Connective Tissue XIII. Effect of Estradiol Benzoate upon Collagen Synthesis by Sponge Biopsy Connective Tissue.

Kao, Kung-Ying Tang; Hitt, William E.; McGavack, Thomas H.

doi:10.3181/00379727-119-30182

Cited by 14 publications

(7 citation statements)

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“…When both hormones are present, as in pregnancy, uterine smooth muscle cell and fibrous protein components increase absolutely severalfold (27). Estrogen also stimulates collagen synthesis by skin fibroblasts (15) and by cells in granulomas (16), but because catabolism is even more greatly accelerated the net amount of collagen in these tissues actually decreases compared to controls (15,16). In turnover studies with labeled proline of collagen from aortas, granulomas, and skin from guinea pigs, estrogen treatment increased the specific activity of soluble collagen fractions, suggesting that maturation to more highly cross-linked, stable insoluble collagen was interfered with (16).…”

Section: Discussionmentioning

confidence: 98%

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Effects of Estrogen and Progestogen Treatment on the Response of the Aorta of Male Rats to Hypertension: MORPHOLOGICAL AND CHEMICAL STUDIES

Wolinsky

1972

Circulation Research

108

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The effects of estrogen and progestogen treatment on the response of the thoracic aortic wall of male rats to hypertension were studied. Hypertension levels induced by cupping the renal artery were similar in untreated (H), estrogen-treated (E), and progestogen-treated (P) hypertensive groups. Hypertension of 8 weeks' duration caused increased wall thickness, increased calculated tangential tension, and increased medial area in groups H and P compared to normotensive controls (C), but wall thickness and medial area in groups E and C were similar despite the striking elevation in calculated tension and wall stress in group E. Chemical studies also showed that the absolute amounts of aortic collagen and elastin in groups H and P were similarly increased over group C values, but absolute amounts of both these fibrous proteins in vessels from group E were no different from those of group C. Noncollagenous alkali-soluble proteins in these vessels were present in absolute and relative amounts corresponding to the following rank: P > H > E > C.Thus, it appears that estrogen-treatment has a distinctly inhibitory effect and progestogen-treatment a slightly stimulatory effect on the aortic wall response to hypertension. Since hypertension-induced morphological and chemical changes have many similarities to features of arteriosclerotic plaque growth, recognition of these differences in hormonal effects on the response of the vessel wall to hypertension may have implications beyond their physiological role as sex hormones.KEY WORDS female sex hormones vessel wall tension elastin collagen blood vessels arteriosclerosis vascular disease renal hypertension • Two prominent features of the developing arteriosclerotic plaque are proliferation of smooth muscle cells and accumulation of extracellular fibrous proteins (1, 2). The initiating causes of these changes have been speculated on at length but remain unproved. Hypertension, both spontaneous and experiFrom the

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Section: Discussionmentioning

confidence: 98%

“…It is clear that the female sex hormones, particularly estrogen, exert profound influence on the morphology and metabolism of uterine smooth muscle cells (13,14) and skin fibroblasts (15,16). However, detailed information of this type is not available for the smooth muscle cells of the blood vessel wall.…”

mentioning

confidence: 98%

Effects of Estrogen and Progestogen Treatment on the Response of the Aorta of Male Rats to Hypertension: MORPHOLOGICAL AND CHEMICAL STUDIES

Wolinsky

1972

Circulation Research

108

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“…Estrogens administered to gonadectomized female rats (1,2) and guinea pigs (3) markedlv reduce the net amount of collagen in the aortic wall and skin. Labeled precursor studies of vascular collagen in females suggest that the mechanism responsible is a combination of accelerated turnover of a relatively small pool of soluble precursors of collagen and interference with progression of these precursors into the insoluble highly cross-linked form of collagen (1.…”

