Congenital lobar emphysema in congenital cytomegalovirus infection

Carrol, Enitan D.; Campbell, Morag; Shaw, Benjamin A.; Pilling, David

doi:10.1007/bf03178047

Cited by 33 publications

(29 citation statements)

References 8 publications

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“…Congenital cartilage defect is the most common cause (25%) followed by mucosal folds, septa, mucosal plugs and anomalous vaculature causing bronchial obstruction [2]. Bronchial inflammation and obstruction secondary to congenital cytomegalovirus infection has been reported as a cause of CLE [3]. However, the exact cause of CLE is difficult to determine, and no apparent cause is found in 50% of the cases.…”

Section: Discussionmentioning

confidence: 95%

“…The majority of cases present in the neonatal period with signs of acute or chronic respiratory distress [2]. There are only a few reports of CLE in the literature with prenatal sonographic features documented [3][4][5][6][7]. On all these occasions the diagnosis was not suspected antenatally and only histology later confirmed the presence of CLE.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Sonographic Features of Congenital Lobar Emphysema

2001

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The prenatal sonographic features of congenital lobar emphysema (CLE) have not been well characterised. Five cases have been reported in the literature and on all these occasions either an echogenic (3) or a cystic (2) lung lesion was detected prenatally and the diagnosis was confirmed after the operation. This is the sixth case of CLE in the literature with prenatal sonographic features documented. The prenatal scans of a 23-year-old lady performed at 22 weeks of gestation revealed cystic lesions and increased echogenicity of the right fetal lung. There were no other anomalies and the karyotype was normal. The lesion decreased in size at 28 weeks and the baby was born by a normal vaginal delivery at 41 weeks. CT scan performed on day 6 confirmed cystic changes on the right lung with compression of the right lower lobe. A repeat CT scan performed at 4 months revealed extensive cystic changes in a hyper-inflated right lung and mediastinal shift to the left. At operation, abnormally inflated right upper and middle lobes were found suggesting a CLE. There were no subsequent complications after removal and histology confirmed CLE. The reported cases are reviewed and the prenatal sonographic features of CLE are discussed.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Prenatal Sonographic Features of Congenital Lobar Emphysema

2001

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“…Intrinsic obstruction involves dysplastic bronchial cartilage or endobronchial lesion with blockage due to mucosal fold, septa, or mucosal plugs [6]. Diffuse bronchial inflammation secondary to congenital cytomegalovirus infection has been reported as a cause of CLE [8]. However, the exact cause of CLE is difficult to determine, and a definitive cause cannot be identified in approximately 50% of cause [6].…”

Section: Discussionmentioning

confidence: 99%

Congenital lobar emphysema with cystic lung abnormality: Antenatal ultrasound appearance

Lee

Jeong

Joo

et al. 2012

Korean J Obstet Gynecol

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A 33-year-old woman at 23 +2 weeks of gestational age was referred for consultation due to the findings of a cyst in the right lung of the fetus. Prenatal ultrasound showed a 3 cm-sized hypoechogenic cyst, suggesting congenital cystic adenomatoid malformation. As the cyst grew and compressed the heart, serial cyst aspirations were performed. The cyst was proved to be congenital lobar emphysema on postnatal histopathologic exam. No other anomaly was found. Only few cases of congenital lobar emphysema (CLE) have been reported up to date and the prenatal diagnosis is extremely rare. Typically, fetal sonographic features of CLE have a bright echogenic lung and, to date, only 3 cases have been reported to have a cystic lesion. We report a case of a fetus with a cystic lung abnormality and postnatally proved congenital lobar emphysema.

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“…4 Vascular rings that produce compression, bronchial stenosis, bronchial torsion, bronchogenic cysts, polyalveolar lobe and congenital CMV infection have also been reported. [5][6][7][8] CLE is described in twins and occasionally from same family 9 but in 40% of cases, the cause is unknown. The age of onset of symptoms ranges from a few days after birth to 6 months.…”

Section: Introductionmentioning

confidence: 99%