Connectional studies of the primate lateral geniculate nucleus: Distribution of axons arising from the thalamic reticular nucleus of <i>Galago crassicaudatus</i>

Harting, John K.; Lieshout, David P. Van; Feig, Sherry L.

doi:10.1002/cne.903100310

Cited by 57 publications

(74 citation statements)

References 41 publications

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“…However, not all of the reticular projections from the visual and somatosensory sectors are so highly organized. Thus, the projections from the visual sector to the pulvinar-lateral posterior complex (RodrigoAngulo and Reinoso- Suá rez, 1988;Conley and Diamond, 1990;Harting et al, 1991;FitzGibbon et al, 1995) and those from the somatosensory sector to the medial division of the posterior complex (POm; Pinault et al, 1995a;Crabtree, 1996) appear to lack a strict topography. In addition to their mapped and nonmapped projections, reticular cells in the visual and somatosensory sectors that project to different thalamic nuclei can occupy largely segregated (Conley and Diamond, 1990;Harting et al, 1991;Pinault et al, 1995a;Coleman and Mitrofanis, 1996) or overlapping (Crabtree, 1996) territories.…”

Section: Indexing Terms: Auditory Thalamus; Slabs; Projections; Collamentioning

confidence: 95%

Organization in the auditory sector of the cat's thalamic reticular nucleus

Crabtree

1998

J. Comp. Neurol.

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This study describes the organization of cells in the thalamic reticular nucleus (TRN) that project to the auditory part of the cat's dorsal thalamus. Injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) and fluorescent dyes were made into the medial geniculate complex (MG). The resultant retrograde labelling in the TRN was analyzed. Injections of WGA-HRP into the ventral (MGv), dorsal (MGd), or medial (MGm) nuclei of the MG label zones of cells that are restricted to a caudoventral sector of the TRN. In reconstructions, these zones resemble "slabs" that are elongated in the dorsoventral and oblique rostrocaudal dimensions of the nucleus. In comparisons of the zones of labelling in the TRN following tracer injections into different nuclei of the MG, inner and caudal cells project to the pars lateralis of the MGv (MGvl) or to the MGd, and outer and rostral cells project to the pars ovoidea of the MGv (MGvo) or to the MGm. Thus, cells projecting to the MGvl or MGd or to the MGvo or MGm occupy overlapping territories. Double injections of different fluorescent dyes into selected pairs of MG nuclei result in reticular cells that are labelled from either both nuclei or only one or the other nucleus in each pair. These results indicate that the projections of cells in the auditory sector of the TRN to the MGvl or MGvo or to the MGd or MGm are topographically organized. Furthermore, projections to more than one MG nucleus can arise from single reticular cells.

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Section: Indexing Terms: Auditory Thalamus; Slabs; Projections; Collamentioning

confidence: 95%

Organization in the auditory sector of the cat's thalamic reticular nucleus

Crabtree

1998

J. Comp. Neurol.

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“…TRN consists of a population of GABAergic cells (e.g., see Houser et al, 1980;Hendrickson et al, 1983;Oertel et al, 1983;Montero and Singer, 1984;Penny et al, 1984;Yen et al, 1985a) whose axons make F-type synapses (e.g., see Montero and Scott, 1981;Montero, 1983;Peschanski et al, 1983;Cucchiaro et al, 1991;Harting et al, 1991;Liu et al, 1995). These findings are consistent with the inhibitory influences that these cells have on dorsal thalamic nuclei (e.g., see Sumitomo et al, 1976;Lindstrom, 1982;Shosaku and Sumitomo, 1983;French et al, 1985;Shosaku, 1986;Lo and Xie, 1987;Lee et al, 1994a,b;Lo and Sherman, 1994;Warren and Jones, 1994).…”

