Conjugation of Triphenylphosphonium Cation to Hydrophobic Moieties to Prepare Mitochondria-Targeting Nanocarriers

Guzmán-Villanueva, Diana; Mendiola, Mark R; Nguyen, Hong C.; Yambao, Francis; Yu, Nusem; Weissig, Volkmar

doi:10.1007/978-1-4939-9516-5_12

Cited by 11 publications

(10 citation statements)

References 22 publications

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“…TPP is most frequently employed in decorating the surfaces of polymeric nanoparticles for mitochondria targeting, primarily due to its straightforward linking with different kinds of polymers (Guzman-Villanueva et al, 2019). Biswas et al designed a mitochondria-targeted poly (amidoamine) (PAMAM) dendrimer modified with TPP (Biswas et al, 2012).…”

Section: Tpp-based Mitochondria-targeted Deliverymentioning

confidence: 99%

“…However, the highly positive charge of TPP-modified nanoparticles also results in quick blood clearance and thusly reduced accumulation at tumor sites. Moreover, these positive charged nanomedicines effortlessly bind to multiple biomacromolecules with negative charge during blood circulation, causing increased toxicity to normal cells (Guzman-Villanueva et al, 2019). Zhou et al developed hybrid nanoparticles composed of poly (D,L-lactide-coglycolide) (PLGA), TPP-containing polymer (C18-PEG-TPP) and a redox-responsive amphiphilic polymer (DLPE-S-S-PEG), in which the positive charges of TPP were shielded by the longer PEG chain, ensured prolonged blood circulation and reduced side effects (Zhou et al, 2017).…”

Section: Tpp-based Mitochondria-targeted Deliverymentioning

confidence: 99%

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Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Sun

Yang

Xia

et al. 2021

Front. Bioeng. Biotechnol.

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Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.

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Section: Tpp-based Mitochondria-targeted Deliverymentioning

confidence: 99%

Section: Tpp-based Mitochondria-targeted Deliverymentioning

confidence: 99%

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Sun

Yang

Xia

et al. 2021

Front. Bioeng. Biotechnol.

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“…Other nanostructures may need surface modification to create a coating of targeting ligands that direct the structure to the mitochondria. Specific drug delivery to mitochondria has been propelled by triphenylphosphonium (TPP), which is a lipophilic cation widely studied as a mitochondria-targeted agent [154,155]. Diverse TPP-linked antioxidants based on natural hydroxycinnamic derivatives have shown preferential mitochondrial localization and enhanced protection against oxidative damage and mitochondrial defects compared to free molecules both in cellular and animal models as well as in ex vivo assay with samples from NI&NDDs patients [156][157][158][159][160][161].…”

Section: Nanosystems To Counteract the Oxidative Stress Associated With Mitochondrial Dysfunction In Niandnddsmentioning

confidence: 99%

Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

2021

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Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated that structural and functional mitochondrial disturbances are involved in the development of different neuroinflammatory (NI) and neurodegenerative (ND) diseases (NI&NDDs) such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Remarkably, counteracting mitochondrial impairment by genetic or pharmacologic treatment ameliorates neurodegeneration and clinical disability in animal models of these diseases. Therefore, the development of nanosystems enabling the sustained and selective delivery of mitochondria-targeted drugs is a novel and effective strategy to tackle NI&NDDs. In this review, we outline the impact of mitochondrial dysfunction associated with unbalanced mitochondrial dynamics, altered mitophagy, oxidative stress, energy deficit, and proteinopathies in NI&NDDs. In addition, we review different strategies for selective mitochondria-specific ligand targeting and discuss novel nanomaterials, nanozymes, and drug-loaded nanosystems developed to repair mitochondrial function and their therapeutic benefits protecting against oxidative stress, restoring cell energy production, preventing cell death, inhibiting protein aggregates, and improving motor and cognitive disability in cellular and animal models of different NI&NDDs.

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“…Non-specific toxicity due to the excessive accumulation of the TPP cations within mitochondria has also been highlighted as an issue with this carrier. 14 Based upon this prior work, the incorporation of the acenaphthalene moiety into the oCOm structure would result in a fluorescent by-product after loss of HBr and CO allowing for the determination of cellular location utilising water soluble compounds that also avoid the bulky TTP carrier.…”

Section: Introductionmentioning

confidence: 99%

Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules

et al. 2022

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Conjugation of Triphenylphosphonium Cation to Hydrophobic Moieties to Prepare Mitochondria-Targeting Nanocarriers

Cited by 11 publications

References 22 publications

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules

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