Congestive heart failure model representing aortic banding induced hypertrophy: A study to analyse extent of pressure overload and alteration in myocardial structure and function

Abstract

Congestive Heart failure (CHF) is a severe pathology representing a major public health problem in industrialized nations which is increasing in prevalence and incidence. The aortic banding rat model provides steady progression of cardiac dysfunction under chronic pressure overload. Present study evaluated two abdominal aortic constriction techniques including constriction of aorta above renal arteries and between renal arteries. The extent of constriction was varied with 22 G and 24 G needles and the duration for evaluation of CHF was also varied by terminating the banded animals after 6 and 8 weeks of banding. Various hemodynamic, ECG and tissue parameters were evaluated after banding to see the progression of CHF. The findings revealed that the constriction of the aorta above both renal arteries with 24 G needle is a better technique amongst other tested banding techniques as the rate of progression of CHF was found to be maximum with it. On the basis of above study, it was concluded that, aortic banding above both renal arteries with 24 G needle is a better technique for induction of pressure overload and for further observation in transition of the cardiac compensatory to decompensatory phase, the duration of the model needs to be prolonged.

A Heart Failure Model Established by Pressure Overload Caused by Abdominal Aortic Contraction in Rat

“…Our modeling method directly leads to increased afterload of cardiac ejection by constricting the abdominal aorta, thus resulting in stable hypertension that is not susceptible to drug effects, which is conducive to the study of various pathological changes from hypertension-induced cardiac hypertrophy to chronic heart failure and has good clinical relevance [ 28 , 29 ]. Therefore, the improved model of heart failure in rats caused by abdominal aortic contraction is worth generalizing, and this paper provides a theoretical basis for the study of heart failure.…”

Soft robotic platform for progressive and reversible aortic constriction in a small-animal model

“…Different degrees of aortic banding can result in various levels of cardiac remodeling and diastolic dysfunction ( 16 , 17 ). The degree of constriction can be coarsely controlled by choice of the size of the needle used during ligation, which determines how tight the knot around the aorta will be ( 18 ).…”

Soft robotic platform for controlled, progressive and reversible aortic constriction in a small animal model

“…Different degrees of aortic banding can result in various levels of cardiac remodeling and diastolic dysfunction [20,21]. The degree of constriction can be coarsely controlled by choice of the size of the needle used during ligation, which determines how tight the knot around the aorta will be [22].…”