Conjunctival impression cytology, ocular surface and tear-film changes in patients with lichen planus

Şanlı, Berna; Çetin, Ebru; Bir, Ferda; Taşlı, L.; Yaldızkaya, Filiz; Yaylalı, Volkan

doi:10.1111/j.1365-2230.2011.04274.x

Cited by 15 publications

(21 citation statements)

References 15 publications

(42 reference statements)

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“…[3][4][5] Because there are no pathognomonic signs, a conjunctival biopsy examined by histology and direct immunofluorescence is required to differentiate LP from other causes of cicatrical conjunctivitis, such as mucous membrane pemphigoid. 6 To date, only 7 adult cases of isolated conjunctival LP have been reported in adults. 1,[7][8][9] Ocular LP, irrespective of site, needs to be managed aggressively with immunosuppressive agents, because chronic ocular inflammation may lead to progressive subepithelial fibrosis, symblepharon, secondary ocular dryness, entropion, trichiasis, and corneal opacification, which may in turn lead to severe visual impairment.…”

Section: Discussionmentioning

confidence: 99%

Isolated ocular lichen planus in a child

Kennedy

MacDermott

Murphy

2015

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionmentioning

confidence: 99%

Isolated ocular lichen planus in a child

Kennedy

MacDermott

Murphy

2015

Journal of American Association for Pediatric Ophthalmology and

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“…Lichen planus may affect the ocular surface due to the conjunctival involvement. Rarely, conjunctival inflammation and subepithelial scarring may occur secondary to conjunctival involvement and keratitis, and keratoconjunctivitis may develop due to corneal involvement [7]. There is only one case-control study evaluating the ophthalmological findings in LP.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, LP may cause lacrimal canal pathologies and epiphora [5, 6]. The number of case-control studies about the effects of LP on the eye is quite limited up to now [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ocular findings in patients with lichen planus

Özlü¹,

Teberik²

2019

pdia

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Introduction Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology. Aim To evaluate the tear functions and the retinal and choroidal thickness (CT) in patients with LP. Material and methods In total, 33 patients and 30 healthy controls were enrolled. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer 1 test (with anesthesia), tear break-up time (TBUT) test, intraocular pressure (IOP), axial length (AL), and central corneal thickness (CCT). The measurements of retinal thickness (RT) and CT were obtained by spectral domain optical coherence tomography. Results No significant difference was observed between the groups in IOP, AL, CCT, or RT ( p > 0.05 in each group). There was a significant difference in the Schirmer 1 test, TBUT, and OSDI questionnaire ( p < 0.05 in each group). Choroidal thickness in LP patients was thinner than that in the controls ( p = 0.001 in each location). There was a moderate negative correlation between the disease duration and Schirmer 1 test, TBUT, and subfoveal CT ( r = –0.426, r = –0.555, r = –0.637; p = 0.001, p = 0.001, p = 0.001, respectively). There was a moderate negative correlation between the oral mucosal involvement and Schirmer 1 test, TBUT, and subfoveal CT ( r = –0.345, r = –0.392, r = –0.467; p = 0.006, p = 0.001, p = 0.001, respectively). There was a positive correlation between disease duration, oral mucosal involvement and OSDI score ( r = 0.717, r = 0.345; p = 0.001, p = 0.006, respectively). Conclusions Lichen planus may influence tear function tests and may cause dry eye. Patients with LP had lower CT values than healthy controls. Further studies are needed to clarify the effect of LP on the eyes.

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“…LP'un oküler ve gastrointestinal sistem tutulumu çok nadir olup bugüne kadar bu tutulumları gösteren az sayıda da olsa vaka bildirimleri mevcuttur. Oküler tutulum ise bugüne kadar kombine veya izole 19 farklı yayında bildirilmiştir (Tablo 2) [5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. LP'da konjonktival tutulum çok nadir olup tutulan konjonktivadaki mikroskopik bulgular da çok iyi tanımlanmamıştır.…”

Section: Gereç Ve Yöntemunclassified

Investigation of Conjunctival Involvement in Patients with Lichen Planus Without Ocular Symptoms

Özuğuz¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Liken planus (LP); tek ya da gruplar halinde, mor-menekşe renginde, parlak, köşeli, düz yüzeyli ve kaşıntılı papüllerle karakterize, en sık ekstremitelerin fleksör yüzlerinde, müköz membranlarda ve saçlı deride yerleşen bir dermatozdur. Müköz membran lezyonları çok yaygın olup vakaların %30-70'inde gelişir. Deri lezyonları olmaksızın da sık görülebilir ve vakaların %15-25'inde hastalığın tek belirtisi olarak karşımıza çıkabilir. Bukkal mukoza ve dil en yaygın tutulan alanlar olmakla birlikte lezyonlar anüs, genital bölge, mesane, vajina, konjonktiva, larenks ve nadiren kulağın timpanik membranı ve hatta özo-fagusta da yer alabilirler. Çalışmamızda klinik ve histopatolojik olarak LP olan ve asemptomatik olgularda konjonktival tutulumu araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 31 LP'lu hasta ile yaş ve cinsiyet uyumlu 16 sağlık-lı birey alındı. Kontrol grubu ve hastaların her iki göz kapağından lokal anestezi altında konjonktival kazıntı alınıp sitospin toplama sıvısında saklanarak immünohistokimyasal yöntemle lenfosit hücre sayımı yapıldı. Hasta ve kontrol grubundan elde edilen veriler Mann-Whitney U testi ile karşılaştırıldığın-da sonuç istatistiksel olarak anlamlı bulundu. Tartışma: Çalışmamız, klinik olarak göz yakınmaları olmayan LP'lu hastalarda histopatolojik olarak tutulumun saptanması ile hastalığın tüm müköz membranları tutabileceği görü-şünü desteklemiştir. Anahtar Kelimeler

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Conjunctival impression cytology, ocular surface and tear-film changes in patients with lichen planus

Cited by 15 publications

References 15 publications

Isolated ocular lichen planus in a child

Isolated ocular lichen planus in a child

Evaluation of ocular findings in patients with lichen planus

Investigation of Conjunctival Involvement in Patients with Lichen Planus Without Ocular Symptoms

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