Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients

Abstract

Conjunctival melanoma is a rare malignancy with great potential for mortality in Chinese. Special attention should be paid to patients with tumor hemorrhage. Compared to Caucasians, Chinese patients exhibit more aggressive clinical signs with compromised prognosis.

Multicenter, International Assessment of the Eighth Edition of the American Joint Committee on Cancer Cancer Staging Manual for Conjunctival Melanoma

“…Ethnic/racial backgrounds were not collected as data; however, because the data were derived from 4 continents, the registry included a broad spectrum of patients. In contrast, Zhou et al 13 reported on mostly cT2 and cT3 tumors from the Chinese population. 5 , 7 …”

“…However, on subgroup analysis, the number of patients in the T3 group was insufficient for 5-year analysis. Although there are no multicenter data on cumulative mortality rates to date, previous single-center studies 2 , 3 , 5 , 7 , 13 , 14 have suggested that larger tumors are associated with a higher incidence of metastasis and mortality. All patients in whom primary tumor could not be assessed (ie, cTx and pTx categories) were censored for the calculation of mortality rates.…”

Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort

“…www.nature.com/scientificreports/ slightly higher 5-year cancer-specific survival ranging from 70 to 80%. On the contrary for CM, poorer survival outcomes have been reported in Asians compared to Caucasians, due in part to the advanced stages at presentation and poor melanoma awareness in Asia 15,17 . In our cohort, the 5-year RFS and OS for CM (n = 14) are 30.1% and 68.8%, respectively.…”

“…Asian-specific studies on ocular melanoma at present remain scarce. Asian reports on UM include those from China 11,12 and South Korea 13,14 , while those on CM include those from China 15,16 and India 17 . Compared to Western cohorts, Asian patients presented at an earlier age for both UM and CM 11,17 .…”

“…Compared to Western cohorts, Asian patients presented at an earlier age for both UM and CM 11,17 . The prognosis of Asian patients however, vary across studies and remains to be better defined 11,14,15 .…”