Congenital Pupillary-Iris-Lens Membrane with Goniodysgenesis

Cibis, Gerhard W.; Waeltermann, Joanne M.; Hurst, Edward; Tripathi, Ramesh C.; Richardson, Walter P.

doi:10.1016/s0161-6420(86)33659-5

Cited by 45 publications

(29 citation statements)

References 5 publications

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“…In previous reports, a relatively large percentage of patients with CPILMG developed pupillary closure with iris bombe and angle‐closure glaucoma (Cibis & Walton 2004). This patient required surgery for pupillary block glaucoma with closure of the visual axis.…”

mentioning

confidence: 96%

“…In 1986, Cibis and coworkers reported congenital pupillary‐iris‐lens membrane with goniodysgenesis (CPILMG) as a new clinical entity characterized by anomalies of the chamber angle and iris‐lens membrane (Cibis et al. 1986).…”

mentioning

confidence: 99%

“…Because the membrane often causes an ectopic pupil or pupillary block glaucoma, surgical intervention is sometimes required (Cibis et al. 1994; Robb 2001; Cibis & Walton 2004; Demidenko et al. 2009).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pupilloplasty for congenital pupillary‐iris‐lens membrane with 25‐gauge vitreous cutter

Kandori

Saishin

Shimojyo

et al. 2009

Acta Ophthalmologica

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mentioning

confidence: 96%

mentioning

confidence: 99%

See 1 more Smart Citation

Pupilloplasty for congenital pupillary‐iris‐lens membrane with 25‐gauge vitreous cutter

Kandori

Saishin

Shimojyo

et al. 2009

Acta Ophthalmologica

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“…1 Cibis and coworkers 2 postulated that these membranes arise from ectopic iris tissue. This entity has been called by a variety of names including congenital pupillary-iris-lens membrane with goniodysgenesis, congenital idiopathic microcoria, and fibrous congenital iris membranes.…”

mentioning

confidence: 99%

Congenital Fibrovascular Pupillary Membranes: Clinical and Histopathologic Findings

et al. 2012

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Purpose To report the clinical and histopathological findings associated with congenital fibrovascular pupillary membranes. Design Case series. Participants Seven infants; six with a unilateral congenital pupillary membrane and one with classic persistent fetal vasculature (PFV). Methods Patients underwent a membranectomy, pupilloplasty and/or a lensectomy. Histopathological examination was performed on the excised membranes. Main Outcome Measures Visual acuity and pupil size. Results Four of the 6 patients with a unilateral congenital pupillary membrane had one or more recurrences after a membranectomy and pupilloplasty. The most recent pupil size ranged from 2 to 5 mm in the affected eye. When last tested, the vision in the affected eye was excellent in 4 of the 6 patients. The two patients without recurrences of the pupillary membranes underwent multiple iris spincterotomies at the time of the initial surgery. Histopathological examination of two primary pupillary membranes showed fibrovascular tissue that did not stain for neuron specific enolase. Smooth muscle actin was only present in vascular walls. In contrast, histopathology of a recurrent pupillary membrane revealed collagenized fibrovascular tissue that was immunoreactive for smooth muscle actin. Finally, histopathology of the retrolenticular membrane excised from an infant with classic PFV was similar to the latter aside from hypercellularity. Conclusions Congenital fibrovascular pupillary membranes in infants are likely a variant of PFV that may recur if incompletely excised. The risk of these membranes recurring may be reduced by excising as much as the membrane as possible and enlarging the pupil with iris spincterotomies. A lensectomy should be avoided if possible.

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“…This entity must be distinguished from a progressive segmental congenital pupillary–iris–lens membrane with goniodysgenesis . Pupillary block requiring a peripheral iridectomy or iridotomy is not encountered in pupillary vascular remnants.…”

mentioning

confidence: 97%