Section: Introductionmentioning

confidence: 99%

Effects of Androgen Treatment on the Male Rat Aorta

Wolinsky¹

1972

J. Clin. Invest.

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A B S T R A C T Androgen was given to male rats to determine if it exerted effects on the aortic wvall distinct from those of estrogen deficit. Although a general anabolic effect was avoided, significant vascular effects were observed. The amounts of mural fibrous proteins, elastin and collagen, were significantly increased in treated animals; noncollagenous, alkali-soluble protein, thought to reflect the cellular component, was unchanged with treatment. These effects were not detectable on microscopic examination and measurement of the vessel wall despite attempts to duplicate closely in vivo wall dimensions before study. These findings of distinct and marked effects of androgen on vascular metabolism extend the growing evidence for an important role of sex hormones in vessel wall structure and function. INTRODUCTIONRecent studies have shown that female sex hormones exert profound effects on vessel wall morphology and metabolism. Estrogens administered to gonadectomized female rats (1, 2) and guinea pigs (3) markedlv reduce the net amount of collagen in the aortic wall and skin. Labeled precursor studies of vascular collagen in females suggest that the mechanism responsible is a combination of accelerated turnover of a relatively small pool of soluble precursors of collagen and interference

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“…This finding is surpris ing with regard to skin aging, where interactions be tween estrogen deficiency and dermal and epidermal atrophy have been well described [28] as well the benefi cial effects of estrogen substitution on restoring dermal thickness have been reported [12,13]. Moreover, estro gens display various effects on other functions of skin, which are involved in skin aging [5][6][7], Collagen synthe sis and water retention properties [9. 10] and vasculari zation depend on estrogen stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, estrogens stimulate synthesis, maturation and turnover of collagen [4][5][6][7], increase the synthesis of hyaluronic acid [8] and promote water retention in sex ual skin of primates [9], Lastly, estrogens increase the vascularization of skin [10], In contrast, few and partly contradictory data exist on gestagenic influences on skin. Although in some cases the effects are similar to andro genic effects -e.g.…”

Section: Introductionmentioning

confidence: 99%

Hormone Receptors in Pubic Skin of Premenopausal and Postmenopausal Females

Schmidt

Lindmaier

Spona

1990

Gynecol Obstet Invest

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Various functions of the skin are hormone-dependent. Recently hormonal involvement in aging processes of the skin has attracted increasing interest. The rapid onset of aging of the skin from the climacterium on seems to be correlated with the decrease of estrogens. In order to evaluate hormonal stimulability of the skin a study of hormone receptors was performed in pre- and postclimacteric women. Pubic skin of a total of 106 females was obtained during gynecologic operations for determination of estrogen receptors (ER), androgen receptors (AR) and gestagen receptors (PgR) by saturation analysis. In the preclimacteric group consisting of 62 females with a mean age of 39.6 ± (SD) 6.5 years the operations were performed in the luteal phase of the menstrual cycle. The results were compared with those of 44 postmenopausal females with a mean age of 63.2 ± 9.4 years. AR concentrations were significantly lower in the skin of postmenopausal women. 47.4% positive findings with a mean receptor level of 15.3 ± 33.3 fmol/mg protein were to be found against 85.2% positive AR with a mean level of 31.4 ± 20.3 fmol/mg protein in the ovulatory cycling females. These findings were of high significance. In addition, diminished PgR in the postmenopausal group were noted for incidence and mean receptor levels. PgR were positive in 18.4% with a mean levelof34.2 ± 72.8 fmol/mg protein versus 36.3% with a mean receptor level of 34.2 ± 72.8 in the ovulatory group. In contrast, no significant differences between ER of premenopausal and postmenopausal skin became evident. Results of hormone receptor determinations in the premenopausal and postmenopausal group with regard to the aging process are interpreted.

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Connective Tissue XIII. Effect of Estradiol Benzoate upon Collagen Synthesis by Sponge Biopsy Connective Tissue.

Cited by 14 publications

References 0 publications

Effects of Estrogen and Progestogen Treatment on the Response of the Aorta of Male Rats to Hypertension: MORPHOLOGICAL AND CHEMICAL STUDIES

Effects of Estrogen and Progestogen Treatment on the Response of the Aorta of Male Rats to Hypertension: MORPHOLOGICAL AND CHEMICAL STUDIES

Effects of Androgen Treatment on the Male Rat Aorta

Hormone Receptors in Pubic Skin of Premenopausal and Postmenopausal Females

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