1997
DOI: 10.1080/07328319708006147
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Conjugated Antisense Oligonucleotides

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Cited by 20 publications
(18 citation statements)
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“…The uptake, and antisense activity of these ONAs are indeed greatly improved compared to underivatized analogs. 86,[95][96][97] Additionally and not surprisingly, such lipophilic conjugates proved to be more resistant toward nucleases, 94,95,98 and the resistance increases with the size of the aliphatic chain. 99 This strategy proved also successful with si-RNAs.…”
Section: Onas As Antisensementioning
confidence: 97%
“…The uptake, and antisense activity of these ONAs are indeed greatly improved compared to underivatized analogs. 86,[95][96][97] Additionally and not surprisingly, such lipophilic conjugates proved to be more resistant toward nucleases, 94,95,98 and the resistance increases with the size of the aliphatic chain. 99 This strategy proved also successful with si-RNAs.…”
Section: Onas As Antisensementioning
confidence: 97%
“…The former property is useful in the field of chip technology and diagnostics. [7][8][9][10] As an alternative, nucleosides in which the lipophilic group is attached to the nucleobase could also be incorporated into any position of an oligonucleotide. [2,3] The ability of oligonucleotides to permeate cell membranes by the introduction of lipidic structures into the oligonucleotides has been used in the development of antiviral compounds.…”
Section: Introductionmentioning
confidence: 99%
“…In animal models, the P=S ODNs have a clear margin of safety, which has been borne out in clinical trials where systemic administration by intravenous infusion has been well tolerated. Formulation and/or chemical modification of antisense oligonucleotides can alter the pharmacokinetics and distribution (1,5,8,28 …”
Section: Future Directions Of Antisense Therapeuticsmentioning
confidence: 99%