Conjugation mediates large-scale chromosomal transfer inStreptomycesdriving diversification of antibiotic biosynthetic gene clusters
Caroline Choufa,
Pauline Gascht,
Hugo Leblond
et al.
Abstract:Streptomyces are ubiquitous soil dwelling bacteria of special importance as a source of metabolites used in human and veterinary medicine, agronomy and industry. Conjugation is the main mechanism of Streptomyces Horizontal Gene Transfer, and this process has long been known to be accompanied by mobilization of chromosomal DNA. However, the magnitude of DNA transfer, or the localization of acquired DNA across their linear chromosome, has remained undetermined. We here show that conjugative crossings in sympatri… Show more
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