Conjunctival intraepithelial and invasive squamous cell carcinomas treated with strontium-90

Beta therapy with 90strontium as single modality therapy for canine squamous cell carcinoma in third eyelid

“…Recurrence was also reported in 5 of 38 horses, at an average of 449 days post-radiation (ranging from 29 days to 900 days) (MOSUNIC et al, 2004). The recurrence rate among patients of this study was low, suggesting that topical beta-radiation can be an effective treatment modality for SCC of the third eyelid in dogs, similarly to conjunctival carcinoma in human patients (CEREZO et al, 1990). Petsuksiri et al (2008) related the primary radiotherapy for SCC of the eyelid in human patients, and the report concluded that the radiotherapy provides excellent locoregional control with reasonable complications rates and should be considered an alternative to surgery in selected patients.…”

“…Tumor recurrence was diagnosed at 150 days (dog#7) and 352 days (dog# 8) post-radiation. The radiation dosages and optimal radiation delivery protocols for conjunctival tumors in dogs have not been established (CEREZO et al, 1990). Our results suggest that the dose and fractionation protocols empirically used in these 9 patients can be curative in cases of canine third eyelid SCC, with minimal side effects.…”

“…Keratitis, periocular dermatitis and cataract have been described in human patients with conjunctival lymphoma treated with beta-radiation (REGUEIRO et al, 2002). The characteristics of the beta-ray emissions then, limited penetration that makes Strontium-90β so suitable for superficial ophthalmic applications (CEREZO et al, 1990) might have contributed to absence of cataracts among the patients of this study. Also, the treatment was carried out on the third eyelid surface and not on the sclera or conjunctiva where the proximity to the lens would be greater increasing the risk of lens damage.…”

“…Sedation and topical anesthesia allowed completion of the procedure without complications. SCCs are of epithelial origin, and therefore responsive to radiation therapy, making these tumors ideal targets for local radiation (CEREZO et al, 1990).…”

Conjunctival–Corneal Intraepithelial Neoplasia (Bowen Disease) Treated With Orthovoltage

“…In 1978, Barahona Hortelano et al 6 reported a case treated with radioactive isotopes. In 1990, a more extensive series was reported by Cerezo et al, 7 with excellent results in 27 patients treated with betatherapy. We have not found any more recent references on the use of radiotherapy with orthovoltage in this location.…”