Congenital Varicella

Freud, Paul

doi:10.1001/archpedi.1958.02060060732015

Cited by 3 publications

(3 citation statements)

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“…Freud [100] described an infant who had transplacentally acquired disease and developed lesions on the 2nd day of life. None of the other 17 neonates in the nursery became infected, but the index infant had been isolated immediately, so exposure had been very brief.…”

Section: Nosocomial Chickenpox In the Nurserymentioning

confidence: 99%

Chickenpox, Measles, and Mumps

Gershon¹

2011

Infectious Diseases of the Fetus and Newborn

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Section: Nosocomial Chickenpox In the Nurserymentioning

confidence: 99%

Chickenpox, Measles, and Mumps

Gershon¹

2011

Infectious Diseases of the Fetus and Newborn

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“…Neonatal chickenpox has been occasionally referred to as ''congenital varicella'' or ''neonatal varicella syndrome''. 13,26,35 These terms do not allow a clear differentiation from the ''congenital varicella syndrome'' caused by maternal chickenpox in the first two trimesters.…”

Section: Neonatal Varicellamentioning

confidence: 99%

Neonatal Varicella

2001

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Neonatal varicella is mostly caused by maternal chickenpox acquired during the last 3 weeks of pregnancy. Transplacentally transmitted infections occur in the first 10 to 12 days of life, whereas chickenpox after that time is most likely acquired by postnatal infection. If the mother develops rash between days 4 and 5 antepartum to day 2 postpartum, generalized neonatal varicella leading to death occurs in up to 20% of affected cases. Neonatal chickenpox within the first 4 days after birth has usually been found to be mild. A fatal outcome has been reported in 23% of cases if neonatal chickenpox occurs between 5 and 10 to 12 days of age. Serological methods have been widely used to confirm clinical diagnosis. For rapid virological diagnostics, amplification of viral DNA in skin swabs by polymerase chain reaction is the method of choice. To prevent severe neonatal chickenpox, passive immunization is indicated. If varicella occurs, acyclovir treatment has to be administered promptly.

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“…Maternal infection near the time of delivery may spread to the fetus through intrauterine infection and give rise to perinatal or neonatal varicella. The disease can be an overwhelming disseminated infection with necrotic foci in lungs and abdominal viscera and a high mortality rate (Ehrlich et al, 1958;Freud, 1958). Some infants, on the other hand, develop a disease that resembles the normal mild form of childhood varicella (Newman, 1965).…”

Section: Primary Infectionmentioning

confidence: 99%