Conjugation of antimicrobial peptides to enhance therapeutic efficacy

Influence of Fatty Acid Modification on the Anticancer Activity of the Antimicrobial Peptide Figainin 1

“…The antimicrobial peptides secreted from the skins of amphibians have various functions, such as antibacterial and antitumor activities, but they still have disadvantages, such as poor stability. To improve the stability of these peptides, a variety of strategies have been reported in the literature, including stapling, cyclization, unnatural amino acid substitution, and fatty acid modification. , However, these strategies do not always work. Some modification strategies cannot improve the stability of the peptide, and some will lead to a decrease in the biological activity. , Therefore, it is necessary to screen modifications to the leading peptide.…”

“…To improve the stability of these peptides, a variety of strategies have been reported in the literature, including stapling, cyclization, unnatural amino acid substitution, and fatty acid modification. 28 , 29 However, these strategies do not always work. Some modification strategies cannot improve the stability of the peptide, and some will lead to a decrease in the biological activity.…”

Cationic Porphyrins as Antimicrobial and Antiviral Agents in Photodynamic Therapy

“…2023, 3, FOR PEER REVIEW Antimicrobial peptides (AMPs) are considered one of the most promising alternativ to antibiotics. AMPs, also called host-defense peptides, are part of the immune system bacteria, plants, and animals [146][147][148]. AMPs were studied against Gram-positive a Gram-negative bacteria, as well as fungi, parasites, and viruses [146].…”

Rejuvenation of Meropenem by Conjugation with Tilapia Piscidin-4 Peptide Targeting NDM-1 Escherichia coli

“…Among these strategies, conjugation with conventional antibiotics has become of special interest, as AMP-antibiotic hybrids often show enhanced efficacy against AMR pathogens concomitant with other desirable biological properties. 16 Conjugation of AMPs with antibiotics is a potential technique to leverage the advantages and overcome the limitations of individual component molecules. When two functional molecules are conjugated, a synergistic effect may occur, with the conjugate outperforming either individual constituent.…”

“…When two functional molecules are conjugated, a synergistic effect may occur, with the conjugate outperforming either individual constituent. 16 Therefore, the conjugation strategy is considered a useful means of rejuvenating or reutilizing antibiotics for AMR pathogens. 17,18 In this study, we chemically conjugated TP4 with the βlactam antibiotic Meropenem in an effort to overcome Meropenem resistance in pathogens.…”