Congenital talipes equinovarus (clubfoot): a disorder of the foot but not the hand

Abstract

Idiopathic (non-syndromic) congenital talipes equinovarus, or clubfoot, is a poorly understood but common developmental disorder of the lower limb, which affects at least 2 per 1000 Scottish births (ISD data). It is defined as a fixation of the foot in a hand-like orientation -in adduction, supination and varus -with concomitant soft tissue abnormalities. Despite advances in treatment, disability often persists. The aetiology of the condition has been little studied and is poorly understood. Neurological, muscular, bony, connective tissue and vascular mechanisms have been proposed, but the only firm evidence is that the mildest cases appear to be associated with intra-uterine posture. There is evidence for a genetic contribution to congenital talipes equinovarus aetiology. Its incidence varies with ethnic group, and we found that a family history is present in 24-50% of cases, depending on the population studied. Complex segregation analysis suggests that the most likely inheritance pattern is a single gene of major effect operating against a polygenic background. Possible mechanisms for congenital talipes equinovarus are discussed.

Sex Differences in the Congenital Anomalies: A Hospital Based Cross Sectional Study

“…Miedzybrodzka (2003). 26 also observed similar results. In present study, GI anomalies were slightly more in males with significant sex difference in relation to gut atresia was seen.…”

SOX9 overexpression plays a potential role in idiopathic congenital talipes equinovarus

“…Neurological, muscular, bony, vascular and connective tissue mechanisms have been hypothesized to be involved in the pathology of ICTEV; however, the specific roles of these mechanisms in ICTEV remain unclear. Previous studies in twins and various ethnicities, as well as pedigree analyses, have indicated that a genetic basis in combination with additional environmental factors is responsible for ICTEV (2)(3)(4)(5)(6). It is becoming increasingly clear that genetic factors are important for the pathogenesis of ICTEV.…”

Parâmetros biomecânicos da marcha em crianças com pé torto congênito unilateral e bilateral

“…Although foot is supinated, forefoot is pronated in relation to rearfoot, causing cavus. In addition, the rst metatarsal is more plantar exed 1 . Treatment for CF must be started as soon as deformities appear.…”