Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy

Santana, Willian Max O.S. de; Caetano, Bruno Leonardo; Annunzio, Sarah Raquel de; Pulcinelli, Sandra Helena; Ménager, Christine; Fontana, Carla Raquel; Santilli, Celso Valentim

doi:10.1016/j.colsurfb.2020.111297

Cited by 24 publications

(23 citation statements)

References 64 publications

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“…Although MFe 2 O 4 nanoparticles have exhibited excellent characteristics in the biomedical field, their safe application in the human body is a major problem owing to the heavy metal elements presented in MFe 2 O 4 [1], which also limits their applications in the biomedical field. So, as one of the typical nanomaterials, spinel iron oxide nanoparticles without heavy metal elements have been widely applied in many aspects of the biomedicine field due to their good biocompatibility and no toxicity or low toxicity in organisms [2,3], such as magnetic resonance imaging (MRI) [4], clinical diagnosis and the treatment of diseases [5,6], magnetic carriers for drug targeting [7], catalysis [8][9][10][11][12], immune assays [13], targeting photodynamic therapy [14][15][16], cell separation [17], DNA extraction [18], and so on. Therefore, the preparations and applications of iron oxide nanoparticles have attracted more and more researchers [19,20].…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic α-Fe2O3/Fe3O4 Heterogeneous Nanoparticles with Enhanced Biocompatibility

Wang

Liu

2021

Nanomaterials

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A novel type of magnetic α-Fe2O3/Fe3O4 heterogeneous nanoparticles was prepared via a facile solution combustion process with ferric nitrate and urea as raw materials, and they were characterized by XRD, SEM, TEM, and VSM techniques. The effects of the calcination temperature, the calcination time, the ratio of ferric nitrate and urea, and the heating rate on the relative content of Fe3O4 in the heterogeneous nanoparticles were investigated. The toxicity of α-Fe2O3/Fe3O4 heterogeneous nanoparticles to human hepatocytes L-02, the blood routine, and the histopathological section observation of mice were explored. The results showed that the ratio of ferric nitrate and urea was a key factor to affect the relative content of Fe3O4 in the heterogeneous nanoparticles. The calcination temperature and the calcination time had similar influences, and the corresponding calcination temperature and the calcination time were selected according to their own needs. The CCK8 results initially revealed that α-Fe2O3/Fe3O4 heterogeneous nanoparticles had no effect on cell viability when the concentration of the heterogeneous nanoparticles was less than 100 ng/mL, which suggested their excellent biocompatibility. At the same time, the tail vein administration concentration of 0.9 mg/kg had good biological safety.

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Section: Introductionmentioning

confidence: 99%

Superparamagnetic α-Fe2O3/Fe3O4 Heterogeneous Nanoparticles with Enhanced Biocompatibility

Wang

Liu

2021

Nanomaterials

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“…PDT has been used in combination with several non-invasive therapeutic approaches with additive and synergistic efficacy and enhancement of outcomes in most studies conducted in vitro, as well as in preclinical and clinical applications [ 71 ]. In this regard, studies and applications have been reported for aPDT in combination with antibiotic chemotherapy [ 72 ] PTT [ 73 ], MHT [ 74 ], CAP [ 75 , 76 ], and endodontic debridement [ 77 ]. Studies and applications have also been reported in combinations using multiple PDT photosensitizers, in what could be termed multiple photosensitizer combination aPDT.…”

Section: Combination Therapies With Antimicrobial Photodynamic Therapymentioning

confidence: 99%

“…A nanoconjugate consisting of superparamagnetic iron oxide nanoparticles capped with the photosensitizer curcumin showed magneto-thermal conversion upon application of an alternating magnetic field and excellent PDT effects upon irradiation with blue light, eradicating planktonic Staphylococcus aureus . Surprisingly however, no experiments were conducted on the combination of MHT with PDT using this nanoconjugate in this study [ 74 ]. These comparative studies of aPDT and MHT are listed in Table 5 .…”

Section: Combination With Magnetic Hyperthermia Therapymentioning

confidence: 99%

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

Songca

Adjei

2022

IJMS

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Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.

