Congenital Hypothyroidism due to Thyroid Dysgenesis: From Epidemiology to Molecular Mechanisms

Deladoëy, Johnny

doi:10.5772/31019

Cited by 1 publication

(1 citation statement)

References 89 publications

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“…It is recommended that nodules with a diameter <1 cm and without a suspicious history or ultra-sound findings should have a follow-up ultrasound examination and thyroid stimulating hormone (TSH) measurements in 6-18 months [8]. Sonography is the most costeffective means of diagnosing thyroid hemiagenesis [9].…”

Section: Discussionmentioning

confidence: 99%

Hemiagenesis of unilateral lobe of thyroid gland

Karmacharya¹,

Sah²,

Adhikari³

2020

Janaki Med. Coll. J. Med. Sci.

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The thyroid gland begins its development during the 3rd week of gestation from the median endodermal thickening in the floor of the pharynx that later form the median diverticulum. During development, the thyroid gland normally descends to its typical location in front of the pharynx. Failure of descent has been suggested as a cause of thyroid hemiagenesis; however, the compensatory growth of the other lobe suggests a lobulation defect rather than a failure of descent. Abnormalities during the development lead to defective organogenesis or descent, complete or partial absence of the gland with or without ectopic thyroid tissue. Thyroid hemiagenesis is a rare congenital abnormality characterized by the absence or failure to develop one lobe of the thyroid gland with or without the absence of the isthmus. Unilateral thyroid agenesis (thyroid hemiagenesis) is a rare disorder with less than 300 cases currently in the world literature. Here, we report a case of left hemiagenesis of thyroid.

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Section: Discussionmentioning

confidence: 99%