Congestive Heart Failure and Upper Digestive Endoscopic Lesions

Cosma, Adriana-Stela; Bănescu, Claudia; Mocan, Simona; Balla, Beata; Negovan, Anca

doi:10.2478/amma-2019-0001

Cited by 3 publications

(5 citation statements)

References 31 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antiplatelets (e.g., aspirin [ 159 ] and clopidogrel [ 160 ]) and/or anticoagulants (e.g., warfarin [ 161 ]) are known to increase GI bleeding by causing GI lesions, especially if used in combination [ 162 , 163 , 164 ]. Such complex dual and triple antithrombotic drug combinations increase the risk of GI bleeding substantially [ 165 , 166 ]. Remarkably, the presence of comorbidities amplifies the risk of GI bleeding when these agents are used, with HF being an independent risk factor [ 162 , 167 , 168 , 169 ].…”

Section: Causes Of Iron Deficiency In Heart Failurementioning

confidence: 99%

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Alnuwaysir

Hoes

Veldhuisen

et al. 2021

JCM

View full text Add to dashboard Cite

Iron is an essential micronutrient for a myriad of physiological processes in the body beyond erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF), with a prevalence reaching up to 59% even in non-anaemic patients. ID impairs exercise capacity, reduces the quality of life, increases hospitalisation rate and mortality risk regardless of anaemia. Intravenously correcting ID has emerged as a promising treatment in HF as it has been shown to alleviate symptoms, improve quality of life and exercise capacity and reduce hospitalisations. However, the pathophysiology of ID in HF remains poorly characterised. Recognition of ID in HF triggered more research with the aim to explain how correcting ID improves HF status as well as the underlying causes of ID in the first place. In the past few years, significant progress has been made in understanding iron homeostasis by characterising the role of the iron-regulating hormone hepcidin, the effects of ID on skeletal and cardiac myocytes, kidneys and the immune system. In this review, we summarise the current knowledge and recent advances in the pathophysiology of ID in heart failure, the deleterious systemic and cellular consequences of ID.

show abstract

Section: Causes Of Iron Deficiency In Heart Failurementioning

confidence: 99%

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Alnuwaysir

Hoes

Veldhuisen

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…This study showed a decrease in endoscopic procedures being performed throughout the follow-up period in patients with heart failure. These findings may be due to a decrease in the incidence of upper GI bleeding as a cause of anemia in recent years, greater use of gastric protectors such as omeprazole, and a decrease in the use of non-steroidal anti-inflammatory drugs or anti-aggregants at high doses [ 19 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Trends and Clinical Impact of Gastrointestinal Endoscopic Procedures on Acute Heart Failure in Spain (2002–2017)

Méndez‐Bailón

Jiménez-García

Muñoz‐Rivas

et al. 2021

JCM

View full text Add to dashboard Cite

Introduction: Heart failure decompensation can be triggered by many factors, including anemia. In cases of iron deficiency anemia or iron deficiency without anemia, endoscopic studies are recommended to rule out the presence of gastrointestinal neoplasms or other associated bleeding lesions. Objectives: The aims of this study were to (i) examine trends in the incidence, clinical characteristics, and in-hospital outcomes of patients hospitalized with heart failure from 2002 to 2017 who underwent esophagogastroduodenoscopy (EGD) and/or colonoscopy, and to (ii) identify factors associated with in-hospital mortality (IHM) among patients with heart failure who underwent an EGD and/or a colonoscopy. Methods: We conducted an observational retrospective epidemiological study using the Spanish National Hospital Discharge Database (SNHDD) between 2002 and 2017. We included hospitalizations of patients with a primary discharge diagnosis of heart failure. Cases were reviewed if there was an ICD-9-CM or ICD-10 procedure code for EGD or colonoscopy in any procedure field. Multivariable logistic regression models were constructed to identify predictors of IHM among HF patients who underwent an EGD or colonoscopy. Results: A total of 51,187 (1.32%) non-surgical patients hospitalized with heart failure underwent an EGD and another 72,076 (1.85%) patients had a colonoscopy during their admission. IHM was significantly higher in those who underwent an EGD than in those who underwent a red blood cell transfusion (OR 1.10; 95%CI 1.04–1.12). However, the use of colonoscopy seems to decrease the probability of IHM (OR 0.45; 95%CI 0.41–0.49). In patients who underwent a colonoscopy, older age seems to increase the probability of IHM. However, EGD was associated with a lower mortality (OR 0.60; 95% CI 0.55–0.64). Conclusion: In our study, a decrease in the number of gastroscopies was observed in relation to colonoscopy in patients with heart failure. The significant ageing of the hospitalized HF population seen over the course of the study could have contributed to this. Both procedures seemed to be associated with lower in-hospital mortality, but in the case of colonoscopy, the risk of in-hospital mortality was higher in elderly patients with heart failure and associated neoplasms. Colonoscopy and EGD seemed not to increase IHM in patients with heart failure.

show abstract

“…Moreover, an elevated level of heart rate is also noticed in these individuals. 14,15 The etiology of the pylori bacterium influences heart diseases also; antibodies of the such bacterium are found in patients with cardiovascular diseases. Moreover, it makes digestive complications and disrupts the mechanism of various factors including cytokines, fibrinogen, triglycerides, lipoprotein, C-reactive protein, and white blood cells.…”

Section: Introductionmentioning

confidence: 99%

“…It also triggers other problems that lead to cardiovascular diseases such as atherosclerosis and the prothrombic state of heart diseases. 4,14,16,17 Digestive manifestations are either directly or indirectly influenced by helicobacter pylori infection such as IL-1, TNF-a, interferon (IFN)-g, leukotriene C4, and platelet-activating factor. It also contributes to inflammatory and chronic immune responses.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aiding gastrointestinal diagnostic laboratory by designing a device for the non invasive detection of peptic ulcer

Faiz

Murad

Khalid

et al. 2023

Proc Inst Mech Eng H

View full text Add to dashboard Cite

Peptic ulcer (PU) has been recognized as an utmost gastrointestinal problem that affects the lining of the stomach and duodenum, specifically triggering soreness. It is a life-threatening condition, while roots of the infection are not identified yet. There are various risk factors for the cause of peptic ulcer disease, but the most significant is “Helicobacter pylori” (H. pylori). The detection of this disease involves different invasive procedures which are painful and not feasible for everyone. The aim of this device is to identify the peptic ulcer non-invasively by unmasking the presence of H. Pylori bacterium by monitoring crucial parameters of the disease which include respiration rate, heart rate, ECG, pH of Saliva, and temperature. Multiple investigations related to PU authenticate the alteration in these physicochemical aspects of the body. The increase in the level of stomach acid in PU is responsible for belching and bloating. Heart rate, temperature, and respiratory rate are also elevated during peptic ulcers while the pH of Saliva is decreased toward the acidic side. The disturbance in the QRS complex of the ECG wave is also observed. These biosignals are examined as analog input from the body, sent into MCP3008, and converted into digital input signals. Then these digital inputs are directed toward Raspberry pi 3 which processes, received inputs, and shows output on the LCD. The values of parameters obtained are then compared with standard values and a conclusion is made that whether a patient has a peptic ulcer or not.

show abstract

Congestive Heart Failure and Upper Digestive Endoscopic Lesions

Cited by 3 publications

References 31 publications

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Trends and Clinical Impact of Gastrointestinal Endoscopic Procedures on Acute Heart Failure in Spain (2002–2017)

Aiding gastrointestinal diagnostic laboratory by designing a device for the non invasive detection of peptic ulcer

Contact Info

Product

Resources

About