Conjugal and familial Lewy body disorders: A report of one family

Ramani, Manish; Saur, David P.; Rabin, Marcie L.; Kurlan, Roger

doi:10.1016/j.parkreldis.2013.01.004

Cited by 2 publications

(6 citation statements)

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“…Previously there have been reports of conjugal PD in 9 married couples, 33 conjugal MSA in 1 couple, conjugal PD and MSA in 1 couple, 18 and conjugal PD and DLB in 1 couple. 19 Although there were several couples with both spouses having either ILBD or ADLB, the overall prevalence of ILBD and ADLB is high in elderly autopsy series, and therefore chance occurrence is the most likely explanation. The prevalence of ILBD in the current study was 19 of 109 (17.4%), very similar to that in our AZSAND cohort as a whole, 13.4%.…”

Section: Discussionmentioning

confidence: 99%

“…The finding of 16 conjugal couples with synucleinopathies (17.8% of the 90 couples that were autopsied; 28% of the 58 couples had at least 1 spouse with a synucleinopathy), especially with only 5 having both spouses with PD and/or DLB, is not a very compelling case for transmission of synucleinopathy between spouses. Previously there have been reports of conjugal PD in 9 married couples, 33 conjugal MSA in 1 couple, conjugal PD and MSA in 1 couple, 18 and conjugal PD and DLB in 1 couple 19 …”

Section: Discussionmentioning

confidence: 99%

“…Studies have indicated that occupational exposure to environmental factors, such as pesticides and heavy metals, increases the risk of parkinsonian disorders 18‐20,33,38‐40 . One study found that lifelong pesticide use was associated with an increased risk of PD 39 .…”

Section: Discussionmentioning

confidence: 99%

“…It is known that the prion disease CJD has been found in spouses or individuals who had close social contact with families with CJD 12‐16 . There have a been few reports of conjugal cases of PD or MSA (mainly without autopsy confirmation) in the past two decades, with no reports of conjugal DLB 10,11,17‐22 . It remains unclear if shared environmental exposure, transmission, or chance results in conjugal synucleinopathies 20‐23 .…”

mentioning

confidence: 99%

“…[12][13][14][15][16] There have a been few reports of conjugal cases of PD or MSA (mainly without autopsy confirmation) in the past two decades, with no reports of conjugal DLB. 10,11,[17][18][19][20][21][22] It remains unclear if shared environmental exposure, transmission, or chance results in conjugal synucleinopathies. [20][21][22][23] To our knowledge no large-scale systematic autopsy studies have investigated conjugal synucleinopathies.…”

mentioning

confidence: 99%

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Conjugal Synucleinopathies: A Clinicopathologic Study

Adler,

Halverson,

Zhang

et al. 2024

Movement Disorders

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BackgroundWhile preclinical studies have shown that alpha‐synuclein can spread through cell‐to‐cell transmission whether it can be transmitted between humans is unknown.ObjectivesThe aim was to assess the presence of a synucleinopathy in autopsied conjugal couples.MethodsNeuropathological findings in conjugal couples were categorized as Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease with Lewy bodies (ADLB), incidental Lewy body disease (ILBD), or no Lewy bodies.ResultsNinety conjugal couples were included; the mean age of death was 88.3 years; 32 couples had no Lewy bodies; 42 couples had 1 spouse with a synucleinopathy: 10 PD, 3 DLB, 13 ADLB, and 16 ILBD; 16 couples had both spouses with a synucleinopathy: in 4 couples both spouses had PD, 1 couple had PD and DLB, 4 couples had PD and ADLB, 2 couples had PD and ILBD, 1 couple had DLB and ADLB, in 3 couples both had ADLB, and 1 couple had ADLB and ILBD. No couples had both spouses with ILBD.ConclusionsThis large series of 90 autopsied conjugal couples found 16 conjugal couples with synucleinopathies, suggesting transmission of synucleinopathy between spouses is unlikely. © 2024 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 99%