Conjugate Vaccine Production Technology

Chennasamudram, Sudha; Vann, Willie F.

doi:10.1002/9781118870914.ch7

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…For existing products, glycoconjugate construction has been an empirically driven process of linking two molecules (carbohydrate and protein) without considering the molecular and cellular immune mechanisms critical for conjugate vaccine efficacy. A deeper understanding of these mechanisms (e.g., antigen uptake, processing, and T-cell activation) may also provide opportunities for optimizing novel chemical or biological conjugation technologies that have been recently described (18–20). Thus, delineating T-cell-mediated immune activation pathways by glycoconjugate vaccines has important implications for using these vaccines to control or eliminate infectious diseases globally.…”

Section: Product Characteristics That Influence Immune Responsementioning

confidence: 99%

“…Quality attributes such as saccharide size, degree of saccharide activation, constraints on modifications of saccharide structure, use of linkers, density of attachment on carrier protein, or size distribution of conjugate particles appear important to control. New platforms (18–20) that allow the more precise control of such parameters should be used to develop test molecules for use in in vitro , in vivo , and ex vivo models to explore mechanisms of immune response to glycoconjugate vaccines. We do not know whether the Tcarb clone repertoire is dependent on the conjugation platform.…”

Section: Product Characteristics That Influence Immune Responsementioning

confidence: 99%

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Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

Avci

Dull

Hennessey

et al. 2019

mSphere

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Section: Product Characteristics That Influence Immune Responsementioning

confidence: 99%

Section: Product Characteristics That Influence Immune Responsementioning

confidence: 99%

Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

Avci

Dull

Hennessey

et al. 2019

mSphere

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An Overview of Structural Features of Antibacterial Glycoconjugate Vaccines That Influence Their Immunogenicity

Khatun

Stephenson

Tóth

2017

Chemistry A European J

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Bacterial cell-surface-derived or mimicked carbohydrate moieties that act as protective antigens are used in the development of antibacterial glycoconjugate vaccines. The carbohydrate antigen must have a minimum length or size to maintain the conformational structure of the antigenic epitope(s). The presence or absence of O-acetate, phosphate, glycerol phosphate and pyruvate ketal plays a vital role in defining the immunogenicity of the carbohydrate antigen. The nature of the carrier protein, spacer and conjugation pattern used to develop the glycoconjugate vaccine also defines its overall spatial orientation which in turn affects its avidity and selectivity of interaction with the desired target(s). In addition, the ratio of carbohydrate to protein in glycoconjugate vaccines also makes an important contribution in determining the optimum immunological response. This Review article presents the importance of these variables in the development of antibacterial glycoconjugate vaccines and their effects on immune efficacy.

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On the mechanisms of conjugate vaccines

Rappuoli

Gregorio

Costantino³

2018

Proc. Natl. Acad. Sci. U.S.A.

111

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During the last three decades, the development and commercialization of conjugate vaccines against Haemophilus influenzae type b (Hib), pneumococcus, and serogroups C, A, W, and Y of meningococcus contributed to the virtual elimination of bacterial meningitis caused by the bacteria included in the vaccines and to the prevention of diseases that used to cause more than a million deaths annually (1, 2). Despite the great impact on public health of these vaccines, our understanding of the way these vaccines work is still limited, and we have many unanswered questions. In PNAS, Sun et al. (3) report new mechanistic insights on conjugate vaccines.

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Conjugate Vaccine Production Technology

Cited by 3 publications

References 67 publications

Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

An Overview of Structural Features of Antibacterial Glycoconjugate Vaccines That Influence Their Immunogenicity

On the mechanisms of conjugate vaccines

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