Congenital malformations and season of birth: A brief review

Bailar, John C.; Gurian, Joan

doi:10.1080/19485565.1965.9987622

Cited by 26 publications

(8 citation statements)

References 13 publications

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“…The possible relationship between the occurrence of congenital malformations and the month of birth has been widely discussed (Bailar et al, 1965). Of the various malformations, congenital dislocation of the hip (CDH) has been singled out, because of the consistency of findings observed in widely separated localities of the Northern Hemisphere (Nagura, 1955;Pap, 1956;Record et al, 1958;Andren et al, 1963;Medalieetal.,1966).…”

Section: Introductionmentioning

confidence: 99%

Seasonal variations of congenital dislocation of the hip

Cohen

1971

Journal of Interdisiplinary Cycle Research

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Section: Introductionmentioning

confidence: 99%

Seasonal variations of congenital dislocation of the hip

Cohen

1971

Journal of Interdisiplinary Cycle Research

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“…The 1965 summary of early studies by Bailar and Gurian [37] concluded that they showed 'a marked winter [birth] excess in anencephaly, an equivocal winter excess in spina bifida, and no convincing cycle in hydrocephaly'. In 1977, Sandahl [38] reviewed 24 studies of anencephaly; 11 of them reported an excess of winter births, but the 13 others did not.…”

Section: Congenital Malformations Of the Cnsmentioning

confidence: 99%

Seasonal Birth Patterns of Neurological Disorders

et al. 2000

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Existing seasonal birth studies were reviewed for multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), epilepsy, cerebral palsy, congenital malformations of the central nervous system and mental retardation. Epilepsy appears to have the most consistent pattern, with an excess of births in winter and a deficit in September. MS, ALS and possibly Parkinson’s disease appear to have an excess of spring births. Studies of cerebral palsy are not conclusive, although there are suggestions that there may be an excess of summer births. The findings for Alzheimer’s disease, congenital malformations of the central nervous system, and mental retardation are contradictory and insufficient to draw any conclusions.

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“…No definite conclusions about seasonal variation in the undifferentiated materials of malformations can be drawn from the literature (see Bailar & Gurian (1965), Villumsen (1970) and Dale'n (1974) for reviews). However, most investigations imply a higher frequency of anencephalia and luxatio coxae (not included here) in children born during the winter months found that the incidence of malformations was 7 % in the month of June, which is significantly higher than for other months.…”

Section: Incidence Of Malformations In Relation To Time Of Birthmentioning

confidence: 98%

Influence of maternal distress during pregnancy on fetal malformations

Blomberg

1980

Acta Psychiatr Scand

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The aim of the study was to investigate whether emotional stress in a pregnant woman might have an adverse effect in the form of malformations on fetal development. The children of 1,263 women whose applications for legal abortion in 1960 had been refused were compared with the next children born in the same delivery wards and paired matched controls were thereby obtained. Results. 1) The incidence of malformations according to the criteria established by the Swedish Register of Malformations was 1.8% in the proband series as against 1.1% in the control series. 2) The incidence of malformation increased with higher age and lower social class in the proband series, whereas no such connection was found in the control series. 3) The incidence of malformations for children of abortion applicants 25 years of age and above from social class III was 3% in the proband series as against 0.6% in the control series (P = 0.017). 4) One malformation, cleft palate, occurred at a significantly (P less than 0.01) higher incidence than in the country as a whole, four cases against the expected value of 0.69. 5) Etiological analysis showed that three of the cases were chromosomal aberrations, all of them Down's syndrome, in two cases there was a genetic background and two cases were thalidomide-induced phocomelia. In three proband children there may have been a connection with the abuse of alcohol by the mother. 6) When the chromosomal, genetic and thalidomide cases are excluded, the preponderance of malformations in the proband children of mothers 25 years of age and above belonging to social class III still remains (2.2% vs. 0.3%, P = 0.017). Conclusion. The results may be seen as support for the hypothesis that emotional stress in a pregnant woman, operationally defined by the factor unwanted pregnancy, may interfere with fetal development and result in a higher incidence of malformations. The interference may occur directly via psycho-endocrinal or autonomous mechanisms or indirectly by the way in which the woman might act in this situation of stress, e.g. attempts to provoke abortion, neglect of proper food intake, excessive smoking, or the abuse of alcohol of drugs.

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Congenital malformations and season of birth: A brief review

Cited by 26 publications

References 13 publications

Seasonal variations of congenital dislocation of the hip

Seasonal variations of congenital dislocation of the hip

Seasonal Birth Patterns of Neurological Disorders

Influence of maternal distress during pregnancy on fetal malformations

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