Conjugated equine estrogens and estradiol benzoate differentially modulate the natriuretic peptide system in spontaneously hypertensive rats

Firmes, Luciana Barbosa; Belo, Najara O.; Reis, Adelina Martha dos

doi:10.1097/gme.0b013e318276c4cc

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…A two-way ANOVA of blood pressure levels revealed a main effect of strain (p < 0.0001) and steroid treatment (p < 0.01). However, the hypotensive effects of 17␤-estradiol may be explained only in part by down-regulation of AVP [69], because Firmes et al [83] recently reported that the decrease of blood pressure of SHR by 17␤-estradiol was associated to changes of several components of the natriuretic peptide system. In summary, hypertension under ovarian steroid deprivation could be due to several contributing factors [84], whereas estrogen-induced decrease of blood pressure may also involve several central and peripheral mediators.…”

Section: Effects Of 17␤-estradiol On Hypothalamic Arginine-vasopressi...mentioning

confidence: 99%

Estrogens are neuroprotective factors for hypertensive encephalopathy

Pietranera

Brocca

Roig

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Effects Of 17␤-estradiol On Hypothalamic Arginine-vasopressi...mentioning

confidence: 99%

Estrogens are neuroprotective factors for hypertensive encephalopathy

Pietranera

Brocca

Roig

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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“…The influence of estrogens on the production and secretion of NPs has been well established in humans (5), rats (6) and mice (7). Estrogens act by stimulating the production and secretion of NPs; the levels of estrogen are low in ovariectomized (OVX) rats and mice (8) but are restored by 17β-estradiol administration (9-16).…”

Section: Introductionmentioning

confidence: 99%

Effects of ovariectomy on the secretory apparatus in the right atrial cardiomyocytes of middle-aged mice

Souza

Oliveira

Curi

et al. 2014

Clinics

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OBJECTIVE: The aim of the present study was to evaluate the effects of ovariectomy on the secretory apparatus of natriuretic peptides in right atrial cardiomyocytes.METHODS:Nine-month-old mice underwent bilateral ovariectomy or sham surgery. The blood exam of the ovariectomized mice showed results consistent with castrated females. Systolic blood pressure was measured after ovariectomy (9 mo of age) and at the moment of sacrifice (12 mo of age). Fragments of the right atrium were collected and prepared for electron microscopy examination. The following variables were quantified: the quantitative density and area of the natriuretic peptide granules, the relative volume of euchromatin in the nucleus, the number of pores per 10 μm of the nuclear membrane and the relative volumes of the mitochondria and Golgi complex.RESULTS:The cardiomyocytes obtained from ovariectomized mice indicated that the quantitative density and the area of secretory granules of natriuretic peptides were significantly lower compared with the sham-operated mice. Furthermore, there was a decrease in the relative volume of euchromatin, a lower density of nuclear pores, and lower relative volumes of the mitochondria and Golgi complex in the ovariectomized mice compared with the sham-operated mice. These findings suggest a pool with a low turnover rate, i.e., low synthesis and elimination of natriuretic peptides.CONCLUSION:A lack of estrogen caused hypotrophy of the secretory apparatus in right atrial cardiomyocytes that could explain the weak synthesis of natriuretic peptides in mice. Furthermore, one of the mechanisms of blood pressure control was lost, which may explain, in part, the elevated blood pressure in ovariectomized mice.

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