Conjugation efficiency depends on intra and intercellular interactions between distinct plasmids: Plasmids promote the immigration of other plasmids but repress co-colonizing plasmids

Gama, João Alves; Zilhão, Rita; Dionísio, Francisco

doi:10.1016/j.plasmid.2017.08.003

Cited by 69 publications

(68 citation statements)

References 72 publications

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“…These mutations often influence replication and transmission rates, impacting plasmid dissemination in bacterial populations [34,135]. Importantly, epistatic interactions between plasmids and chromosomal loci or other MRE [89,133,[136][137][138] have been observed. Remarkably, these interactions include epistasis between plasmids and chromosomal resistance mutations [139], indicating that the acquisition of one resistance can favour or prevent the emergence of further resistance.…”

Section: Compensation Of the Fitness Costsmentioning

confidence: 99%

Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Durão

Balbontín

Gordo

2018

Trends in Microbiology

205

131

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Antibiotics target essential cellular functions but bacteria can become resistant by acquiring either exogenous resistance genes or chromosomal mutations. Resistance mutations typically occur in genes encoding essential functions; these mutations are therefore generally detrimental in the absence of drugs. However, bacteria can reduce this handicap by acquiring additional mutations, known as compensatory mutations. Genetic interactions (epistasis) either with the background or between resistances (in multiresistant bacteria) dramatically affect the fitness cost of antibiotic resistance and its compensation, therefore shaping dissemination of antibiotic resistance mutations. This Review summarizes current knowledge on the evolutionary mechanisms influencing maintenance of resistance mediated by chromosomal mutations, focusing on their fitness cost, compensatory evolution, epistasis, and the effect of the environment on these processes.

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Section: Compensation Of the Fitness Costsmentioning

confidence: 99%

Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Durão

Balbontín

Gordo

2018

Trends in Microbiology

205

131

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“…Interestingly, broad-host range RP4 had similar variation in transfer among hosts, and was no less sensitive to host control than R1, despite suggestions that IncF narrow host range might arise from their more complex regulation by host cells (de la Cruz et al, 2014). Finally, variation in transfer rates among natural isolates might even be higher than estimated here, as we selected isolates with no detected replicons, limiting the effect of modulation of transfer rates by co-resident plasmids (Gama et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Plasmid transfer is biased towards close kin in bacteria from natural populations

Dimitriu

Marchant

Buckling

et al. 2018

Preprint

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Plasmids play a key role in microbial ecology and evolution, yet the determinants of plasmid transfer rates are poorly understood. Here we investigate the importance of genetic similarity between naturally co-occurring Escherichia coli isolates in the transfer of two plasmids (narrow-host-range R1 and broad-host-range RP4). We uncovered extensive variability, spanning over five orders of magnitude, in the ability of isolates to donate and receive plasmids. Overall, transfer was strongly biased towards clone-mates, but not correlated to genetic distance between donors and recipients. Transfer was limited by the presence of a functional restriction-modification system in recipients, thus bias towards kin might be explained by sharing of identical restriction systems. Such conjugation within lineages sets the stage for longer-term pair-wise coevolutionary interactions between plasmids and bacterial hosts.

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“…The same may happen with two plasmids: one of them compensating for the cost of the other (San Millan, Heilbron, & MacLean, 2014; Silva et al, 2011). Furthermore, plasmids may interact with other plasmids in such a way as facilitating their transfer (Gama, Zilhao, & Dionisio, 2017a, 2017b). Finally, it has been suggested that most plasmids are perhaps costly if their fitness effect is measured within a short time of its isolation from nature (Gama et al, 2018; Lau, Malkus, & Paulsson, 2013).…”

Section: Discussionmentioning

confidence: 99%

The perfect condition for the rising of superbugs: person-to-person contagion and antibiotic use are the key factors responsible for the positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomes

Domingues

Rebelo

Nogueira

et al. 2020

Preprint

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this positive correlation emerges if the contagion probability between individuals is higher or, at least, not much lower than the loss rate of resistance genes. We argue that the loss rate may be very low, or even null, leaving contagion probability between people as the main factor. Moreover, antibiotic usage throughout tens of years selected resistance genes, which was key to establishing resistance genes diversity across human metagenomes, hence contributing to explain the positive correlation between antibiotic resistance gene diversity and virulence gene diversity.

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Conjugation efficiency depends on intra and intercellular interactions between distinct plasmids: Plasmids promote the immigration of other plasmids but repress co-colonizing plasmids

Cited by 69 publications

References 72 publications

Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Plasmid transfer is biased towards close kin in bacteria from natural populations

The perfect condition for the rising of superbugs: person-to-person contagion and antibiotic use are the key factors responsible for the positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomes

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