Atrophic Changes in Rat Gingiva

Ishida

Kanno

Soma

2008

The Angle Orthodontist

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Objective: To clarify the influence of occlusal hypofunction on the integrity of gingival tissue and gingival extracellular matrix biosynthesis. Materials and Methods: Thirteen-week-old male Wistar rats were divided into two groups. To eliminate occlusal forces, all the right maxillary molars were extracted in the hypofunctional group. The control group was anesthetized but not subjected to surgery. The rats were killed at 2 and 4 weeks after the procedure, and the lower right second molars were prepared for histological analysis. To investigate the effect of occlusal hypofunction on collagen biosynthesis, the expression of connective tissue growth factor (CTGF) and lysyl oxidase (LOX) was determined by immunohistochemistry as well as histological examination by hematoxylin and eosin staining. Results: Disorientation of the collagen fibers, proliferation of the connective tissue fibroblasts, and enlargement of epithelial intercellular gaps were observed in gingival tissue of rat molars with experimental occlusal hypofunction. Immunohistochemically, the expression of CTGF and LOX was increased significantly (P Ͻ .05) in the hypofunctional group. Conclusion: These results suggest that occlusal hypofunction can affect the structural integrity and the expression of CTGF and LOX in gingival tissue.

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“…Type I collagen composes 90 % of the organic matrix of bone and is the most abundant collagen in osseous tissue (Narayanan & Page 1983). Studies assessing the role of ICTP levels in GCF or peri-implant crevicular fluid as a diagnostic marker of periodontal disease activity have reported promising results so far (Oringer et al 1998(Oringer et al , 2002.…”

Section: Introductionmentioning

confidence: 99%

Effects of Tobacco Smoking on Chronic Periodontitis and Periodontal Treatment

Buduneli¹

2012

Pathogenesis and Treatment of Periodontitis

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Connective Tissues of the Periodontium: A Summary of Current Work

Cited by 160 publications

References 114 publications

Hydroxyproline and Total Protein Levels in Gingiva and Gingival Crevicular Fluid in Periodontally Healthy Human Subjects.

Hydroxyproline and Total Protein Levels in Gingiva and Gingival Crevicular Fluid in Periodontally Healthy Human Subjects.

Occlusal Hypofunction Induces Atrophic Changes in Rat Gingiva

Effects of Tobacco Smoking on Chronic Periodontitis and Periodontal Treatment

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