Conjunctival provocation test in diagnosis of peanut allergy in children

Abstract

Conjunctival allergen challenge appears to be feasible, accurate and safe in diagnosing children referred for suspected peanut allergy.

Feasibility of desensitizing children highly allergic to peanut by high‐dose oral immunotherapy

“…Children were recruited from February 2014 to June 2015 from the Oslo Peanut Allergy Study and from in‐house or other paediatric allergy clinics in Oslo and the surrounding area.…”

Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial

“…Exclusion criteria were non-controlled asthma or severe chronic disease including severe atopic eczema and diabetes mellitus. The screening investigations, described in detail in Appendix S1, included a structured interview, standardized QoL questionnaires, serological and immunologic analyses, lung function measurements, 20 SPT, and conjunctival allergen provocation test, 21 followed by a DBPCFC.…”

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy

“…36 Diagnosing food allergy remains a challenge with food provocation challenges frequently being required. 39 None had a severe adverse reaction with this approach where as a quarter had an anaphylactic reaction with the food challenge. 37 Another approach, which is become more established, is the basophil activation test which Santos and Shreffler reviewed.…”

“…38 There are some novel approaches, and Lindvik and colleague published data from 81 children demonstrating that conjunctival provocation testing has a sensitivity and the specificity of 0.96 and 0.83, respectively, for peanut allergy. 39 None had a severe adverse reaction with this approach where as a quarter had an anaphylactic reaction with the food challenge.…”