Connective Tissue Disease-Associated Interstitial Lung Disease and Outcomes After Hospitalization: A Cohort Study

Ratwani, Ankush; Shlobin, Oksana A.; Weir, Nargues; Aryal, Shambhu; Nathan, Steven D.; Brown, Anne; King, Christopher S.; Ahmad, Karem

doi:10.1016/j.chest.2018.08.382

Cited by 2 publications

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“…Interstitial lung disease represents one of the most harmful clinical manifestations in the course of CTDs, associated to very poor quality of life and increased mortality. [1][2][3] Although CTD-ILD represents an important field of research for both pulmonologists and rheumatologists, there is a lack of prospective data about prevalence, follow-up, and efficacy Among false negative cases, three patients had very advanced lung disease and the result of VECTOR probably derived from the difficulty to breathe deeply properly. The other two false negative cases included a patient with LIP and a patient with the only evidence of ground-glass at HRCT (without clear signs of fibrosis).…”

Section: Discussionmentioning

confidence: 99%

“…Interstitial lung disease (ILD) represents one of the more frequent pulmonary manifestations in connective tissue diseases (CTDs) and it is characterized by severe implications in morbility and overall prognosis. [1][2][3] To date, high-resolution computed tomography (HRCT) represents the gold standard for the diagnosis and the characterization of ILD; 4 moreover, an increasing role for radiology has been observed in the last years; it allows to classify the different possible patterns with high specificity 5 and to quantify the evolution over the time of the lung disease. 6 Citation: Manfredi Despite the potentially deep impact of lung involvement on clinical course and prognosis, a routine assessment of ILD is not properly defined for all CTDs.…”

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confidence: 99%

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Usefulness of Digital Velcro Crackles Detection in Identification of Interstitial Lung Disease in Patients With Connective Tissue Diseases

Manfredi¹,

Cassone²,

Vacchi³

et al. 2020

Arch Rheumatol

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Objectives This study aims to evaluate the diagnostic accuracy of the VECTOR software in patients with connective tissue diseases (CTDs), compared with the reference standard of high-resolution computed tomography (HRCT). Patients and methods The study included 98 consecutive patients of CTD (24 males, 74 females; median age 66 years; range, 24 to 85 years) with a recent HRCT. Patients were evaluated in a blindly manner by VECTOR and the results obtained by the algorithm were compared with the presence of interstitial lung disease (ILD) according to HRCT. Results Interstitial lung disease was detected in 42.8% of subjects. VECTOR correctly classified 81/98 patients, with a diagnostic accuracy of 82.6%; sensitivity and specificity were 88.1% and 78.6%, respectively. Only 5/42 patients with ILD were not correctly classified by VECTOR, while false positive cases were 21.4%. No significant differences were observed according to the radiologic pattern of ILD. Conclusion VECTOR showed high sensitivity, specificity and diagnostic accuracy, allowing selecting patients to be investigated with HRCT. The relatively high frequency rate of false positive results is acceptable if compared with the lack of effective screening methods for this complication of CTDs.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Usefulness of Digital Velcro Crackles Detection in Identification of Interstitial Lung Disease in Patients With Connective Tissue Diseases

Manfredi¹,

Cassone²,

Vacchi³

et al. 2020

Arch Rheumatol

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“…Referral and listing guidelines generalise between forms of ILD and incorporate factors associated with worse outcomes including lower/declining pulmonary function ( particularly FVC and diffusing capacity of the lung for carbon monoxide (D LCO )), higher oxygen needs, lower 6-min walk distance (6MWD), pulmonary hypertension (PH), history of pneumothorax or other respiratory hospitalisation, usual interstitial pneumonia pattern on HRCT, frailty and low performance status [13,27,[38][39][40][41][42][43][44] (table 1). Response or lack of response to antifibrotics should be considered.…”

Section: Introductionmentioning

confidence: 99%

Lung transplantation for interstitial lung disease

Kapnadak

Raghu

2021

Eur Respir Rev

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Lung transplantation (LTx) can be a life-extending treatment option for patients with advanced and/or progressive fibrotic interstitial lung disease (ILD), especially idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis, sarcoidosis and connective tissue disease-associated ILD. IPF is now the most common indication for LTx worldwide. Several unique features in patients with ILD can impact optimal timing of referral or listing for LTx, pre- or post-transplant risks, candidacy and post-transplant management. As the epidemiology of LTx and community practices have evolved, recent literature describes outcomes and approaches in higher-risk candidates. In this review, we discuss the unique and important clinical findings, course, monitoring and management of patients with IPF and other progressive fibrotic ILDs during pre-LTx evaluation and up to the day of transplantation; the need for co-management with clinical experts in ILD and LTx is emphasised. Some post-LTx complications are unique in these patient cohorts, which require prompt detection and appropriate management by experts in multiple disciplines familiar with telomere biology disorders and infectious, haematological, oncological and cardiac complications to enhance the likelihood of improved outcomes and survival of LTx recipients with IPF and other ILDs.

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Connective Tissue Disease-Associated Interstitial Lung Disease and Outcomes After Hospitalization: A Cohort Study

Cited by 2 publications

References 0 publications

Usefulness of Digital Velcro Crackles Detection in Identification of Interstitial Lung Disease in Patients With Connective Tissue Diseases

Usefulness of Digital Velcro Crackles Detection in Identification of Interstitial Lung Disease in Patients With Connective Tissue Diseases

Lung transplantation for interstitial lung disease

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