Conjugated estrogens as adjuvant therapy in the treatment of acute schizophrenia: a double-blind study

Louzã, Mário Rodrigues; Marques, Ana Paula; Elkis, Hélio; Bassitt, Débora Pastore; Diêgoli, Mara Solange Carvalho; Gattaz, Wagner F.

doi:10.1016/s0920-9964(03)00082-3

Cited by 49 publications

(23 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Louza et al 2004 [48] did not find a positive response to estrogen treatment in their study, which they correctly discussed as possibly being due to having used conjugated estrogens rather than 17-ß-estradiol. In a Cochrane review in 2005, Chua et al [49] surveyed data from only five randomised double blind intervention studies with appropriate methodology.…”

Section: Intervention Studiesmentioning

confidence: 83%

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Riecher-Rössler¹,

Kulkarni

2010

Biological Basis of Sex Differences in Psychopharmacology

View full text Add to dashboard Cite

Section: Intervention Studiesmentioning

confidence: 83%

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Riecher-Rössler¹,

Kulkarni

2010

Biological Basis of Sex Differences in Psychopharmacology

View full text Add to dashboard Cite

“…Six studies applied the estrogen (ethinyl)estradiol, and 1 study administered estrone. 63 Estrogen doses ranged from 0.05 mg/d (patch) to 2 mg/d (orally). One of the studies restricted inclusion to FEP.…”

Section: Estrogensmentioning

confidence: 99%

Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update

Sommer

Westrhenen

Begemann

et al. 2013

Schizophrenia Bulletin

302

232

View full text Add to dashboard Cite

show abstract

“…An alternative explanation for the lack of a significant relationship is that the observed estrogenic effects are not directly related to estradiol but another estrogen, such as estrone. Indeed, Louzā et al (2004) reported that schizophrenic patients given an adjunctive estrone treatment showed a trend towards greater symptom improvement than patients given an adjunctive placebo. The authors note, however, that this effect was not comparable to the significant improvements seen in patients with 17β-estradiol (e.g.…”

Section: The Relationship Between Sex Hormones Schizotypy and Memorymentioning

confidence: 99%

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Hodgetts

Hausmann

Weis

2015

Psychiatry Research

View full text Add to dashboard Cite

(2015) 'High estradiol levels improve false memory rates and meta-memory in highly schizotypal women.', Psychiatry research., 229 (3). pp. 708-714. Further information on publisher's website:https://doi.org/10.1016/j.psychres. 2015.08.016 Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractOverconfidence in false memories is often found in patients with schizophrenia and healthy participants with high levels of schizotypy, indicating an impairment of meta-cognition within the memory domain. In general, cognitive control is suggested to be modulated by natural fluctuations in estrogen. However, whether estrogen exerts beneficial effects on metamemory has not yet been investigated. The present study sought to provide evidence that high levels of schizotypy are associated with increased false memory rates and overconfidence in false memories, and that these processes may be modulated by natural differences in estradiol levels. Using the Deese-Roediger-McDermott paradigm, it was found that highly schizotypal participants with high estradiol produced significantly fewer false memories than those with low estradiol. No such difference was found within the low schizotypy participants. Highly schizotypal participants with high estradiol were also less confident in their false memories than those with low estradiol; low schizotypy participants with high estradiol were more confident. However, these differences only approached significance. These findings suggest that the beneficial effect of estradiol on memory and meta-memory observed in healthy participants is specific to highly schizotypal individuals and might be related to individual differences in baseline dopaminergic activity.

show abstract

Conjugated estrogens as adjuvant therapy in the treatment of acute schizophrenia: a double-blind study

Cited by 49 publications

References 12 publications

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Contact Info

Product

Resources

About