Conjunctival Deposits as the First Sign of Systemic Sarcoidosis in a Pediatric Patient

Çaça, İhsan; Ünlü, Kaan; Büyükbayram, Hüseyin; S, Ari

doi:10.1177/112067210601600128

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…The data on conjunctival biopsies in children in sarcoidosis is limited to case reports. One case report presented a 10-year-old female patient with conjunctival deposits but with no other ocular or systemic complaints, in whom conjunctival biopsies proved systemic sarcoidosis [ 126 ]. Another case report showed noncaseating lipogranulomatous subconjunctival nodules as a novel presenting finding in Blau syndrome in the absence of uveitis [ 127 ].…”

Section: Diagnostic Modalitiesmentioning

confidence: 99%

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Bazewicz,

Heissigerova,

Pavesio

et al. 2023

J Ophthal Inflamm Infect

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Sarcoidosis-associated uveitis, is the predominant ocular sarcoidosis presentation, which affects both adults and children. For adults, international ocular sarcoidosis criteria (IWOS) and sarcoidosis-associated uveitis criteria (SUN) are defined. However, for children they are not yet established internationally. Due to the specificity of pediatric manifestations of sarcoidosis, this task is even more challenging. In children, sarcoidosis is subdivided into Blau syndrome and early-onset sarcoidosis (BS/EOS) affecting younger children (< 5 years) and the one affecting older children with clinical presentation resembling adults. Differential diagnosis, clinical work-up as well as diagnostic criteria should be adapted to each age group. In this article, we review the clinical manifestation of sarcoidosis-associated uveitis in adults and children and the sensitivity and specificity of various ocular sarcoidosis diagnostic modalities, including chest X-ray and CT, FDG PET-CT, gallium-67 scintigraphy, bronchoalveolar lavage fluid, genetic testing for NOD2 mutations and serum biomarkers, such as ACE, lysozyme and IL2R.

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Section: Diagnostic Modalitiesmentioning

confidence: 99%

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Bazewicz,

Heissigerova,

Pavesio

et al. 2023

J Ophthal Inflamm Infect

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Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells

Massumi

Hoveizi

Baktash

et al. 2014

Experimental Cell Research

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Sarcoidosis presenting with granulomatous uveitis induced by pegylated interferon and ribavirin therapy for hepatitis C

Yan

Dinihan

Freiman

et al. 2008

Internal Medicine Journal

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Sarcoidosis is a systemic granulomatous disease that is triggered by an autoimmune process, and is now a well recognized but uncommon complication of antiviral therapy for Hepatitis C virus (HCV) infection, likely related to its immunomodulatory effects. The clinical presentation of HCV related sarcoidosis is as varied as systemic sarcoidosis, but ocular presentation alone has not been reported previously. We present a 23 year-old female who developed visual disturbances due to ocular sarcoidosis during the course of antiviral therapy for chronic HCV infection. Our case presentation is then followed by a review of the literature on the topic. We aim to stress the importance of screening for eye problems in following HCV patients undergoing antiviral therapy, and raise clinicians' awareness of sarcoidosis as a possible cause for eye problems even in the absence of respiratory complaints.

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Conjunctival Deposits as the First Sign of Systemic Sarcoidosis in a Pediatric Patient

Abstract: To the authors' knowledge, this is the second study that reports a sarcoidosis patient with non-systemic involvement diagnosed after histopathologic analysis of conjunctival deposits.

Cited by 3 publications

References 6 publications

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells

Sarcoidosis presenting with granulomatous uveitis induced by pegylated interferon and ribavirin therapy for hepatitis C

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