Congenital hypoplasia of the abdominal wall muscles following fetal ascites due to parvovirus B19 infection

Macé, G.; Audry, G.; Cortey, A.; Nguyen, Anh Quoc; Slaïm, L.; Castaigne, Vanina; Garel, Catherine; Carbonne, Bruno

doi:10.1002/uog.8904

Cited by 12 publications

(11 citation statements)

References 15 publications

(10 reference statements)

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“…Additional cases of meconium peritonitis in association with hydrops fetalis in parvovirus B19 infected fetuses were also reported by Schild et al () and Zerbini et al (, ). Congenital hypoplasia of the abdominal muscles in newborns after intrauterine parvovirus B19 infection complicated by hydrops fetalis was also reported (Mace et al, ; Travan et al, ).…”

Section: Introductionmentioning

confidence: 76%

Parvovirus B19 infection during pregnancy and risks to the fetus

Ornoy¹,

Ergaz

2017

Birth Defects Research

106

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Parvovirus B19 infects 1 to 5% of pregnant women, generally with normal pregnancy outcomes. During epidemics, the rate of infection is higher. Major congenital anomalies among offspring of infected mothers are rare, as the virus does not appear to be a significant teratogen. However, parvovirus B19 infection may cause significant fetal damage, and in rare cases, brain anomalies and neurodevelopmental insults, especially if infection occurs in the first 20 weeks of pregnancy. Parvovirus B19 is also an important cause of fetal loss, especially in the second half of pregnancy when spontaneous fetal loss from other causes is relatively rare. Parvovirus B19 infection may affect many fetal organs and can cause severe anemia, following fetal erythroid progenitor cells infection and apoptosis, especially in fetuses, that have shortened half-life of erythrocytes. Severe anemia may cause high output cardiac failure and nonimmune hydrops fetalis. In addition, parvovirus B19 may directly infect myocardial cells and produce myocarditis that further aggravates the cardiac failure. Intrauterine fetal transfusion is commonly used for the treatment of severe fetal anemia with survival rates of 75 to 90% and significant reduction of fetal morbidity. Only 66 cases were evaluated neurodevelopmentally, of which 10 (16%) had slight or severe neurodevelopmental problems. Because parvovirus B19 infection can cause severe fetal morbidity and mortality, it should be part of the routine work-up of pregnant women who have been exposed to the virus or of pregnancies with suspected fetal hydrops. Assessment for maternal infection during pregnancy is especially important during epidemics, when sero-conversion rates are high. Birth Defects Research 109:311-323, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 76%

Parvovirus B19 infection during pregnancy and risks to the fetus

Ornoy¹,

Ergaz

2017

Birth Defects Research

106

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“…It is known that beyond its hematologic effects, parvovirus B19 has a neurological and muscular tropism that may be responsible for unusual presentations in fetal infection, independently of anemia. We cannot rule out the possibility that the virus may directly affect the peritoneal or pleural serosae in some cases of isolated effusions without anemia . Furthermore, Chauvet et al .…”

Section: Discussionmentioning

confidence: 91%

“…We cannot rule out the possibility that the virus may directly affect the peritoneal or pleural serosae in some cases of isolated effusions without anemia. 26 Furthermore, Chauvet et al had already pointed out that isolated pleural effusion should be predictive of non-anemic form. 14 Two cases of maternal mirror syndrome were observed.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops

et al. 2014

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Despite active management by transfusion in fetuses with parvovirus B19 infection, mortality remained substantial during the acute phase of anemia and fetal hydrops. Regression of effusion appears to be an important variable for prognosis. Non-anemic forms exist with isolated refractory ascites or pleural effusion. Maternal mirror syndrome appears to reflect the intensity and persistence of the fetal anemia.

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“…3,7 Other reported ultrasound signs of parvovirus B19 infection include echogenic bowel, meconium peritonitis, first trimester increased nuchal translucency, amniotic fluid abnormalities and myocardial dysfunction. [34][35][36][37][38] 3.4 | Other clinical manifestations of fetal infection…”

Section: Non-invasive Fetal Monitoring With Ultrasoundmentioning

confidence: 99%

Identification and management of congenital parvovirus B19 infection

2020

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Parvovirus B19 (B19V) infection is well known for its mild, self-limiting clinical presentations in children, such as erythema infectiosum. Approximately 40% of women of childbearing age are susceptible to B19V infection. While maternal B19V infection usually has a good prognosis, B19V can cause severe fetal anaemia and pregnancy loss due to its ability to suppress erythroid progenitor cells. Non-invasive ultrasound monitoring for fetal anaemia is usually performed if maternal seroconversion occurs in the first 20 weeks of gestation, with amniocentesis for fetal infection reserved for those who first present with fetal anaemia or hydrops of unknown cause. Intrauterine transfusion is the standard treatment for severe fetal anaemia and is associated with a significant improvement in survival. However, survivors of hydrops fetalis may have a higher rate of long-term neurodevelopmental complications compared with non-hydropic survivors. This review aims to synthesise published data on the diagnosis, surveillance and outcomes of congenital parvovirus infection to assist clinicians in diagnosing and managing this important condition.

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Congenital hypoplasia of the abdominal wall muscles following fetal ascites due to parvovirus B19 infection

Cited by 12 publications

References 15 publications

Parvovirus B19 infection during pregnancy and risks to the fetus

Parvovirus B19 infection during pregnancy and risks to the fetus

Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops

Identification and management of congenital parvovirus B19 infection

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