Congenital leukaemia after heavy abuse of permethrin during pregnancy

Borkhardt, Arndt; Wilda, Maximiliano; Fuchs, U; Gortner, Ludwig; Reiss, Irwin K M

doi:10.1136/fn.88.5.f436

Cited by 40 publications

(18 citation statements)

References 11 publications

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“…One nested case-control study reported a moderate increase in premature births among workers in Columbian greenhouses [11]. Other studies have found an association between prenatal pesticide exposure and fetal growth delay [12][13][14]; various birth defects, including orafacial defects [15], cryptorchidism [16][17][18], musculoskeletal defects [19], limb reduction defects [20,21], and neural tube defects [20,22,23]; and childhood leukemia [24,25].…”

Section: Introductionmentioning

confidence: 99%

Female Farmworkers’ Perceptions of Pesticide Exposure and Pregnancy Health

Flocks

Kelley

Economos

et al. 2011

J Immigrant Minority Health

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Occupational pesticide exposure may be hazardous to pregnant farmworkers, yet few studies have focused on the health of female farmworkers distinct from their male counterparts or on the impact of agricultural work tasks on pregnancy outcomes. In the current community-based participatory research study, researchers conducted five focus groups with female nursery and fernery workers in Central Florida to enhance knowledge of attitudes about occupational risks and pregnancy health and to gather qualitative data to help form a survey instrument. This article presents the results from questions focused on pesticide exposure and its impact on general, reproductive, pregnancy, and fetal health. Workers reported a belief that pesticide exposure could be hazardous to pregnancy health; descriptions of symptoms and health concerns believed to be related to farmwork and to pesticide exposure; and descriptions of barriers preventing them from practicing safer occupational behaviors.

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Section: Introductionmentioning

confidence: 99%

Female Farmworkers’ Perceptions of Pesticide Exposure and Pregnancy Health

Flocks

Kelley

Economos

et al. 2011

J Immigrant Minority Health

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“…In addition, leukaemogenesis is considered to be affected by interactions between genes and environments [13]. In particular, it was reported that potential carcinogens from the environment or their metabolites, such as dipyrone [9] and permethrin [10], cause DNA damage that induces irrepairable chromosomal breaks and thus leads to initiation and progression of leukaemia [13,14].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia)

Rimando

Chua

Yuson³

et al. 2008

Bioscience Reports

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In the present paper, we examined the incidence of polymorphic genes involved with the detoxification of exogenous chemicals, including carcinogens, namely GSTT1 (glutathione transferase theta1), GSTM1 (glutathione transferase micro1) and NQO1 (NAD(P)H:quinone oxidoreductase 1) in 60 Filipino paediatric patients with ALL (acute lymphoblastic leukaemia). We found a significantly high incidence of the GSTM1 null genotype in ALL children (71.7%) compared with 51.7% in the control group of children (P<0.05). The GSTT1 null genotype was observed in 35.0% and 33.3% of the ALL cases and the control subjects respectively, with no significant difference. Screening for NQO1 (609C>T) mutant alleles showed a high incidence of the NQO1 C/C genotype (NQO1 homozygous wild-type allele genotype) in 60.0% of ALL cases and was significantly higher than in the control group (23.3%) (P<0.01). These GSTM1 null and NQO1 wild-type genotypes are independently associated with the risk of ALL in Filipino patients. When these two genotypes, GSTM1 null and NQO1 C/C, were combined, the hazard rate for childhood leukaemia was significantly increased (P<0.001). We also noticed that the incidences of GSTM1 null mutations and the NQO1 C/C genotype were significantly higher among Filipinos. These findings suggest a possible role of the GSTM1 null and NQO1 C/C genotypes in the susceptibility of paediatric ALL cases in the Philippines.

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“…Some studies have reported associations between exposure and risk of ALL; Wen et al [2002] reported an increase risk, albeit not significant, following exposure to laxatives; Alexander et al [2001] reported elevated odds ratios of MLL leukemia following exposure to DNA damaging drugs, dipyrone, and mosquito repellents; and a US case-control study linked childhood leukemia with maternal dietary intake of topisomerase inhibitors [Ross et al, 1996]. Furthermore, a case report described a case of congenital leukemia in the offspring of a mother heavily exposed to premethrin during pregnancy [Borkhardt et al, 2003]. 11q23 MLL rearrangements were identified following cytogenetic analysis of the child's bone marrow and further studies demonstrated the ability of premethrin to induce MLL rearrangements in vitro.…”

Section: Exposuresmentioning

confidence: 96%

Aetiology of childhood leukemia

Lightfoot

2005

Bioelectromagnetics

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Leukemia is the most common cancer to affect children, accounting for approximately a third of all childhood cancers. The major morphological subtypes of leukemia, acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML), are characterized by chromosomal translocations involving over 200 genes including mixed lineage leukemia (MLL), TEL, and AML1. Chromosomal translocations involving the MLL gene at 11q23 are a common feature of infant acute leukemia, found in up to 80% of all cases, and there is strong evidence that rearrangements involving the MLL gene or the TEL-AML1 gene fusion can originate in utero. As with most other cancers, the mechanism by which leukemia arises is likely to involve gene-environment interactions. Accordingly, it is important to identify exposures that cause DNA damage and induce chromosome breaks which are inadequately repaired, ultimately leading to the initiation and disease progression. Exposures acting before birth and early in life has long been thought to be important determinants of leukemia, and the list of suspected chemical, physical, and biological agents continues to increase. Unfortunately, the evidence regarding the majority of suggested exposures is limited and often contradictory, and there are areas, which clearly warrant further investigation in order to further our understanding of the aetiology of childhood leukemia.

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Congenital leukaemia after heavy abuse of permethrin during pregnancy

Cited by 40 publications

References 11 publications

Female Farmworkers’ Perceptions of Pesticide Exposure and Pregnancy Health

Female Farmworkers’ Perceptions of Pesticide Exposure and Pregnancy Health

Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia)

Aetiology of childhood leukemia

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Congenital leukaemia after heavy abuse of permethrin during pregnancy

Cited by 40 publications

References 11 publications

Female Farmworkers’ Perceptions of Pesticide Exposure and Pregnancy Health

Female Farmworkers’ Perceptions of Pesticide Exposure and Pregnancy Health

Prevalence of GSTT1, GSTM1 and NQO1 (609C&gt;T) in Filipino children with ALL (acute lymphoblastic leukaemia)

Aetiology of childhood leukemia

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Product

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Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia)