Connecting the Dots: N6‐Methyladenosine (m⁶A) Modification in Spermatogenesis

Abstract

N6‐methyladenosine (m6A) is the most common RNA modification found in eukaryotes and is involved in multiple biological processes, including neuronal development, tumorigenesis, and gametogenesis. It is well known that methylation‐modifying enzymes (classified into writers, erasers, and readers) mediate catalysis, clearance, and recognition of m6A. Recent studies suggest that these genes may be associated with spermatogenesis. Numerous studies have revealed the m6A role during spermatogenesis. However, the expression patterns and relationships of these m6A enzymes during various stages of spermatogenesis remain unknown. In this review, it is aimed to provide an overview of m6A enzyme functions and elucidate their potential mechanisms and regulatory relationships at a specific phase during spermatogenesis, providing new insights into the m6A modification underlying the spermatogenesis process.