Congenital uveal malignant melanoma

Pukrushpan, Parnchat; Tulvatana, Wasee; Pittayapongpat, Rosana

doi:10.1016/j.jaapos.2013.11.020

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…In this series, there were no cases of congenital choroidal melanoma. Extensive literature review revealed only seven reports of congenital ocular melanoma30–36 with a tendency to be diffuse in newborns. In our patient, there was no associated retinal detachment or surface lipofuscin deposition, and the lesion was blackish-brown in colour which led to a clinical diagnosis of choroidal melanocytoma.…”

Section: Discussionmentioning

confidence: 99%

Congenital choroidal melanocytoma in a child with ocular melanocytosis

2019

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A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. The left eye was within normal limits. A clinical diagnosis of choroidal melanocytoma with ocular melanocytosis was made. Enucleation OD followed by orbital implant was performed. Histopathology showed features of diffuse ocular melanocytosis involving limbus, iris, ciliary body, choroid, sclera, optic nerve head, optic nerve sheath, along with choroidal melanocytoma with extrascleral tumour extension. We presume that choroidal melanocytoma may have arisen from ocular melanocytosis.

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Section: Discussionmentioning

confidence: 99%

Congenital choroidal melanocytoma in a child with ocular melanocytosis

2019

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“…Although uveal melanoma (UM) is traditionally considered a rare tumor, it is the most frequent primitive intraocular malignancy of the adults and the second most frequent melanoma not associated with epithelial structures (1)(2)(3). UM is extremely rare in children in whom it recognizes a congenital origin and is often diagnosed in advanced stages of disease with extraocular spreading (4). Choroid is the most common intraocular site involved, followed by ciliary bodies and, less frequently, iris (3).…”

Section: Introductionmentioning

confidence: 99%

The Macro-Autophagy-Related Protein Beclin-1 Immunohistochemical Expression Correlates With Tumor Cell Type and Clinical Behavior of Uveal Melanoma

et al. 2020

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Uveal melanoma, in spite of its rarity, represents the most common primitive intraocular malignant neoplasm of the adults; it affects choroid, ciliary bodied and iris and remains clinically silent for a long time, being accidentally discovered by routine ophthalmic exams. Prognosis of uveal melanoma is poor and frequently characterized by liver metastases, within 10–15 years from diagnosis. Autophagy is a multi-step catabolic process by which cells remove damaged organelles and proteins and recycle nutrients. It has been hypothesized that in early stages of tumorigenesis autophagy has a tumor suppressor role while, in more advanced stages, it may represent a survival mechanism of neoplastic cells in response to stress. Several proteins related to autophagy cascade have been investigated in numerous subtypes of human cancer, with overall controversal results. In this paper we studied the immunohistochemical expression of 3 autophagy related proteins (Beclin-1, p62 and ATG7) in a cohort of 85 primary uveal melanoma treated by primary enucleation (39 with metastasis and 46 non metastatic) and correlated their expression with clinico-pathological parameters and blood vascular microvessel density, in order to investigate the potential prognostic role of autophagy in this rare neoplasm. We found that high immunohistochemical levels of Beclin-1 correlated with a lower risk of metastasis and higher disease-free survival times, indicating a positive prognostic role for Beclin-1 in uveal melanoma. No statistically significative differences regarding the expression of ATG7 and p62 between metastatic and non metastatic patients was detected.

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“…Uveal melanoma (UM) is a rare neoplasm which, despite its rarity, represents the most common primary ocular malignancy in adults; it develops more frequently from melanocytes of the choroid but can also arise in other sites, such as ciliary bodies and iris [1]. UM has rarely been reported in pediatric ages, especially in advanced stages, with extraocular extension [2,3].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of ABCB5 as a Potential Prognostic Factor in Uveal Melanoma

et al. 2019

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Uveal melanoma represents the most common primary intraocular malignancy in adults; it may arise in any part of the uveal tract, with choroid and ciliary bodies being the most frequent sites of disease. In the present paper we studied ABCB5 expression levels in patients affected by uveal melanoma, both with and without metastasis, in order to evaluate if ABCB5 is associated with a higher risk of metastatic disease and can be used as a poor prognostic factor in uveal melanoma. The target population consisted of 23 patients affected by uveal melanoma with metastasis and 32 without metastatic disease. A high expression of ABCB5 was seen in patients with metastasis (14/23, 60.9%), compared to that observed in patients without metastasis (13/32, 40.6%). In conclusion, we found that ABCB5 expression levels were correlated with faster metastatic progression and poorer prognosis, indicating their role as a prognostic factor in uveal melanoma.

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Congenital uveal malignant melanoma

Cited by 12 publications

References 7 publications

Congenital choroidal melanocytoma in a child with ocular melanocytosis

Congenital choroidal melanocytoma in a child with ocular melanocytosis

The Macro-Autophagy-Related Protein Beclin-1 Immunohistochemical Expression Correlates With Tumor Cell Type and Clinical Behavior of Uveal Melanoma

Immunohistochemical Expression of ABCB5 as a Potential Prognostic Factor in Uveal Melanoma

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