Conjoint Analysis Applications in Health—a Checklist: A Report of the ISPOR Good Research Practices for Conjoint Analysis Task Force

Bridges, John F.P.; Hauber, A. Brett; Marshall, Deborah A.; Lloyd, Andrew; Prosser, Lisa A.; Regier, Dean A.; Johnson, F. Reed; Mauskopf, Josephine

doi:10.1016/j.jval.2010.11.013

Cited by 1,493 publications

(1,723 citation statements)

References 49 publications

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“…Study design and analysis followed current guidelines for conducting DCEs. 13,19,20 study sample Pregnant women were recruited from the obstetric ultrasound department London Hospital and three at regional NHS hospitals. This group was a convenience sample of Englishspeaking women who were attending for a second-or thirdtrimester ultrasound scan.…”

Section: Methodsmentioning

confidence: 99%

Women’s and health professionals’ preferences for prenatal tests for Down syndrome: a discrete choice experiment to contrast noninvasive prenatal diagnosis with current invasive tests

Hill

Fisher²,

Chitty

et al. 2012

Genetics in Medicine

117

137

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Original research articlePurpose: To compare the preferences of women and health professionals for key attributes of noninvasive prenatal diagnosis for Down syndrome relative to current invasive tests. methods:A questionnaire incorporating a discrete choice experiment was used to obtain participants' stated preference for diagnostic tests that varied according to four attributes: accuracy, time of test, risk of miscarriage, and provision of information about Down syndrome only or Down syndrome and other conditions. Women and health professionals were recruited from five maternity services in England and a patient support group. Results:Questionnaires from 335 women and 181 health professionals were analyzed. Safe tests, conducted early in pregnancy, with high accuracy and information about Down syndrome and other conditions were preferred. The key attribute affecting women's preferences for testing was no risk of miscarriage, whereas for health professionals it was accuracy.conclusions: Policies for implementing noninvasive prenatal diagnosis must consider the differences between women's and health professionals' preferences to ensure the needs of all stakeholders are met. Women's strong preference for tests with no risk of miscarriage demonstrates that consideration for safety of the fetus is paramount in decision making. Effective pretest counseling is therefore essential to ensure women understand the possible implications of results. 2012:14(11):905-913 Genet Med

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Section: Methodsmentioning

confidence: 99%

Women’s and health professionals’ preferences for prenatal tests for Down syndrome: a discrete choice experiment to contrast noninvasive prenatal diagnosis with current invasive tests

Hill

Fisher²,

Chitty

et al. 2012

Genetics in Medicine

117

137

View full text Add to dashboard Cite

show abstract

“…Therefore, we would recommend that prior discussion take place on the nature of the question(s) to be asked, as often happens before major referendums. Surveys should employ methods, such as conjoint analysis [11], that explicitly explore the trade-offs between the various attributes of therapies including their differential cost. Also, it might be worthwhile exploring use of the person trade-off method, first proposed by Nord [12].…”

Section: Clarifying Society's Valuesmentioning

confidence: 99%

Orphan drugs policies: a suitable case for treatment

Drummond

Towse

2014

Eur J Health Econ

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Context Current orphan drug policies are unsatisfactory when viewed from almost all perspectives. Patients find that, although therapies are available for many rare conditions, access to care is sometimes restricted. Pharmaceutical manufacturers have responded to the incentives for research embodied in orphan drug legislation, only to find that funds are not made available to pay for therapies once developed. Those funding health care find that most orphan drugs do not justify funding based on standard value for money criteria, yet that they face political problems if they fail to provide funding for therapy. Methods A literature review was conducted in order to determine the precise nature of the problems and to suggest potential solutions. Results Current orphan drug policies are not fit for the purpose and initiatives need to be taken in the areas of (1) clarifying society's views about the priority to be given to orphan drugs, (2) revising the arrangements for pricing and reimbursement of orphan drugs, (3) defining the priorities for research into rare diseases and (4) developing 'joined up' policies to deal with these issues. Conclusions Without changes in the current policies, pharmaceutical companies will eventually cease responding to the incentives to develop orphan drugs, because they will increasingly be uncertain whether the drugs, if developed, will be reimbursed.

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“…ACBC analysis is a form of tradeoff analysis that elucidates how people make complex decisions by balancing competing factors (26,27). Respondents evaluate competing profiles (e.g., of a product or patient) and select the preferred profile.…”

Section: Overview Of Acbc Analysismentioning

confidence: 99%

“…A task force from the International Society for Pharmacoeconomic and Outcomes Research developed guidelines for the use of conjoint analysis in analyzing clinical decisions (26) that were used in developing this survey. Conjoint analysis has been used in evaluating clinical decision-making in depression (31), rheumatology (32), spinal surgery (33), diabetes management (34), and interhospital transport of critically ill patients (35,36).…”

Section: Overview Of Acbc Analysismentioning

confidence: 99%

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Clinical Factors and the Decision to Transfuse Chronic Dialysis Patients

Whitman

Shreay

Gitlin

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Red blood cell transfusion was previously the principle therapy for anemia in CKD but became less prevalent after the introduction of erythropoiesis-stimulating agents. This study used adaptive choice-based conjoint analysis to identify preferences and predictors of transfusion decision-making in CKD.Design, setting, participants, & measurements A computerized adaptive choice-based conjoint survey was administered between June and August of 2012 to nephrologists, internists, and hospitalists listed in the American Medical Association Masterfile. The survey quantified the relative importance of 10 patient attributes, including hemoglobin levels, age, occult blood in stool, severity of illness, eligibility for transplant, iron indices, erythropoiesis-stimulating agents, cardiovascular disease, and functional status. Triggers of transfusions in common dialysis scenarios were studied, and based on adaptive choice-based conjoint-derived preferences, relative importance by performing multivariable regression to identify predictors of transfusion preferences was assessed.Results A total of 350 providers completed the survey (n=305 nephrologists; mean age=46 years; 21% women). Of 10 attributes assessed, absolute hemoglobin level was the most important driver of transfusions, accounting for 29% of decision-making, followed by functional status (16%) and cardiovascular comorbidities (12%); 92% of providers transfused when hemoglobin was 7.5 g/dl, independent of other factors. In multivariable regression, Veterans Administration providers were more likely to transfuse at 8.0 g/dl (odds ratio, 5.9; 95% confidence interval, 1.9 to 18.4). Although transplant eligibility explained only 5% of decision-making, nephrologists were five times more likely to value it as important compared with non-nephrologists (odds ratio, 5.2; 95% confidence interval, 2.4 to11.1).Conclusions Adaptive choice-based conjoint analysis was useful in predicting influences on transfusion decisions. Hemoglobin level, functional status, and cardiovascular comorbidities most strongly influenced transfusion decision-making, but preference variations were observed among subgroups.

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Conjoint Analysis Applications in Health—a Checklist: A Report of the ISPOR Good Research Practices for Conjoint Analysis Task Force

Abstract: Although the checklist should not be interpreted as endorsing any specific methodological approach to conjoint analysis, it can facilitate future training activities and discussions of good research practices for the application of conjoint-analysis methods in health care studies.

Cited by 1,493 publications

References 49 publications

Women’s and health professionals’ preferences for prenatal tests for Down syndrome: a discrete choice experiment to contrast noninvasive prenatal diagnosis with current invasive tests

Women’s and health professionals’ preferences for prenatal tests for Down syndrome: a discrete choice experiment to contrast noninvasive prenatal diagnosis with current invasive tests

Orphan drugs policies: a suitable case for treatment

Clinical Factors and the Decision to Transfuse Chronic Dialysis Patients

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