Section: Functional Considerationsmentioning

confidence: 98%

Organization in the somatosensory sector of the cat's thalamic reticular nucleus

Crabtree

1996

J. Comp. Neurol.

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This study describes the organization of cells in the thalamic reticular nucleus (TRN) that project to the somatosensory part of the dorsal thalamus in the cat. Injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) and fluorescent dyes were made into the ventrobasal complex (VB) and the medial division of the posterior complex (POm) of the thalamus. The resultant retrograde labelling in TRN was analyzed. Large injections of a tracer in VB label many reticular cells that are restricted to a centroventral, or somatosensory, sector of TRN. Small injections of a tracer in VB produce narrow zones of labelled cells in this sector. In reconstructions these zones resemble thin "slabs," which lie parallel to the plane of TRN along its oblique rostrocaudal dimension and occupy only a fraction of its thickness. In comparisons of the zones of labelled cells in TRN resulting from tracer injections in different nuclei of VB, inner cells, intermediate cells, and outer cells across the thickness of TRN project to the ventral posteromedial, the medial division of the ventral posterolateral, and the lateral division of the ventral posterolateral nuclei, respectively. Furthermore, shifts in injected areas along the dorsoventral dimension of VB produce similar shifts in zones of labelled cells in TRN. Thus, reticular cells form an accurate map on the basis of their connections with VB. Large injections of a tracer in the ventral subdivision of POm label many reticular cells that are also restricted to the centroventral sector of TRN. Small injections of a tracer in ventral POm produce broad zones of labelled cells in this sector. In comparisons of the zones of labelled cells in TRN resulting from tracer injections in different regions of ventral POm, cells that project to these regions are scattered across the thickness of TRN and occupy overlapping territories. Large injections of a tracer in either VB or ventral POm also label cells in a restricted centroventral region of the perireticular nucleus. Double injections of different tracers in VB and ventral POm produce many cells in TRN that are labelled from both of these dorsal thalamic structures and fewer cells that are labelled from only one or the other of these structures. These results indicate that there is a dual organization in the projections of cells in the somatosensory sector of TRN to dorsal thalamus: Projections to VB are topographically organized whereas those to ventral POm lack a topographical organization. Furthermore, both of these mapped and nonmapped projections can arise from single reticular cells in the somatosensory sector.

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“…point very early in the visual pathway as its anatomical connections with LGN would predict (Jones, 1975;Conley and Diamond, 1990;Harting et al, 1991;Uhlrich et al, 2003). What is probably more important is that because this visual response has such a short latency and brief duration, the output of the TRN appears to be temporally tuned to act, in return, on early visual responses in the LGN.…”

Section: Trn Neuronal Activitymentioning

confidence: 99%

“…Visual TRN in the primate receives input from the visual thalamic relay [the lateral geniculate nucleus (LGN)] via LGN axon collaterals projecting to primary visual cortex (V1). The projection from V1 layer 6 back to LGN also sends collaterals to TRN (Conley and Diamond, 1990;Harting et al, 1991;Uhlrich et al, 2003). Both of these inputs to TRN are excitatory.…”

Section: Introductionmentioning

confidence: 99%

Attentional Modulation of Thalamic Reticular Neurons

McAlonan

Cavanaugh²,

Wurtz³

2006

J. Neurosci.

207

156

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The major pathway for visual information reaching cerebral cortex is through the lateral geniculate nucleus (LGN) of the thalamus. Acting on this vital relay is another thalamic nucleus, the thalamic reticular nucleus (TRN). This nucleus receives topographically organized collaterals from both thalamus and cortex and sends similarly organized projections back to thalamus. The inputs to the TRN are excitatory, but the output back to the thalamic relay is inhibitory, providing an ideal organization for modulating visual activity during early processing. This functional architecture led Crick in 1984 to hypothesize that TRN serves to direct a searchlight of attention to different regions of the topographic map; however, despite the substantial influence of this hypothesis, the activity of TRN neurons has never been determined during an attention task. We have determined the nature of the response of visual TRN neurons in awake monkeys, and the modulation of that response as the monkeys shifted attention between visual and auditory stimuli. Visual TRN neurons had a strong (194 spikes/s) and fast (25 ms latency) transient increase of activity to spots of light falling in their receptive fields, as well as high background firing rate (45 spikes/s). When attention shifted to the spots of light, the amplitude of the transient visual response typically increased, whereas other neuronal response characteristics remained unchanged. Thus, as predicted previously, TRN activity is modified by shifts of visual attention, and these attentional changes could influence visual processing in LGN via the inhibitory connections back to the thalamus.

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Connectional studies of the primate lateral geniculate nucleus: Distribution of axons arising from the thalamic reticular nucleus of Galago crassicaudatus

Cited by 57 publications

References 41 publications

Organization in the auditory sector of the cat's thalamic reticular nucleus

Organization in the auditory sector of the cat's thalamic reticular nucleus

Organization in the somatosensory sector of the cat's thalamic reticular nucleus

Attentional Modulation of Thalamic Reticular Neurons

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