Congenital infantile fibrosarcoma: review of imaging features

Ainsworth, K; Chavhan, Govind; Gupta, Abha; Hopyan, Sevan; Taylor, Glenn

doi:10.1007/s00247-014-2957-5

Cited by 51 publications

(32 citation statements)

References 25 publications

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“…Rarely, spindle cell rhabdomyosarcoma may arise in an extremity, and it has been described on the thumb in a young child . Histologically, it has a similar composition of whorls of spindle cells, which can be arranged in a herringbone pattern, but its immunohistochemical positivity for desmin and myogenin help to differentiate it from CIFS . Our case was negative for myogenin and desmin.…”

Section: Discussionmentioning

confidence: 68%

“…The high degree of vascularity in these tumors may contribute to misdiagnosis as a vascular lesion by ultrasonographic evaluation, contributing to a delay in diagnosis and treatment . While there are no specific imaging findings to definitively diagnose CIFS or to differentiate it from other soft tissue tumors, MRI can often help to distinguish CIFS from benign vascular lesions, and is essential for defining the extent of the lesion . However, given the hypervascular nature of some CIFS tumors, biopsy is necessary for definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…9,10,16 While there are no specific imaging findings to definitively diagnose CIFS or to differentiate it from other soft tissue tumors, MRI can often help to distinguish CIFS from benign vascular lesions, and is essential for defining the extent of the lesion. 19 However, given the hypervascular nature of some CIFS tumors, biopsy is necessary for definitive diagnosis. Even after tissue biopsy, the diagnosis of these cutaneous masses may be unclear.…”

Section: -11mentioning

confidence: 99%

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Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

et al. 2016

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Congenital infantile fibrosarcoma (CIFS) is a rare neoplasm of infancy that occurs most frequently in the extremities, and when presenting in the skin, may sometimes resemble infantile hemangiomas or other vascular lesions. Clinically, these tumors differ from hemangiomas in the time of onset, morphology, and growth pattern and must be evaluated histologically for definitive diagnosis. We describe an infant with a neoplasm involving the distal left forearm initially presumed to be a vascular lesion after evaluation by two separate ultrasound studies. He presented at seven weeks of life with a multinodular lesion that had enlarged significantly since birth, and the skin biopsy revealed a fibrosarcoma. This case highlights an unusual cutaneous presentation of CIFS, which varies in appearance from the previous 12 cases reported in the literature. We review the clinical manifestations of these congenital masses and emphasize early diagnosis for conservative therapy and improved prognosis.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: -11mentioning

confidence: 99%

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Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

et al. 2016

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“…To our knowledge, there are no previous reports on prenatal CIF originating from the sacrococcygeal region diagnosed by ultrasonography alone. In fact, most reports on the prenatal diagnosis of CIF involve tumors in the limbs and trunk rather than the sacrococcygeal region. Similar to our case, prenatal MRI showed the fibrosarcomas to be isointense to muscle or placenta on T1‐weighted images, and hypo‐ to isointense on T2‐weighted images …”

Section: Discussionmentioning

confidence: 99%

Sonographic features of congenital infantile fibrosarcoma that appeared as a sacrococcygeal teratoma during pregnancy

Suzuki

Murakoshi

Tanaka

et al. 2015

J of Obstet and Gynaecol

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We experienced an extremely rare case of congenital infantile fibrosarcoma originating from the fetal sacrococcygeal region in pregnancy. At first, we suspected fetal sacrococcygeal teratoma; however, the following ultrasonography findings of the tumor complicated this diagnosis: (i) laterality; (ii) no cystic component; (iii) hypervascularity, with the feeding vessels not derived from the middle sacral artery; and (iv) a skin covering. The pathological findings indicated that the tumor was an infantile fibrosarcoma, not a teratoma. Thus, we believe that these sonographic features may aid the prenatal diagnosis of congenital infantile fibrosarcoma, which, in turn, may contribute to a better prognosis and may be useful for parental counseling.

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“…Although ETV6‐NTRK3 is a specific transcript, it is not always observed and diagnosis is sometimes difficult . IFS has nonspecific imaging characteristics, and because of IFS vascularity and presentation, several patients have been misdiagnosed with disorders such as hemangioma or arteriovenous malformation …”

Section: Introductionmentioning

confidence: 99%

Preoperative Treatment With Pazopanib in a Case of Chemotherapy‐Resistant Infantile Fibrosarcoma

Yanagisawa

Noguchi

Fujita

et al. 2015

Pediatric Blood & Cancer

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Clinical and radiological diagnosis of infantile fibrosarcoma (IFS) is challenging because of its similarity to vascular origin tumors. Treatment involves complete resection. Although chemotherapy may allow more conservative resection, treatment guidelines are not strictly defined. One IFS patient with an unresectable tumor had disease progression during chemotherapy. A primary tumor sample showed high VEGFR-1/2/3 and PDGFR-α/β expression. After pazopanib therapy, most tumor showed necrosis within 29 days and could be removed completely, with no relapse in 8 months post-resection. When IFS features hypervascularity, VEGFR and PDGFR expression may be high, thus allowing consideration of VEGFR inhibitors such as pazopanib.

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Congenital infantile fibrosarcoma: review of imaging features

Abstract: Congenital infantile fibrosarcoma has nonspecific imaging characteristics but should be high on the differential diagnosis in a soft-tissue tumor presenting in infancy, located in an extremity and showing tumoral hemorrhage. Patients have a favorable outcome.

Cited by 51 publications

References 25 publications

Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

Sonographic features of congenital infantile fibrosarcoma that appeared as a sacrococcygeal teratoma during pregnancy

Preoperative Treatment With Pazopanib in a Case of Chemotherapy‐Resistant Infantile Fibrosarcoma

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