Congenital Spinal Lipomatous Malformations. Part 1. Spinal Lipomas, Lipomyeloceles, and Lipomyelomeningoceles

Rhodes, Roy H.

doi:10.1080/15513815.2019.1641859

Cited by 8 publications

(4 citation statements)

References 225 publications

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“…Spinal lipoma is the most common type, and its severity increases with age. TCS reduces lower limb mobility inconvenience, causes pain and deformity of the spine and lower limbs, and also causes defecation disorders and incontinence (21)(22)(23). However, most TCS is occult in the early stage without any symptoms.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of minimally invasive surgery in children with occult tethered cord syndrome

Xu¹,

He²,

Wang³

2022

Transl Pediatr

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Background: At present, the surgical treatment of occult tethered cord syndrome (OTCS) in children is mostly two types of minimally invasive surgery: filum terminalis laxity or filum terminalectomy. The clinical efficacy and safety of minimally invasive treatment and conservative treatment are still unclear. Therefore, this study will use the advantages of systematic review and meta-analysis to evaluate the objectivity, and explore the effect of minimally invasive surgery on children with occult tethered cord syndrome.Methods: A computer search was used to search PubMed, Embase, CNKI, Wanfang Database and other literature search websites about the randomized controlled trials (RCTs) of minimally invasive surgery in children with occult tethered cord syndrome and spinal lipoma. Professional journals were manually searched to avoid omissions. The search keywords were: occult myelolipoma, occult tethered cord syndrome, surgical treatment of tethered cord syndrome, occult tethered cord syndrome.Results: A total of 6 relevant literatures that could be used for meta-analysis were selected. A total of 425 subjects were included in the article, of which 132 were treated conservatively and 293 were treated surgically. The heterogeneity detection test statistics of the included studies were Chi 2 (Chi-squared test) =8.18, df (degree of freedom) =5, I 2 =39%<50%, Z=2.53, and the homogeneity of the included studies was good. The number of unimproved cases under conservative treatment was 40, accounting for 30.30%; the number of unimproved cases under surgical treatment was 33, accounting for 11.26%, and the total unimproved rate of the two groups accounted for 17.17%. The unimproved rate of the experimental group was significantly lower than that of the control group, and the difference was statistically significant (P=0.01).The results of bias analysis showed that there was no significant bias in the literature included in this study.Discussion: Meta-analysis results confirmed that minimally invasive surgery has a significant effect on the treatment of occult children with tethered cord syndrome. However, due to the small sample size of the included literature, further evaluation of the treatment risk is required.

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Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of minimally invasive surgery in children with occult tethered cord syndrome

Xu¹,

He²,

Wang³

2022

Transl Pediatr

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“…True lipomyelomeningoceles are complex anomalies and probably represent an earlier separation from the ectoderm than spinal cord lipomas. 87…”

Section: Spinal Cord Lipoma and Lipomyelomeningocelementioning

confidence: 99%

Embryology of Spinal Dysraphism and its Relationship to Surgical Treatment

Eagles

Gupta

2020

Can. J. Neurol. Sci.

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Spinal dysraphism is an umbrella term that encompasses a number of congenital malformations that affect the central nervous system. The etiology of these conditions can be traced back to a specific defect in embryological development, with the more disabling malformations occurring at an earlier gestational age. A thorough understanding of the relevant neuroembryology is imperative for clinicians to select the correct treatment and prevent complications associated with spinal dysraphism. This paper will review the neuroembryology associated with the various forms of spinal dysraphism and provide a clinical-pathological correlation for these congenital malformations.

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“…The incidence of spinal dysraphism is about 1-2/1000 live births, most being ODs, mainly myelomeningocele. 1 In open dysraphism (OD), the nervous tissue is in direct contact with the amniotic fluid at the intrauterine environment. 2 This may lead to a progressive trauma, inflammation and degeneration of the exposed neural placode enhancing spinal cord injury with progressive functional loss known as the "second hit".…”

Section: Introductionmentioning

confidence: 99%

“…The defect can be open with the neural placode exposed to the intrauterine environment or closed (covered by soft tissue). The incidence of spinal dysraphism is about 1–2/1000 live births, most being ODs, mainly myelomeningocele 1 . In open dysraphism (OD), the nervous tissue is in direct contact with the amniotic fluid at the intrauterine environment 2 .…”

Section: Introductionmentioning

confidence: 99%

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism

Bedei,

Krispin,

Sanz Cortes

et al. 2023

Prenatal Diagnosis

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ObjectiveTo evaluate the prenatal diagnosis of closed dysraphism (CD) and its correlation with postnatal findings and neonatal adverse outcomes.MethodsA retrospective cohort study including pregnancies diagsnosed with fetal CD by prenatal ultrasound (US) and magnetic resonance imaging (MRI) at a single tertiary center between September 2011 and July 2021.ResultsCD was diagnosed prenatally and confirmed postnatally in 12 fetuses. The mean gestational age of prenatal imaging was 24.2 weeks, in 17% the head circumference was ≤fifth percentile and in 25% the cerebellar diameter was ≤fifth percentile. US findings included banana sign in 17%, and lemon sign in 33%. On MRI, posterior fossa anomalies were seen in 33% of cases, with hindbrain herniation below the foramen magnum in two cases. Mean clivus‐supraocciput angle (CSA) was 74°. Additional anomalies outside the CNS were observed in 50%. Abnormal foot position was demonstrated prenatally in 17%. Neurogenic bladder was present in 90% of patients after birth.ConclusionArnold Chiari II malformation and impaired motor function can be present on prenatal imaging of fetuses with CD and may be associated with a specific type of CD. Prenatal distinction of CD can be challenging. Associated extra CNS anomalies are frequent and the rate of neurogenic urinary tract dysfunction is high.

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Congenital Spinal Lipomatous Malformations. Part 1. Spinal Lipomas, Lipomyeloceles, and Lipomyelomeningoceles

Cited by 8 publications

References 225 publications

A systematic review and meta-analysis of minimally invasive surgery in children with occult tethered cord syndrome

A systematic review and meta-analysis of minimally invasive surgery in children with occult tethered cord syndrome

Embryology of Spinal Dysraphism and its Relationship to Surgical Treatment

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism

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