Congenital rubella infection after previous immunity of the mother

Saule, H; Enders, Gisela; Zeller, Janice M.; Bernsau, U

doi:10.1007/bf00442222

Cited by 27 publications

(6 citation statements)

References 20 publications

(21 reference statements)

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“…On another hand, RV serology based on the use of the RV-EIA does not reliably distinguish between protective and nonprotective antibodies. Several cases of congenital rubella after reinfection during pregnancy have been reported during the last decade (7,8,11,20). In the course of this study, we have identified patients unable to raise an antibody response following RV vaccination.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of a whole-virus enzyme immunoassay (EIA) with a peptide-based EIA for detecting rubella virus immunoglobulin G antibodies following rubella vaccination

Zrein¹,

Joncas²,

Pedneault³

et al. 1993

J Clin Microbiol

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A total of 250 human serum samples were tested for rubella virus immunoglobulin G antibodies by two enzyme immunoassays (EIAs), one using whole rubella virus antigen and the other based on the use of synthetic peptide antigen. The samples were taken from 125 volunteers before and after their immunization with the RA 27/3 rubella vaccine. This study indicates that a synthetic peptide-based EIA can favorably replace current viral lysate-based EIAs to detect rubella virus antibodies following immunization. Because the synthetic peptide used in this newly developed EIA represents a putative neutralization epitope of the rubella virus, it could also be instrumental in determining rubella immune status and in assessing vaccine program efficiency.

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Section: Resultsmentioning

confidence: 99%

“…It is well established that immunity acquired following natural RV infection remains longer than the vaccine-induced immunity (12). In both instances however, effective immunity is not always established, as numerous cases of RV reinfections have been documented (2,7,8,11,12,17,20).…”

mentioning

confidence: 99%

Comparison of a whole-virus enzyme immunoassay (EIA) with a peptide-based EIA for detecting rubella virus immunoglobulin G antibodies following rubella vaccination

Zrein¹,

Joncas²,

Pedneault³

et al. 1993

J Clin Microbiol

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“…Morgan-Capner [62], reviewing this problem in detail, analysed 10 previously published cases: in his opinion 3 vaccinated women who developed intrauterine infection were probably reinfected; 3 of the others, all with rashes, probably had primary rubella and the rest were difficult to interpret. Six further reports [60,[63][64][65][66][67] have added 11 well-documented cases (1 with a rash) leading to fetal infection (3 abortions, 8 badly damaged babies). One of these reports lays down serological and historical criteria for diagnosing reinfection [60].…”

Section: Diagnosis Of Reinfectionmentioning

confidence: 99%

Laboratory diagnosis of rubella: past, present and future

Cradock-Watson

1991

Epidemiol. Infect.

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Fifty years ago in New South Wales the late Sir Norman Gregg [1] described congenital cataracts in 78 babies, 67 of whose mothers had had clinical rubella in early pregnancy; he concluded that the disease in the mother caused the abnormality in the baby. Gregg [1–3] and Swan [4, 5] and their colleagues reported that deafness, heart disease and microcephaly were also major components of the congenital rubella syndrome. The need to prevent this tragic outcome stimulated intensive work on laboratory diagnosis and vaccine development, leading to the isolation of rubella virus in 1962 and then to methods for antibody detection. These complementary advances established the two traditional pillars of virological diagnosis and opened the way to immunization, with the result that some countries are now on the verge of eliminating a disease which for over 100 years was regarded as no more than a mild and harmless exanthem of childhood.

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“…Auch Rötelnreinfektionen kön-nen zu einer RE führen. Allerdings ist das Risiko für eine RE nach Rötelnreinfektion sehr viel geringer als nach einer Primär-infektion [31,32,33] [39]. Eine aktive Impfung mit Röteln-bzw.…”

Section: Introductionunclassified

Measles, mumps and rubella virus infection in pregnancy. Possible adverse effects on pregnant women, pregnancy outcome and the fetus

Enders

Biber²,

Exler³

2007

Bundesgesundheitsbl.

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Measles, mumps and rubella are common childhood diseases. Therefore, frequent and intense contact with children of preschool age may be associated with a higher infection risk for childcare providers. This overview summarizes current knowledge on possible adverse effects of these infections on pregnant women, pregnancy outcome and the fetus. Acute rubella or mumps virus infections are apparently not more severe in pregnant than non-pregnant women. In contrast, measles virus infection in pregnancy is linked to a higher incidence of pneumonitis and hospitalization. Evidence of congenital defects due to fetal infection is only provided in case of rubella virus infection in early pregnancy. Following rubella virus infection in the first trimester an increased fetal loss rate was reported. In 1966, a prospective study showed also a significant association between maternal mumps in the first trimester and an increased risk of abortion. But other investigators could not confirm this association. Measles and rubella but not mumps virus infections are linked to an increased premature birth rate. Occurring in late pregnancy, all three infections can result in birth of an infected infant. But severe disease occurs rarely and is mostly reported for premature infants with early neonatal measles. Preventive measures, aimed to reduce the risk of infection or severe complications for pregnant childcare providers, should consider the individual history of the employee (e.g. previous immunizations or antibody test results), the current epidemiological situation and possible interventions like passive immunization in case of exposure to measles.

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Congenital rubella infection after previous immunity of the mother

Cited by 27 publications

References 20 publications

Comparison of a whole-virus enzyme immunoassay (EIA) with a peptide-based EIA for detecting rubella virus immunoglobulin G antibodies following rubella vaccination

Comparison of a whole-virus enzyme immunoassay (EIA) with a peptide-based EIA for detecting rubella virus immunoglobulin G antibodies following rubella vaccination

Laboratory diagnosis of rubella: past, present and future

Measles, mumps and rubella virus infection in pregnancy. Possible adverse effects on pregnant women, pregnancy outcome and the fetus

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