Connective Tissue Growth Factor Transgenic Mouse Develops Cardiac Hypertrophy, Lean Body Mass and Alopecia

Nuglozeh, Edem

doi:10.7860/jcdr/2017/28158.10284

JCDR

2017

DOI: 10.7860/jcdr/2017/28158.10284

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Connective Tissue Growth Factor Transgenic Mouse Develops Cardiac Hypertrophy, Lean Body Mass and Alopecia

Edem Nuglozeh

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2023

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Cited by 1 publication

References 33 publications

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The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

Albalawi

Hafez²,

El‐Hawary

et al. 2023

Sci Rep

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This study evaluated the topical effect of Lepidium sativum lyophilized seed extract (LSLE) towards Sustanon-induced alopecia in male adult Wistar albino rats in vivo, compared to minoxidil topical reference standard drug (MRD). LC–MS/MS together with molecular networking was used to profile the metabolites of LSLE. LSLE treated group revealed significant changes in alopecia related biomarkers, perturbation of androgenic markers; decline in testosterone level and elevation in 5α-reductase (5-AR); decline in the cholesterol level. On the other hand, LSLE treated group showed improvement in vascular markers; CTGF, FGF and VEGF. Groups treated topically with minoxidil and LSLE showed significant improvement in hair length. LC–MS/MS profile of LSLE tentatively identified 17 constituents: mainly glucosinolates, flavonoid glycosides, alkaloids and phenolic acids. The results point to the potential role of LSLE in the treatment of alopecia through decreasing 5(alpha)-dihydrotestosterone levels. Molecular docking was attempted to evaluate the probable binding mode of identified compounds to androgen receptor (PDB code: 4K7A).

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The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

Albalawi

Hafez²,

El‐Hawary

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

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Connective Tissue Growth Factor Transgenic Mouse Develops Cardiac Hypertrophy, Lean Body Mass and Alopecia

Cited by 1 publication

References 33 publications

The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

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