Conjugated and unconjugated oestrogens in fetal and maternal fluids of the cow throughout pregnancy

Robertson, H. A.; King, G. J.

doi:10.1530/jrf.0.0550463

Cited by 114 publications

(49 citation statements)

References 12 publications

(18 reference statements)

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“…The sensitivity of these assay systems was approximately 30 pg/mL and the results were consistent. It was reported that the estrone sulfate concentration in bovine milk during gestation was lower than the detectable level in the first 80 to 90-day period and showed a sharp rise after day 100, which was consistent with the plasma concentration of estrone sulfate at the same gestational stage 1,10,15 . Based on the results of these reports and the present experiment, estrone sulfate can be detected in bovine milk before day 100.…”

Section: Discussionsupporting

confidence: 78%

“…and milk increase gradually throughout gestation in the same way as those of free estrogens, and its level at each stage of gestation is the highest among all the estrogens, especially during the mid-to late periods of gestation 7,9,15 . Therefore, it is considered to be a practical indicator of placental function and has been used in pregnancy diagnosis 9,10 and in predicting the number of fetuses 1,17,20 .…”

Section: Jarq 37 (3) 2003mentioning

confidence: 92%

“…The concentrations of estrone and estradiol-17β in bovine blood plasma remain low during the early period of gestation and increase gradually throughout mid-to late gestation 10,14,15 . Estrone sulfate is a sulfo-conjugate of estrogen and is mainly derived from the conceptus during gestation in cattle 13 .…”

Section: Introductionmentioning

confidence: 99%

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Changes in Plasma Estrogen Concentrations during the First Trimester of Gestation in Dairy Cows: Comparison with the Origin of Embryos and Fetal Number

Hirako

Takahashi

et al. 2003

JARQ

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The objectives of this study were to determine the profiles of plasma estrogen concentrations during the first trimester of gestation and to correlate them with the origin of the embryos and fetal number. Pregnancies were induced either by artificial insemination (AI) on the day of estrus (day 0) or by transfer of 1 or 2 blastocysts produced in vitro (IVF-ET) on day 7. Five singleton-bearing cows impregnated by AI, and 6 singleton and 6 twin pregnancies induced by IVF-ET were used in the experiment. Blood was collected by jugular venipuncture at 2 to 5-day intervals until day 100. The concentrations of plasma estrone, estradiol-17β and estrone sulfate were measured by using a radioimmunoassay. Concentrations of all the estrogens fluctuated at low levels until day 50 in all the groups. Thereafter, the concentration of estrone sulfate gradually increased, whereas those of estrone and estradiol-17β remained at basal levels until day 80. The concentration of estrone sulfate after day 50 was affected by the day of gestation and the number of fetuses. After day 80, the concentration of estrone sulfate increased drastically, coinciding with the increases in the estrone and estradiol-17β concentrations. The rate of increase in the concentration of estrone sulfate during days 80 to 100 was the highest among all the estrogens. In the singleton pregnancies, the concentrations of estrone and estrone sulfate between days 80 and 100 were higher in the artificially inseminated cows than in the IVF-ET cows. In the pregnancies induced by IVF-ET, estrone sulfate levels were higher in the twin-bearing cows than in the singleton-bearing cows during days 50 to 80 and 80 to 100. These results suggest that the concentrations of estrogens in bovine peripheral blood plasma could be applied for monitoring fetoplacental development in the first trimester of gestation.Discipline: Animal industry Additional key words: estradiol-17β, estrone, estrone sulfate, in vitro fertilization and multiple pregnancies JARQ 37 (3), 195 -200 (2003) http://www.jircas.affrc.go.jp Present address:

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Section: Discussionsupporting

confidence: 78%

Section: Jarq 37 (3) 2003mentioning

confidence: 92%

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Changes in Plasma Estrogen Concentrations during the First Trimester of Gestation in Dairy Cows: Comparison with the Origin of Embryos and Fetal Number

Hirako

Takahashi

et al. 2003

JARQ

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“…3) (Melampy et al, 1959) although some authors (MacDonald, McNutt & Nichols, 1953;Zimbelman, Loy & Casida, 1961;Ainsworth & Ryan, 1967) claim that negligible amounts of progestagens are synthesized by the bovine placenta. The corpus luteum of pregnancy produces large amounts of progesterone throughout the whole of pregnancy but a contribution by the placenta or the adrenals (Wendorf, Lawyer & First, 1983) Kamonpatana (1984); and for cows after Dobson & Dean (1974), Robertson (1974), Robertson & King (1979), Thatcher et al (1980) and Kaker et al (1984).…”

Section: Pubertymentioning

confidence: 99%

A review of female cattle reproduction with special reference to a comparison between buffaloes, cows and zebu

Dobson¹,

Kamonpatana²

1986

Reproduction

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“…The fetal or cotyledonary portions of the bovine placentome are major sites of the synthesis and conjugation of estrogens during pregnancy [14]. Conversion between E1 and E1S and their concentrations in maternal plasma are controlled by enzymes, estrogen sulfotransferase and steroid sulfatase, located in the placentome [15].…”

mentioning

confidence: 99%

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

et al. 2007

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Abstract. The aim of this study was to evaluate the changes in plasma concentrations of estrone sulfate (E1S) and estradiol-17β (E2β) during the peripartum period (from day 10 prepartum to day 1 postpartum) associated with and without retention of fetal membranes (RFM) in Holstein-Friesian cattle (n=42). Plasma samples were analyzed for E1S and E2β by ELISA. All parturitions were spontaneous and normal. Of 38 cattle delivering singletons, 29 had no RFM (singleton-normal group) and nine had RFM for more than 12 h (singleton-RFM group). Four cows gave birth to twins, and each twin had its own fetal membrane (FM). Two twinning cows expelled both FMs normally within 12 h (twin-normal group). In the remaining 2 twinning cows (twin-RFM group), the FM was expelled normally for one twin (first), while the FM of the other (second) was retained. There were no significant differences in the E1S concentrations or their increments from the concentrations on the preceding day between the normal and RFM groups of singleton cows on any peripartum day. The mean plasma E2β concentrations on each day from day 10 to day 3 prepartum were significantly lower (P<0.05) in the singleton-RFM group compared with the singleton-normal group; however, on days 2 and 1 prepartum, the increments in the E2β concentrations from the concentrations on the preceding days were significantly higher (P<0.05) in the singleton-RFM group than in the singleton-normal group. Thus, the plasma E1S concentrations just before parturition may not be associated with RFM. In the cows with RFM, the lower plasma E2β concentrations that were found prior to day 2 prepartum may have been associated with immature placentomes, and the rapid rise in plasma E2β within 1 to 2 days prior to calving may have produced asynchrony of placental and/or fetal maturation in relation to calving, thus resulting in RFM.

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Conjugated and unconjugated oestrogens in fetal and maternal fluids of the cow throughout pregnancy

Abstract: Summary. The changes in concentration of oestrone, oestradiol (-17\g=a\ and -17\g=b\

Cited by 114 publications

References 12 publications

Changes in Plasma Estrogen Concentrations during the First Trimester of Gestation in Dairy Cows: Comparison with the Origin of Embryos and Fetal Number

Changes in Plasma Estrogen Concentrations during the First Trimester of Gestation in Dairy Cows: Comparison with the Origin of Embryos and Fetal Number

A review of female cattle reproduction with special reference to a comparison between buffaloes, cows and zebu

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

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