Congenital simple hamartoma of the retinal pigment epithelium: a case report

Abstract

We report the case of a 56yearold woman who presented for a routine ophthal mological examination without visual symptoms and had a unilateral black retinal lesion that was detected by clinical examination. Fluorescein angiography and optical coherence tomography findings were compatible with a congenital simple hamartoma of the retinal pigment epithelium. It is very important to de tect this tumor and differentiate it from other pigmented fundus lesions that can com promise visual function or result in systemic conditions such as those caused by malignant tumors.

Long-Term Follow-Up of Congenital Simple Hamartoma of the Retinal Pigment Epithelium: A Case Report

“…In previous reports, FA revealed no fluorescence during the early phase and it became hyperfluorescent without leakage in the late phase [ 1 , 9 ]. In other reports, there is no leakage during any of the phases [ 6 , 8 ].…”

“…In previously reported cases, there was no progression of the lesion, and visual acuity had not changed [ 1 , 4 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The boundaries of the clear black lesion in our patient, which was located in the central fovea, also did not change, although the BCVA gradually declined for the first 3 years after the initial evaluation.…”

“…Because CSHRPE is asymptomatic, it is found incidentally in most cases [ 1 , 6 , 7 , 8 ]. To the best of our knowledge, the longest period of observation of a CSHRPE was 15 years by Laqua [ 2 ].…”

“…Shields et al [ 1 ] reported five cases and defined the lesions as CSHRPE in 2003. There have been only a few reports of CSHRPE worldwide and, to the best of our knowledge, only two Asian cases [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. The previous reports noted that fluorescein angiography (FA) and optical coherence tomography (OCT) were performed to diagnose CSHRPE, whereas one report analyzed CSHRPE with OCT angiography (OCTA) [ 5 ].…”

Congenital simple hamartoma of the retinal pigment epithelium with depigmentation at the margin in an Indian female

“…Gass [ 2 ] defined the retinal pigment epithelial hamartoma as “focal, nodular, jet black lesions that usually appear to involve the full thickness of the retina and to spill onto the inner retinal surface in an umbrella fashion”. However, the lesions may be flat [ 2 ], [ 3 ], [ 4 ] or also minimally elevated [ 5 ], [ 6 ]. Other names of this lesion are congenital RPE adenoma, congenital or primary RPE hyperplasia [ 7 ], and RPE hamartoma [ 2 ].…”