Congenital malformations and psychosocial development in children conceived by in vitro fertilization

Morin, Norma C.; Wirth, Frederick H.; Johnson, David H.; Frank, L. Matthew; Presburg, Harry J.; Water, Virginia L. Van de; Chee, Elsbeth; Mills, James L.

doi:10.1016/s0022-3476(89)80069-1

Cited by 93 publications

(29 citation statements)

References 8 publications

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“…Our findings are reassuring and in line with the recent studies in young IVF children [2,4,7,8,10,11,14,[19][20][21][22][23][24][25] and at primary school age [12,17,18]. Olivennes et al [17] found, in a follow-up study of 422 IVF children aged 6 to 13 years, according to the French school system, that 92.2% of the children had at least average school achievement.…”

Section: Discussionsupporting

confidence: 90%

“…From the psychological point of view, mental and psychomotor development in the early years was an important focus. Although IVF pregnancies appear to be associated with an increased risk of multiple pregnancy, preterm delivery, low birth weight, [2,7,8,10,14,16,[21][22][23][24][25]. Developmental and neurological problems that were found at this young age were mainly related to prematurity, low birth weight, or multiple births [2,3,15].…”

Section: Introductionmentioning

confidence: 99%

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School functioning in 8- to 18-year-old children born after in vitro fertilization

et al. 2008

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The aim of this study was to examine the school functioning of 8-to 18-year-old children born after in vitro fertilization (IVF). We compared 233 children born after IVF to 233 matched control children born spontaneously from parents with fertility problems on measures of education level, general cognitive ability, school performance (need for extra help, repeating a grade, special education), and rates of learning and developmental disorders. No differences were found between IVF and control children on these measures of school functioning. More than 60% of adolescents at secondary school attended high academic levels (with access to high school or university). We conclude that children and adolescents born after IVF show good academic achievement and general cognitive ability. They do not experience any more educational limitations than the naturally conceived children and adolescents of the control group. The tendency of reassuring school functioning already found in younger IVF children has been shown to continue at secondary school age.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

School functioning in 8- to 18-year-old children born after in vitro fertilization

et al. 2008

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“…Morin et al 15 in an earlier study looking at IVF cohorts versus non-IVF cohorts concluded that the high average achievements by the cohort resulted from the high parental motivation ('wantedness') and their high socio-economic status. This was also seen in our study.…”

Section: Discussionmentioning

confidence: 99%

Two‐year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study

Agarwal

Loh

Lim

et al. 2005

BJOG

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“…[15][16][17][18] We have obtained comparable results in children from cryopreserved embryos, after including the child with Down's syndrome. The mean Griffiths's quotient in the cryopreserved embryo group and in controls was above the standard 100.…”

Section: Discussionmentioning

confidence: 99%

Outcome in children from cryopreserved embryos.

Sutcliffe

D'Souza

Cadman

et al. 1995

Archives of Disease in Childhood

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A cohort of 91 children from cryopreserved embryos and 83 control children who were conceived normally had their development assessed using the Griffiths's scales of mental development. The controls (81 singletons and two twins) of a similar age, sex, and social class were selected from siblings, cousins, and peers of the cryopreserved embryo group (68 singleton, 20 twins, and three triplets). Children from cryopreserved embryos had a lower mean birth weight and mean gestational age and a higher proportion were born by caesarean section. One child from the cryopreserved embryo group had Down's syndrome, three had squints, and four had conductive hearing loss while in the control children, six had squints, and nine had conductive hearing loss. In both groups, including the child with Down's syndrome, the mean Griffiths's quotient was greater than the standard 100. In the children from cryopreserved embryos, the singleton and multiple birth subgroups had statistically similar assessment results. The mean (SD) Griffiths's quotient was 105-69 (13-55) in children from cryopreserved embryos and 108-18 (9.80) in controls at a chronological age of 25 08 (12.86) and 29-19 (14-65) months respectively. Overall, the development in children from cryopreserved embryos did not cause concern though formal testing had highlighted small differences compared with other children conceived normally and of a similar social class.(Arch Dis Child 1995; 72: 290-293)

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Congenital malformations and psychosocial development in children conceived by in vitro fertilization

Cited by 93 publications

References 8 publications

School functioning in 8- to 18-year-old children born after in vitro fertilization

School functioning in 8- to 18-year-old children born after in vitro fertilization

Two‐year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study

Outcome in children from cryopreserved embryos.

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