Conjunctival Epithelial Basement Membrane Zone Immunohistology: Normal and Inflamed Conjunctiva

Cs, Foster; Je, Dutt; Ba, Rice; Ae, Kupferman; Lane, Laura A.

doi:10.1097/00004397-199403430-00019

Cited by 7 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike in skin and the oral mucosa, where the presence of subepithelial fibrinogen is abnormal and in itself very suggestive of LP, subepithelial fibrinogen in the conjunctiva has been shown to be a normal feature. 5 With conjunctival specimens, it is vital to not look just for the presence or absence of fibrinogen, but rather its morphology. A fibrinogen layer with spikes, spurs, fragmentation, reduplication, or a shaggy appearance is more likely to be consistent with a diagnosis of LP.…”

Section: Discussionmentioning

confidence: 99%

“…Conjunctival involvement with LP is a relatively rare feature of the disease, with 64 cases described in the literature and the vast majority of patients presenting with cicatricial changes. 5,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24 Even more uncommonly reported is LP with lacrimal drainage system involvement. Only 11 such patients have been described in various case reports and series 9,10 before Durrani et al (2008) performed a retrospective review of 184 patients with canalicular obstruction.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunopathology and histopathology of conjunctival biopsies in patients with presumed idiopathic punctal stenosis

et al. 2016

View full text Add to dashboard Cite

Background/Aims Numerous processes have been implicated as causes of punctal stenosis. Recent studies have highlighted inflammation in punctoplasty specimens in patients with punctal stenosis. Conjunctival biopsy has been suggested as a means to determine underlying etiologies, although little is known regarding what conjunctival pathologies are associated with punctal stenosis. Our objective is to examine the pathologic and immunologic findings in conjunctival biopsy specimens in patients with presumed idiopathic punctal stenosis. Methods A retrospective chart review was performed at a single institution over a five year period of patients with presumed idiopathic punctal stenosis who underwent conjunctival biopsy for routine histopathologic and/or direct immunofluorescent (DIF) examination. Patients with known etiologies of punctal stenosis were excluded. Results 23 patients met inclusion criteria. Conjunctival biopsies (n = 36) from all 23 patients underwent histological examination. 35 of 36 specimens (97.2%) showed a lymphocytic infiltrate. Two patients (8.7%) had findings suggestive of sarcoidosis. Conjunctival biopsies from 18 of the 23 patients were also evaluated by DIF. Nine patients (50.0%) had fibrinogen characteristics suggestive of lichen planus. There were no complications related to the conjunctival biopsy procedures. Conclusion Conjunctiva appears to be an excellent proxy in the evaluation of patients with presumed idiopathic punctal stenosis. The biopsy is safe and provides ample tissue. 11 of the 23 patients in this study demonstrated findings consistent with underlying immunologic disorders, suggesting that conjunctival biopsy may play a role in identifying the underlying etiology of punctal stenosis. Knowledge of these underlying conditions impacted medical and surgical treatments for several patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunopathology and histopathology of conjunctival biopsies in patients with presumed idiopathic punctal stenosis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Ла бо ра то риј ско до ка зи ва ње је врше но кул ти ви са њем ви ру са у кул ту ра ма HeLa-ће ли ја уз ти пи чан ци то па то ге ни ефе кат. Ци то ло шки на лаз је у не ко ли ко слу ча је ва ука зао на не спе ци фич ну акут ну ин фек ци ју, са за па љењ ском ре ак ци јом на јед ном оку, рет ким не у тро фи ли ма, лим фо ци ти ма, пла змо ци ти ма и џи нов ским епи те ло ид ним ће ли ја ма [10]. За от крива ње ви ру са ко ри шће не су сле де ће се ро ло шке ме то де: ELI SA-тест, тест фик са ци је ком пле ме на та, тест ин хиби ци је хе ма глу ти ни ци је, лан ча на ре ак ци ја по ли ме разе IL8-Csrc [11,12].…”

Section: методе радаunclassified