Conjunctival malt lymphoma successfully treated with single agent rituximab therapy

Salepçi, Taflan; Şeker, Mesut; Kurnaz, Ekrem; Guler, Derya; Bılıcı, Ahmet; Dane, Faysal; Aliustaoğlu, Mehmet; Atesoglu, Elif Birtas; Gümüş, Mahmut; Yaylacı, Mustafa

doi:10.1016/j.leukres.2008.05.018

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…It is very well tolerated. Most case reports in which rituximab was delivered in this manner in the treatment of newly diagnosed OAL revealed a 100% overall response rate [117–119, 122, 125, 126, 140]. However, a Ferreri et al study calls into question the long-term efficacy of this treatment.…”

Section: Reviewmentioning

confidence: 99%

Classification, diagnosis, and management of conjunctival lymphoma

2019

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Lymphoma is a malignant lymphoproliferative tumor that can involve the conjunctiva. Approximately 5–15% of all extranodal lymphomas are found in the ocular adnexal region, with approximately 25% of those involving the conjunctiva. Ninety-eight percent of conjunctival lymphomas arise from B-lymphocytes. The most common subtype of conjunctival lymphoma is extranodal marginal zone lymphoma (80%), followed by follicular lymphoma (8%), diffuse large B-cell lymphoma (3%) and mantle cell lymphoma (3%). Natural killer and T cells (NK/T) are rare causes of lymphoma. While most conjunctival lymphomas are localized to the ocular adnexa at the time of presentation, systemic examination and management are of key importance in the long-term care of the patient. This review outlines the classification, etiology, presentation, diagnosis, and management of conjunctival lymphoma. The novel use of high resolution optical coherence tomography, both as a diagnostic tool and as a means for ongoing evaluation during treatment, is illustrated. Treatment options discussed include external beam radiation, chemotherapy, immunotherapy, antibiotic therapy, and combination regimens. Future investigation of the etiology and pathogenesis of conjunctival lymphoma is expected to reveal opportunities for innovative and individualized therapeutic agents. Collaboration between multiple disciplines is key in the advancement of the field.

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Section: Reviewmentioning

confidence: 99%

Classification, diagnosis, and management of conjunctival lymphoma

2019

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“…For an IgH-translocated ophthalmic MALT lymphoma, aggressive treatment is necessary due to the high-risk of tumor progression (13). MALT lymphomas are sensitive to external beam radiation, chemotherapy, cryotherapy and oral doxycycline for Chlamydia infection (1,9), and the systemic anti-CD20 antibody, rituximab, is reserved for refractory MALT lymphomas (14). In the present case, to avoid radiation-related ocular complications, a topical ciprofloxacin and steroid were chosen to treat the conjunctival MALT lymphoma, and radiotherapy was given covering bilateral neck, left nasal cavity, and left lacrimal sac.…”

Section: Discussionmentioning

confidence: 99%

Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

Hsieh

Liao

et al. 2016

Oncology Letters

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Abstract. The aim of the present study was to report a rare case of single-clone, immunoglobulin heavy chain (IgH)-rearranged mucosa-associated lymphoid tissue (MALT) lymphoma in the conjunctiva, with nasal cavity dissemination through the nasolacrimal duct. A 24-year-old female was diagnosed with MALT lymphoma of the nasal cavity at the Department of Otolaryngology, Wan Fang Medical Center, Taipei Medical University (Tapei, Taiwan) in October 2008. A biopsy of the relapsing conjunctival lesion revealed a MALT lymphoma by pathological staining, while a single-clone, IgH-rearranged tumor lesion in the nasal cavity and conjunctiva was confirmed using continuous sinus computed tomography scans and polymerase chain reaction. Tumor lesions were negative for Helicobacter pylori and Chlamydia infection, but exhibited bilateral neck lymph node dissemination. A combination of radiation therapy (a total dosage of 46.8 Gray, in two phases covering the left lacrimal sac, nasal cavity and bilateral neck region) and topical ciprofloxacin plus steroid (0.3% ciprofloxacin 4 times a day and betamethasone eye ointment before sleep for 1 month) was provided as an effective therapeutic strategy, and no recurrence was found in the next 3 years. The nasolacrimal duct serves as a channel for conjunctival tumor spreading and is easily neglected. IgH-involved translocation in MALT lymphoma is a factor in the progression of the disease, and aggressive combination therapy is essential for a high-risk, disseminated IgH-rearranged MALT lymphoma.

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“…Occasionally, presenting symptoms could be relevant, thus requiring an immediate treatment. Surgical resection, radiotherapyandoralchlorambucilarethemostfrequentlyapplied therapeuticstrategiesforOAML.Withthesestrategies,clinicalbehaviorofOAMLisusuallyfavorable.Newexperimentaltherapeuticstrategieswererituximab [17],bacteria-eradicating antibiotic therapy, anti-hepatitis C virus (HCV) therapy, and intralesional injections of interferon. These approachescouldbeassociatedwithalowerincidenceofsevere sequelae.Thetherapeuticdecisionshouldresultfromawellbalancedanalysisofpatient-andlymphoma-relatedvariables, as well as the risk of treatment-related toxicity [18].…”

Section: Acknowledgementmentioning

confidence: 99%

Bilateral Conjunctival MALT Lymphoma Mimicking Chronic Conjunctivitis

Şeker¹,

Özdemir

Bılıcı³

et al. 2010

Onkologie

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Background: The diagnosis of conjunctival lymphoid tu-mors is straightforward when they present with a characteristic salmon-pink, pebbly, multinodular appearance. However, rarely a diffuse clinical presentation is encountered, and this may mimic chronic conjunctivitis of other etiologies. Case Report: A 60-year-old man was referred to our clinic with bilateral conjunctival masses in May 2005. With the assumption of chlamydial conjunctivitis, without microbiological or histopathological evidence, tetracycline ointment and oral doxycycline 100 mg twice daily were prescribed. Although a partial response was achieved, 2 months after the treatment, the patient’s complaints returned. On second referral to our clinic in March 2006, the patient was re-evaluated. He presented with bilateral conjunctival masses resembling conjunctival lymphoma, and a bilateral diagnostic biopsy was performed. Histopathological evaluation of the biopsy specimens revealed mucosa-associated lymphoid tissue (MALT) lymphoma. The patient received CVP chemotherapy (cyclophosphamide, vincristine, prednisolone). After 6 courses of chemotherapy, he achieved partial remission in both eyes. Currently, 28 months after CVP, sustained remission is obtained. Conclusions: In these cases, a high index of suspicion is required if one is to avoid a delay in diagnosis, and the importance of correct early diagnosis is obvious.

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Conjunctival malt lymphoma successfully treated with single agent rituximab therapy

Cited by 17 publications

References 11 publications

Classification, diagnosis, and management of conjunctival lymphoma

Classification, diagnosis, and management of conjunctival lymphoma

Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

Bilateral Conjunctival MALT Lymphoma Mimicking Chronic Conjunctivitis

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