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“…[96] Curcumin has also been investigated to develop novel materials employed in various applications in chemical sensing (colorimetric sensor for copper, hemoglobin, and pH colored sensor), drug delivery applications as carrier, radical scavengers, environmental remediation, [97] and photosensitizers in dye-sensitized solar cells (DSSC) [98][99][100] and photodynamic therapy. [50,101] Despite the reported broad spectrum of promising properties, the practical use of curcumin especially in bio-applications has been hampered due to its disadvantageous physicochemical properties (extremely low solubility in aqueous media, instability), poor bioavailability, and rapid metabolism. As a result of this, in order to exploit the promising properties of curcumin for the health and novel functional materials, many strategies (derivatization, conjugation, polymerization, encapsulation, and nanotechnology) [50,51,102,103] Based on the above-mentioned objectives, we employed curcumin-loaded FSM aerogel as a model system for drug delivery and controlled release with possible applications in other areas reported for the curcumin.…”

Section: Curcumin Loaded Fsm Aerogel (Fag-cur)mentioning

confidence: 99%

“…Due to the unique properties of materials in the nanoscale regime (nanoscopic features, e.g., size dependent optoelectronic properties, electronic bandgap, and the magnetic susceptibility), nanomaterials have potential applications in numerous fields such as electronics, sensing, catalysis, energy, and biomedicine. [46][47][48][49][50][51][52] In recent decades, the intensively growing development of synthetic methods has made it possible to produce nanoparticles (NPs) with well-controlled and precisely tailored properties. The size, shape, and surface chemistry of colloidal nanocrystals can be controlled with almost atomic precision by controlling the synthetic methods and choosing the suitable synthesis conditions (e.g., temperature, concentration of the precursors/reactants, and proper choice of ligands).…”

Section: Introductionmentioning

confidence: 99%

Versatile Route for Multifunctional Aerogels Including Flaxseed Mucilage and Nanocrystals

Abdelmonem

Zámbó

Rusch

et al. 2022

Macromol. Rapid Commun.

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Preparation of low density monolithic and free-standing organic-inorganic hybrid aerogels of various properties is demonstrated using green chemistry from a biosafe natural source (flaxseed mucilage) and freeze-casting and subsequent freeze drying. Bio-aerogels, luminescent aerogels, and magneto-responsive aerogels are obtained by combination of the flaxseed mucilage with different types of nanoparticles. Moreover, the aerogels are investigated as possible drug release systems using curcumin as a model. Various characterization techniques like thermogravimetric analysis, nitrogen physisorption, electron microscopy, UV/Vis absorption, and emission spectroscopy, bulk density, and mechanical measurements, as well as in vitro release profile measurements, are employed to investigate the obtained materials. The flaxseed-inspired organic-inorganic hybrid aerogels exhibit ultra-low densities as low as 5.6 mg cm −3 for 0.5% (w/v) the mucilage polymer, a specific surface area of 4 to 20 m 2 g −1 , high oil absorption capacity (23 g g −1 ), and prominent compressibility. The natural biopolymer technique leads to low cost and biocompatible functional lightweight materials with tunable properties (physicochemical and mechanical) and significant potential for applications as supporting or stimuli responsive materials, carriers, reactors, microwave-and electromagnetic radiation protective (absorbing)-materials, as well as in drug delivery and oil absorption.

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Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy

Cited by 24 publications

References 64 publications

Superparamagnetic α-Fe2O3/Fe3O4 Heterogeneous Nanoparticles with Enhanced Biocompatibility

Superparamagnetic α-Fe2O3/Fe3O4 Heterogeneous Nanoparticles with Enhanced Biocompatibility

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

Versatile Route for Multifunctional Aerogels Including Flaxseed Mucilage and Nanocrystals

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