Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Ding, Dan; Li, Kai; Zhu, Zhenshu; Pu, Kanyi; Hu, Yong; Jiang, Xiqun; Liu, Bin

doi:10.1039/c0nr00950d

Cited by 103 publications

(91 citation statements)

References 49 publications

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“…The nanoprobes demonstrated near infra red fluorescent (NIRF) visualization of HepG2 cells in vitro, real time NIRF imaging in nude mice, and sustained release of cisplatin. 45 Porous silicon offers several attractive attributes for fabrication of theranostic scaffolds such as adjustable pore size and volume, simple chemical functionalization to incorporate drugs, large surface area and biocompatibility. Wu et al incorporated Daunorubicin into particles of porous Si photonic crystals through covalent conjugation.…”

Section: Theranostic Nanocarriers Providing Unimodal Imaging and Drugmentioning

confidence: 99%

The Upcoming Field of Theranostic Nanomedicine: An Overview

Prabhu

Patravale²

2012

Journal of Biomedical Nanotechnology

131

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Nanocarriers have drastically changed the face of health care by making a mark in diverse arenas of diagnosis, drug delivery, and gene delivery to name a few. The recent feat in nanotechnology has been the birth of nanotheranostics which aims at blending both therapeutic and diagnostic functions within a single nanoscaffold. The field of theranostic nanomedicine is a result of fruitful advances in fields of material science, imaging modalities, formulation development, and molecular biology. Theranostic nanomedicine that was at first developed for enhancing the quality of treatment meted out to cancer patients has now been explored even in atherosclerosis and infections, albeit to a lower extent. The review summarizes various types of nanocarriers that have been explored with one or sometimes multiple imaging modalities for an array of applications ranging from drug delivery and gene delivery to photosensitizing agent delivery for photodynamic therapy. The article also highlights the few but significant developments made in the field of theranostic nanomedicine for atherosclerosis and infections. In conclusion, theranostic nanomedicine is a rapidly growing field. However, there are a few problems that need to be addressed before theranostic nanocarriers carve a niche for themselves in the clinic.

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Section: Theranostic Nanocarriers Providing Unimodal Imaging and Drugmentioning

confidence: 99%

The Upcoming Field of Theranostic Nanomedicine: An Overview

Prabhu

Patravale²

2012

Journal of Biomedical Nanotechnology

131

View full text Add to dashboard Cite

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“…[ 126 ] Ding and co-workers reported a molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense PEG chains successfully complexed with cisplatin by forming cisplatinloaded nanoparticles (CPE-PEG-Pt). [ 127 ] The obtained nanoparticles had high far-red/near-infrared fl uorescence and were able to release the drug in a continuous and slow manner. It was also used to visualize HepG2 cancer cells as an in vivo fl uorescent imaging probe that simultaneously tracked the drug distribution in nude mice upon intravenous administration.…”

Section: Drug Deliverymentioning

confidence: 99%

New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide

2012

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Graphene, a one-atom-thick two-dimensional (2D) layer of sp(2) -bonded carbon, has received worldwide attention owing to its extraordinary physical and chemical properties. Recently, great efforts have been devoted to explore potential applications of graphene and its oxide in life science, especially in disease-related diagnostics, near-Infrared (NIR) phototherapy and imaging. Here we will introduce recent advances and new horizons in this area, and focus on the rising progress on NIR photothermal therapy for cancer and Alzheimer's disease (AD), human telomerase detection, stem cell proliferation and differentiation on graphene substrate, diagnosis of cancer cell and related biomarkers, drug/nucleotide/peptide delivery and cell imaging, which have not been comprehensively reviewed. We hope to provide an outlook to the applications of graphene and its oxide, especially on the new horizons in this field, and inspire broader interests across various disciplines.

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“…Hence, CPEs can be used in biosensing, drug and gene delivery, drug screening, and antimicrobial and anticancer therapies [17][18][19][20]. They have also been studied for their potential use in detection and sensing as well as for fluorescence imaging in vitro and in vivo [21][22][23].…”

Section: Introductionmentioning

confidence: 98%

Nanoparticles of Conjugated Molecules and Polymers for Biomedical Applications

Seo

Lee

Cho

et al. 2015

Advances in Polymer Science

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Semiconducting organic materials based on π-conjugated molecules or polymers have recently received considerable attention for their use as imaging and therapeutic agents for biomedical applications. Because π-conjugated materials exhibit desirable characteristics such as high brightness, photostability, emission tunability, and low toxicity, they are an attractive alternative to conventional fluorophores. In this review, the recent development of π-conjugated molecular nanoparticles for in vitro and in vivo biomedical applications is discussed.

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Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Cited by 103 publications

References 49 publications

The Upcoming Field of Theranostic Nanomedicine: An Overview

The Upcoming Field of Theranostic Nanomedicine: An Overview

New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide

Nanoparticles of Conjugated Molecules and Polymers for Biomedical Applications

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