Congenital cystic adenomatoid malformation (CCAM) is mostly recognized in children and adult presentation is rare. Here, a 42-year-old male patient was presented. He had a previous history of pneumothorax, and radiologically there were multiple bullous lesions in the right upper lobe, as well as a nodular lesion of 2 cm. He underwent right upper lobectomy and middle lobe wedge resection which revealed CCAM type I and hamartoma of the lung. Less than 70 adult cases of CCAM have been reported in the literature. Lung cancer accompanying CCAM or malignant transformation in adult are rarely described. But to our knowledge, this is the first adult case of CCAM with hamartoma. CCAM should be considered in the differential diagnosis of multicycstic lesions in adults with a history of pneumothorax, and the surgical resection is the treatment of choice.