Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide–Induced Model of Demyelination

Barzegarzadeh, Behnaz; Hatami, H.; Dehghan, Gholamreza; Khajehnasiri, Nazli; Khoobi, Mehdi; Sadeghian, Reihaneh

doi:10.1007/s12640-020-00310-0

Cited by 14 publications

(9 citation statements)

References 37 publications

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“…Each rat was put into the pool facing the sidewall at the start of each test. The pool area is divided into four quadrants based on four points arbitrarily designated as North, South, East, or West around the circle of the pool [ 30 , 31 , 32 ]. The rats were allowed to swim until they got to the platform and stayed there for 20 s. The experimenter guided the animals to the platform if they had not found it after 60 s and allowed them to stay on it for 20 s [ 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

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Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

Roshani

Hatami²,

Sadeghian³

et al. 2022

Heliyon

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Section: Methodsmentioning

confidence: 99%

“…Sixty seconds of swimming were allowed on the fifth day after removing the platform. On the last day, groups were compared based on time spent in the target quadrant [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

Roshani

Hatami²,

Sadeghian³

et al. 2022

Heliyon

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“…In a recent article [ 108 ], a synthetic derivative of curcumin (CUR) and linoleic acid (Lino) was synthesized, in order to test the activity of the combined structure, in comparison to curcumin alone, on spatial memory and oxidative stress, induced by intracerebroventricular administration of ethidium bromide. The synthesis of the derivative (Lino-CUR) ( Figure 7 ) was performed from Lino and Cur, in the presence of dimethylaminopyridine and 1-ethyl-3-(3-dimethylaminopropyl carbodiimide), at equimolar quantities, in acetone, overnight, and purification of resulted crude material with flash column silica chromatography.…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

The Multiple Sclerosis Modulatory Potential of Natural Multi-Targeting Antioxidants

Theodosis-Nobelos

Rekka

2022

Molecules

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Multiple sclerosis (MS) is a complex neurodegenerative disease. Although its pathogenesis is rather vague in some aspects, it is well known to be an inflammatory process characterized by inflammatory cytokine release and oxidative burden, resulting in demyelination and reduced remyelination and axonal survival together with microglial activation. Antioxidant compounds are gaining interest towards the manipulation of MS, since they offer, in most of the cases, many benefits, due to their pleiotropical activity, that mainly derives from the oxidative stress decrease. This review analyzes research articles, of the last decade, which describe biological in vitro, in vivo and clinical evaluation of various categories of the most therapeutically applied natural antioxidant compounds, and some of their derivatives, with anti-MS activity. It also summarizes some of the main characteristics of MS and the role the reactive oxygen and nitrogen species may have in its progression, as well as their relation with the other mechanistic aspects of the disease, in order for the multi-targeting potential of those antioxidants to be defined and the source of origination of such activity explained. Antioxidant compounds with specific characteristics are expected to affect positively some aspects of the disease, and their potential may render them as effective candidates for neurological impairment reduction in combination with the MS treatment regimen. However, more studies are needed in order such antioxidants to be established as recommended treatment to MS patients.

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“…También se le atribuye un efecto preventivo contra el daño neuronal asociado con la edad (64)(65)(66) . Cabe mencionar que el ácido linoleico pertenece a los PUFA que tienen efecto antioxidante y son efectivos en las enfermedades neurodegenerativas, como la EA, la EP, la enfermedad de Huntington, las enfermedades de la retina e incluso en la esclerosis múltiple (EM), cuando se valoran sus efectos en combinación con la curcumina, sustancia activa de la cúrcuma, que es un antioxidante natural con acción antiinflamatoria (67,68) .…”

Section: Efectos Biológicos Y Nutricionales Del áCido Linoleico Conju...unclassified

Neuronutrición: repercusiones de los excesos y de las deficiencias nutricionales

López-Hernández

2022

rncm

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La neuronutrición es la ciencia que estudia el efecto de los nutrientes en el sistema nervioso y sus funciones. Esta área investiga la relación directa que existe entre los nutrimentos y la producción de los neuromoduladores, los cuales desempeñan un papel primordial en la regulación de muchos aspectos de la actividad cerebral, como el humor, la motivación, el estrés, los comportamientos alimentarios (hambre y saciedad), el sueño y toda la parte emocional que interviene en la alimentación.

show abstract

Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide–Induced Model of Demyelination

Cited by 14 publications

References 37 publications

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

The Multiple Sclerosis Modulatory Potential of Natural Multi-Targeting Antioxidants

Neuronutrición: repercusiones de los excesos y de las deficiencias nutricionales

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