Congenital Sialolipoma of Parotid Gland: A Report of Rare and Recently Described Entity with Review of Literature

Bansal, Bhavna; Ramavat, Anurag Snehi; Gupta, Suchit; Singh, Sompal; Sharma, Amitabh; Gupta, Kusum; Mittal, Ashok; Kudesia, Madhur

doi:10.2350/06-09-0170.1

Cited by 21 publications

(20 citation statements)

References 3 publications

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“…Although a few foci of oncocytic cells might be encountered in some cases, this variant generally lacks a significant oncocytic component. Close resemblance of sialolipoma to normal salivary gland architecture and its occasional occurrence in childhood allowed some authors to suggest a hamartomatous origin [13][14][15][16][17][18]. The term sialolipoma was included in the most recent 2005 world health organization (WHO) Classification of Head and Neck Tumors [2].…”

Section: Sialolipoma (Non-oncocytic Adenolipoma)mentioning

confidence: 99%

“…In one series, sialolipoma and oncocytic lipoadenoma were the only variants that occurred in patients \20 years old [21]. Due to congenital occurrence in some patients, a hamartomatous origin was suggested by some authors [13,15,16,18]. Unlike salivary lipomas, sialolipoma and oncocytic lipoadenoma do not show a predilection for males.…”

Section: Oncocytic Lipoadenomamentioning

confidence: 99%

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Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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Fat-containing tumors of the salivary glands are uncommon. Their wide histological spectrum varies from pure lipomatous neoplasms similar to their cutaneous and soft tissue counterparts to mixed lipoepithelial lesions specific to the salivary glands. With few exceptions, these uncommon lesions affect mainly the elderly, with a mean age at presentation of C50 years and show a predilection for males. A few cases occur in childhood; some of them represent congenital lesions. In decreasing order of frequency, ordinary (soft-tissue type) lipoma, oncocytic lipoadenoma, non-oncocytic sialolipoma, and pleomorphic adenoma/myoepithelioma with extensive lipometaplasia are the main variants of fat containing tumors encountered in the salivary glands. While pleomorphic adenoma/myoepithelioma with lipometaplasia behave in the same way as their non-fat-containing counterparts, other lipomatous salivary gland tumors listed above are cured with simple excision and do not carry a risk of recurrence. Other lipoma variants (spindle cell lipoma, osteolipoma, fibrolipoma, angiolipoma, pleomorphic lipoma, lipoblastoma and hibernoma) are exceptionally rare in the salivary gland. Atypical lipomatous tumors/liposarcoma have been only rarely reported in the salivary gland and they behave in a similar fashion to their soft-tissue counterparts. Diffuse lipomatosis and lobular fatty atrophy are the two tumor-like lesions that might closely mimic sialolipoma, particularly in limited biopsy material without knowledge of the gross findings. This review summarizes the clinicopathological features of the main types of salivary fat-containing lesions and discusses their differential diagnoses.

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Section: Sialolipoma (Non-oncocytic Adenolipoma)mentioning

confidence: 99%

Section: Oncocytic Lipoadenomamentioning

confidence: 99%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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“…Sialolipoma can arise in either major or minor salivary glands, and the parotid gland is the most common location to occur [11]. At present, 30 cases of parotid sialolipoma have been reported (summarized in Table 1) [7,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. The age of patients ranged from 6 weeks to 74 years old (mean age: 39.4 years) with men and women almost equally affected.…”

Section: Discussionmentioning

confidence: 99%

Oncocytic Sialolipoma of Parotid Gland: Case Report and Literature Review

Ruangritchankul

Connor

Oakley

2018

Head and Neck Pathol

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Oncocytic sialolipoma is a very rare tumor of which only three cases have been reported. This entity is considered to be a variant of sialolipoma which harbours oncocytic nodules within a well-circumscribed lipomatous mass. We report a parotid mass in 73-year-old female that was difficult to diagnose in imaging and on biopsy. Ultrasonography and MRI demonstrated a mass with features thought to be consistent with lipoma. Twice needle core biopsies were performed. Both were indefinite for diagnosis. The first report favoured a lipoma and the second report suggested the lesion represented oncocytic hyperplasia or an oncocytoma. The microscopic examination of the excised surgical specimen demonstrated typical features of oncocytic sialolipoma, characterized by a predominately lipomatous component, sparse normal-appearing salivary gland tissue and multiple oncocytic nodules. This is the second case of oncocytic sialolipoma reported to occur in the parotid gland.

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“…A review of the English and German literature revealed approximately 40 cases (31 sialolipomas and 9 oncocytic lipoadenomas) reported variably as sialolipoma, oncocytic sialolipoma, oncocytic lipoadenoma, or adenolipoma. 10,[12][13][14][15][16][17][18][19][20][21][22][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] Sebaceous differentiation was a common feature in several lesions. 18,19,29,32 However, the term sialolipoma has been used variably and inconsistently in previous reports to designate lipoepithelial salivary gland lesions that varied greatly in their adipocytic and epithelial constituents.…”

Section: Discussionmentioning

confidence: 99%

“…29,38 Three previously reported cases were congenital. 39,41,43 Therefore, a hamartomatous origin has been suggested by some authors. 40,46 Unlike ordinary lipoma, definite male predilection was not observed for sialolipoma.…”

Section: Discussionmentioning

confidence: 99%

Lipomatous Salivary Gland Tumors

Agaimy

Ihrler²,

Märkl

et al. 2013

American Journal of Surgical Pathology

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Lipomatous neoplasms of the salivary glands are rare. Their wide histologic spectrum has not been sufficiently studied. We collected 31 fat-containing salivary gland lesions excluding pleomorphic adenoma and myoepithelioma with lipometaplasia. There were 19 male and 12 female patients aged 7 to 89 years (mean, 53 y). Tumors originated in the parotid (n=29) and the submandibular (n=2) gland. On the basis of the proportion and distribution of adipose tissue and the epithelial type, tumors could be categorized into 3 main groups: ordinary lipoma (n=20) identical to soft tissue lipoma but located within the salivary gland, oncocytic lipoadenoma (n=6) composed predominantly of oncocytes with variable fatty component, nononcocytic sialolipoma (n=4) composed of lobular fatty tissue (≥70%) with evenly distributed normal salivary tissue recapitulating the composition of normal salivary glands and microcystic lipoadenoma (n=1) composed of cystic ducts admixed with adipose tissue. The mean tumor size was 3.3, 3.8, and 2.9 cm for lipoma, oncocytic lipoadenoma, and nononcocytic sialolipoma, respectively. Associated diseases included Madelung disease with bilateral atypical lipomatous tumors of the neck and bilateral parotid lipoma (1), oncocytic lipoadenoma after irradiation for sinonasal adenocarcinoma (1), and periparotideal lipoma excised years before oncocytic lipoadenoma (1) and nononcocytic sialolipoma (1). No recurrence was recorded at a mean follow-up of 72 months (range, 6 to 184 mo). Sebaceous islands were seen in 5/6 oncocytic lipoadenomas and in 2/4 sialolipomas. Periductal inflammation/fibrosis was common in sialolipoma and oncocytic lipoadenoma. This study demonstrates the wide morphologic spectrum of fatty salivary gland lesions. Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases.

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Congenital Sialolipoma of Parotid Gland: A Report of Rare and Recently Described Entity with Review of Literature

Cited by 21 publications

References 3 publications

Fat-Containing Salivary Gland Tumors: A Review

Fat-Containing Salivary Gland Tumors: A Review

Oncocytic Sialolipoma of Parotid Gland: Case Report and Literature Review

Lipomatous Salivary Gland Tumors

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