CONGENITALLY CORRECTED TRANSPOSITION OF THE GREAT ARTERIES A Clinical Study of 101 Cases

Abstract

The anatomy, natural history, clinical features and symptomatology of 101 cases of congenitally corrected transposition of the great arteries (C-TGA) diagnosed over a 20-year period at Hospital for Sick Children, Toronto, Ontario, is reported. Only 1 patient had no association lesion and only 14 an intact ventricular septum. Pulmonary stenosis was present in a little more than half of the patients. Left A-V value involvement existed in 21 patients. In spite of the hich incidence of associated lesions with prognosis was better than expected. Seventy-six patients were alive at the end of the study, no one being critically ill. No death occurred among the patients with intact ventricular septum. Patients with pulmonary stenosis as a group developed symptoms later, were less handicapped and had a better prognosis than those without a pulmonary stenosis. One third of the patients had dysrhythmias. Eight patients having a 3rd degree AV-block. Auscultatory findings were not of too great a help when diagnosing C-TGA. Forty-seven patients had a single second sound, of these 37 had pulmonary stenosis. In 60% of the patients, where information was available, the second sound was reported to be of normal intensity. Our surgical experience is documented and discussed. Palliative procedures were done with successful results and low mortality. Totally corrective procedures were performed in 9 patients with 4 deaths.

Congenitally Corrected Transposition of the Great Arteries in a 65-Year-Old Woman.

“…[1][2][3][4][5][6] The majority of patients (74 %) have a ventricular septal defect or pulmonary stenosis (74%), or both cardiac anomalies. 4) They often produce congestive heart failure due to systemic AV valve regurgitation and experience gradual deterioration of the systemic ventric- ular (morphologic right ventricle) function.…”

“…CONGENITALLY corrected transposition of the great arteries (CCTGA) is a rare cardiac anomaly 1) characterized by atrioventricular (AV) and ventriculoarterial discordance. However, few patients with this anomaly survive past 50 years of age because of associated congenital intracardiac anomalies such as pulmonary stenosis and ventricular septal defect, or systemic AV valve (anatomical tricuspid) regurgitation and subsequent development of systemic (morphological right) ventricular dysfunction or heart block.…”

Progressive Tricuspid Valve Disease in Patients With Congenitally Corrected Transposition of the Great Arteries

“…1,4 Clinically significant tricuspid insufficiency (TI) has been reported in 20% to 50% of patients with CTGA. 2,3,[5][6][7] In addition to the severity of the anatomic abnormality of the valve, other potential predisposing factors for the development of important TI have been proposed but not well documented. Several investigators have noted the development or exacerbation of TI shortly after open heart surgery for closure of a ventricular septal defect (VSD) with or without pulmonic stenosis (PS), 2,3,7,8 whereas others have not found such a relation.…”

Midterm evaluation of echocardiographic examination, cardiac catheterization findings and surgical results of patients with congenitally corrected transposition of great arteries: A single center experience

“…In our study, 6 (7.6%) patients had no associated cardiac anomalies, which is similar to the rate of 9% in the series reported by Lundstrom et al (12) . The most common concomitant anatomic pathologies were reported as VSD and pulmonary stenosis or pulmonary atresia with incidence rates of 70-84% and 24 to 76%, respectively (10,(12)(13)(14)(15) . In our study, 88.6% of the patients had VSD (most frequently large inlet to outlet VSD).…”