Congenital Linear Becker’s Nevus, with Underlying Breast Hypoplasia that Spontaneously Corrected during Pregnancy: Role of Androgen Receptors

Abstract

For nearly 30 years, there have been studies investigating potential associations between androgens and Becker's nevi [7]. Considering that the state of pregnancy promotes a relative anti-androgen profile (as a consequence of increased sex-hormone binding globulin, decreased AbstractBecker's nevus is a pigmented cutaneous hamartoma that is normally localized to the upper torso. It is more commonly found in adolescent males and may form part of the Becker's nevus syndrome, in association with other features which may include overlying hypertrichosis, chest wall, breast or limb hypoplasia and scoliosis. Congenital and linear lesions have been reported but are very rare. We describe here a case of a congenital, linear nevus with histological features diagnostic of a Becker's nevus, with associated underlying breast hypoplasia. We confirm increased androgen receptors within her nevus and consequently, when our patient became pregnant, her relative antiandrogen profile enabled physiological enlargement of the previously hypoplastic breast beneath this nevus. Jo u r n a l o f Clini c a l T r ia ls

Acquired linear Becker′s nevus on lower limb in blaschkoid pattern

“…The lesions may have various shapes but classically have a geographic or block-like configuration in an irregular fashion; however, a blaschkoid pattern or linear pattern has been reported in the literature in a few congenital cases. [1,3] This abnormal phenotypic expression may be due to the somatic mutation occurring only in the affected segment of the body leading to linear pattern along with block configuration of some dermatoses. Blaschko's lines represent a pattern assumed by many different nevoid and acquired skin diseases on skin and mucosa.…”