Congenital rubella in twins

Montgomery, Robert C.; Stockdell, Kenneth

doi:10.1016/s0022-3476(70)80303-1

Cited by 10 publications

(3 citation statements)

References 2 publications

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“…This is consistent with other reports in the medical literature that have found only one twin may be affected. [16][17][18] Among the 18 laboratory-confirmed cases in this study, congenital heart disease was the most common sign of CRS. It was seen in 13 children (72%).…”

Section: Discussionmentioning

confidence: 99%

Active surveillance for congenital rubella syndrome in Yangon, Myanmar

Thant

Myint

et al. 2004

Bull World Health Organ

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Objective Rubella vaccine is not included in the immunization schedule in Myanmar. Although surveillance for outbreaks of measles and rubella is conducted nationwide, there is no routine surveillance for congenital rubella syndrome (CRS). Therefore, we organized a study to assess the burden of CRS. Methods From 1 December 2000 to 31 December 2002 active surveillance for CRS was conducted among children aged 0-17 months at 13 hospitals and 2 private clinics in Yangon, the capital city. Children with suspected CRS had a standard examination and a blood sample was obtained. All serum samples were tested for rubella-specific IgM; selected samples were tested for rubellaspecific IgG and for rubella RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). Findings A total of 81 children aged 0-17 months were suspected of having CRS. Of these, 18 children had laboratory-confirmed CRS (7 were IgM positive; 7 were RT-PCR positive; and 10 were IgG positive at > 6 months of age). One additional child who tested positive by RT-PCR and whose mother had had rubella during pregnancy but who had a normal clinical examination was classified as having congenital rubella infection. During 2001-02 no rubella outbreaks were detected in Yangon Division. In the 31 urban townships of Yangon Division, the annual incidence was 0.1 laboratory-confirmed cases of CRS per 1000 live births. Conclusion This is the first population-based study of CRS incidence from a developing country during a rubella-endemic period; the incidence of CRS is similar to endemic rates found in industrialized countries during the pre-vaccine era. Rubella-specific IgG tests proved practical for diagnosing CRS in children aged > 6 months. This is one of the first studies to report on the use of rubellaspecific RT-PCR directly on serum samples; further studies are warranted to confirm the utility of this method as an additional means of diagnosing CRS. Voir page 18 le résumé en français. En la página 18 figura un resumen en español. Keywords

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Section: Discussionmentioning

confidence: 99%

Active surveillance for congenital rubella syndrome in Yangon, Myanmar

Thant

Myint

et al. 2004

Bull World Health Organ

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“…Neonatal infections in twins have been caused by group A streptococci (case report of streptococcal sepsis in a mother and infant twins) [384], Salmonella species [385], Salmonella E. coli [384a], C. koseri (brain abscesses in twins) [156], malaria [386,387], coccidioidomycosis [388], cytomegalovirus infection [389][390][391], and rubella [392]. Neonatal infections in twins have been caused by group A streptococci (case report of streptococcal sepsis in a mother and infant twins) [384], Salmonella species [385], Salmonella E. coli [384a], C. koseri (brain abscesses in twins) [156], malaria [386,387], coccidioidomycosis [388], cytomegalovirus infection [389][390][391], and rubella [392].…”

Section: Infection In Twinsmentioning

confidence: 99%

Bacterial Sepsis and Meningitis

Nizet¹,

Klein²

2011

Infectious Diseases of the Fetus and Newborn

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“…Congenital infections in twin pregnancies have been documented with vertical transmission by several infectious agents including rubella, cytomegalovirus, Toxoplasma gondii, lymphocytic choriomeningitis virus, and most recently, Zika virus [25][26][27][28][29][30][31]. Outcomes of twin pregnancies affected by congenital infections vary with neither twin, one twin, or both twins having laboratory and/or clinical findings of the disease.…”

Section: Discussionmentioning

confidence: 99%

Discordant Clinical Outcomes in a Monozygotic Dichorionic-Diamniotic Twin Pregnancy with Probable Zika Virus Exposure. Case Report

Mercado

Daza²,

Moore

et al. 2020

TropicalMed

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Prenatal exposure to Zika virus (ZIKV) is associated with congenital anomalies of the brain and the eye and neurodevelopmental sequelae. The spectrum of disease outcomes may relate to timing of infection as well as genetic and environmental factors. Congenital infections occurring in twin pregnancies can inform the clinical spectrum of these conditions and provide unique information regarding timing of infection and in utero environment with disease pathophysiology. Herein, we report a monozygotic dichorionic-diamniotic twin pregnancy with probable prenatal ZIKV exposure identified through the Colombian ZIKV disease surveillance system. Multidisciplinary clinical evaluations were provided to the twins during their first three years of life through a national program for children with in utero ZIKV exposure. Laboratory evidence of congenital infection as well as microcephaly, brain, eye, and neurodevelopmental compromise related to prenatal ZIKV infection were identified in only one infant of the twin pregnancy. This is the first report of monozygotic twins discordant for Zika-associated birth defects. The evaluation of the pathophysiology of discordance in disease outcome for congenital infections in twin pregnancies may lead to a better understanding of potential complex environmental and genetic interactions between the mother, her offspring, and an infectious exposure.

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Congenital rubella in twins

Cited by 10 publications

References 2 publications

Active surveillance for congenital rubella syndrome in Yangon, Myanmar

Active surveillance for congenital rubella syndrome in Yangon, Myanmar

Bacterial Sepsis and Meningitis

Discordant Clinical Outcomes in a Monozygotic Dichorionic-Diamniotic Twin Pregnancy with Probable Zika Virus Exposure. Case Report

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