Conjunctival and Corneal Calcific Deposits in Uremic Patients

Harris, Laurence S.; Cohn, Kenneth H.; Toyofuku, Hidenao; Lonergan, E. T.; Galin, Miles A.

doi:10.1016/0002-9394(71)91602-3

Cited by 26 publications

(11 citation statements)

References 5 publications

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“…In chronic renal failure eye calcifications have been reported in the conjunctiva, cornea, and the sclera (Potts, 1972;Porter and Crombie, 1973;Demco et al, 1974;Harris et al, 1971). Given this patient's renal condition at the time of her death, it is certainly possible that her compromised renal status may also have been a factor in the scleral calcium deposition.…”

mentioning

confidence: 91%

Scleral and choroidal calcifications in a patient with pseudohypoparathyroidism.

Wong¹,

Zakov²,

Albert³

1979

British Journal of Ophthalmology

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Pseudohypoparathyroidism was initially suspected because of the characteristic habitus of truncal obesity, round facies, shortening of the fourth metatarsals, recurrent subcutaneous calcifications in the extremities, mental retardation with an IQ of 67, and biochemical abnormalities of hypocalcaemia (7 2 mg/100 ml (1 8 mmol/1); normal 9 0 to 11-5 mg/100 ml (2 25 to 2 87 mmol/l)), and hyperphosphataemia (9 7 mg/100 ml (3 13 mmol/l); normal 3 0 to 4 5 mg/l00 ml (0 97 to 1 45 mmol/l)). No eye abnormalities were noted on examination at that time. At the time of her diagnosis the patient was begun on supplemental vitamin D of 50 000 units per day. While she was on this regimen her serum calcium levels were found to be in the range of 8 to 10 mg/l00 ml (2 to 2 5 mmol/l), while her

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mentioning

confidence: 91%

Scleral and choroidal calcifications in a patient with pseudohypoparathyroidism.

Wong¹,

Zakov²,

Albert³

1979

British Journal of Ophthalmology

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“…7 Harris et al 3 stated that chronic hemodialysis did not influence the calcium deposits in uremic patients. However, in our case, prompt treatment of the hypercalcemia reduced the corneal opacities.…”

Section: Discussionmentioning

confidence: 98%

“…Over 80% of severely uremic patients develop corneal and conjunctival calcific deposits. 3 Diffuse opacification of the peripheral limbal area and interpalpebral zone is a typical conjunctival and corneal change associated with chronic renal failure. 4 Deposition of calcium salts on the ocular surface depends not only on the solubility product of calcium and phosphate but also on altered tissue physiology.…”

Section: Discussionmentioning

confidence: 99%

Atypical corneal subepithelial calcium deposits in a patient with sarcoidosis

Ida¹,

Kato²,

Ishikawa³

et al. 2014

Journal of Cataract and Refractive Surgery Online Case Reports

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“…Diffuse calcification of the conjunctiva and cornea is not only a recognised manifestation of hypercalcaemia (Klintworth 1994) but has been reported in uraemic patients with low or normal serum calcium levels (Harris et al 1971). It usually takes 8-10 weeks to become clinically evident but, on occasion, can develop in a period as short as 24 hours.…”

Section: Discussionmentioning

confidence: 99%

Histological findings in the eyelids of aids patients

Pecorella

Ciardi

Maedsco

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The eyelids of 15 AIDS patients (17 specimens) were examined histologically at postmortem. Methods: Formalin-fixed, paraffin-embedded and haematoxylin-eosin stained sections were examined by conventional light microscopy. The presence of calcific deposits was confirmed by special stains and elemental analysis (X-ray energy dispersive spectroscopy). Results: 6 cases had abnormal microscopical findings. In two cases deposits of calcium oxalates were observed in the wall of dermal blood vessels and in epithelial cells of sweat and sebaceous glands, respectively. Precipitates of calcium phosphate were observed in the superficial substantia propria of the palpebral conjunctiva in an additional patient. Other histological findings in the remaining three patients included flat warts, an unusual elastotic degeneration of the forniceal palpebral conjunctiva and more common lesions (chalazion, Demodex folliculorum infestation of the eyelashes, trichilemmal cyst). Conclusion:The presence of microscopical lesions in nearly half of this small series demonstrates that the eyelids may be affected subclinically in AIDS patients.

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Conjunctival and Corneal Calcific Deposits in Uremic Patients

Cited by 26 publications

References 5 publications

Scleral and choroidal calcifications in a patient with pseudohypoparathyroidism.

Scleral and choroidal calcifications in a patient with pseudohypoparathyroidism.

Atypical corneal subepithelial calcium deposits in a patient with sarcoidosis

Histological findings in the eyelids of aids patients

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