Conidiobolomycosis: An Unusual Fungal Disease—Our Experience

Das, Sudip; Das, Chhanda; Maity, Amit Bikram; Maiti, Prabal K.; Hazra, Tapan Kanti; Bandyopadhyay, Saumendra Nath

doi:10.1007/s12070-017-1182-6

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…The infection is hypothesized to spread by inhalation of spores or trivial trauma to the upper respiratory mucosa [6] . It usually occurs in immunocompetent adult males with agricultural exposure, increasing their risk of coming in contact with spores [7] . We did not suspect Conidiobolomycosis in our patient initially because of the rarity of the disease and the absence of risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Conidiobolomycosis is characterized by a chronic granulomatous infection beginning in the mucosa over the inferior turbinate, giving rise to a lateral nasal mass that causes nasal obstruction [7] . It spreads via the submucosa to the subcutaneous tissue over the nose, the upper lip, and the cheeks, resulting in a characteristic facial deformity with obliteration of the nasolabial and nasomaxillary creases [8] .…”

Section: Discussionmentioning

confidence: 99%

“…Complications such as nasal obstruction, rhinorrhoea, epistaxis, and recurrent bacterial sinusitis may occur and are often difficult to treat, warranting a timely diagnosis and treatment of the infection [4] . The differential diagnoses in these cases are Rhinoscleroma, lymphedema, lymphoma, mucormycosis, and chronic granulomatous aspergillosis [7] . Given the clinical features, fungal smear, and HPE findings, these alternative diagnoses were less likely.…”

Section: Discussionmentioning

confidence: 99%

“…Specific protocols for antifungal therapy have not been described because of the rarity of the disease, although successful treatment with a combination of a saturated solution of potassium iodide and azoles has been reported in India [7] . We preferred Voriconazole monotherapy because of the availability of therapeutic drug monitoring at our center and more predictable drug concentrations, to which the patient responded well.…”

Section: Discussionmentioning

confidence: 99%

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Conidiobolomycosis: a diagnostic challenge (case report)

Bhagia¹,

Bansal

Koparkar

2021

IJS Short Reports

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Introduction and importance: Conidiobolomycosis is a rare chronic granulomatous fungal infection affecting the rhino-facial region. It usually occurs in immunocompetent males with agricultural exposure. A high index of suspicion is required to achieve a timely diagnosis in such cases, as the infection usually responds well to early antifungal therapy. Case presentation: We share a case of this disease occurring in a 21-year-old male presenting with a right nasal mass and external nasal swelling. It could not be diagnosed correctly over 2 months at various hospitals before he visited our center, where we excised the mass via functional endoscopic sinus surgery and identified Conidiobolus coronatum as the causative agent based on histopathologic examination, and MALDI-TOF. The facial deformity resolved after 3 months of therapy with oral Voriconazole. Clinical discussion: In this report, we discuss the pathogenesis of Conidiobolomycosis, our diagnostic approach, and the use of functional endoscopic sinus surgery, which has not been reported extensively in the existing literature. Conclusion: In endemic regions, conidiobolomycosis should be considered amongst the differential diagnosis of a nasal mass associated with facial swelling. A multidisciplinary team approach is required to arrive at a timely diagnosis and begin early antifungal therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Conidiobolomycosis: a diagnostic challenge (case report)

Bhagia¹,

Bansal

Koparkar

2021

IJS Short Reports

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“…The main species causing basidiobolomycosis is B. ranarum , but cases of B. meristosporus , B. omanensis , and B. haptosporus have also been reported ( Kamalam and Thambiah, 1984 ; Sanglard et al, 2017 ; Bshabshe et al, 2020 ; Al-Hatmi et al, 2021 ). Finally, conidiobolomycosis is caused by Conidiobolus coronatus, Conidiobolus pachyzygosporus, Conidiobolus lamprauges , and Conidiobolus incongruus ( Walsh et al, 1994 ; Wüppenhorst et al, 2010 ; Kimura et al, 2011 ; Das et al, 2019 ; Stavropoulou et al, 2020 ).…”

Section: Definitions Of Terms and Pathogens Associated With Entomopht...mentioning

confidence: 99%

An old confusion: Entomophthoromycosis versus mucormycosis and their main differences

Acosta-España

Voigt

2022

Front. Microbiol.

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Fungal diseases were underestimated for many years. And the global burden of fungal infections is substantial and has increased in recent years. Invasive fungal infections have been linked to several risk factors in humans which basically depend on the individual homeostasis of the patients. However, many fungi can infect even apparently healthy people. Knowledge of these pathogens is critical in reducing or stopping morbidity and/or mortality statistics due to fungal pathogens. Successful therapeutic strategies rely on rapid diagnosis of the causative fungal agent and the underlying disease. However, the terminology of the diseases was updated to existing phylogenetic classifications and led to confusion in the definition of mucormycosis, conidiobolomycosis, and basidiobolomycosis, which were previously grouped under the now-uncommon term zygomycosis. Therefore, the ecological, taxonomic, clinical, and diagnostic differences are addressed to optimize the understanding and definition of these diseases. The term “coenocytic hyphomycosis” is proposed to summarize all fungal infections caused by Mucorales and species of Basidiobolus and Conidiobolus.

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